This month in biomedical research, distilled from PubMed. Updated 2026.10.01.

Study types

Randomized trial / meta-analysis 2 · Human study 2 · Animal (in vivo) 2

Key concepts (papers in this area)

Ischemic Stroke 3 · Oxidative Stress 3 · Neuroinflammatory Diseases 2 · Poststroke Aphasia 1 · Language Function 1 · Systolic Blood Pressure 1

Elsewhere on this page

• Key finding TLNP@Pt/Fe3O4 for Stroke Treatment
• Trial readout Early and prolonged oral edaravone for neuroprotection in acute ischemic stroke: the ERASE-STROKE randomized controlled phase 3 trial.

Representative papers

1. Effectiveness of non-pharmacological therapies for poststroke aphasia: a protocol of a systematic review and network meta-analysis. BMJ open
2. Early and prolonged oral edaravone for neuroprotection in acute ischemic stroke: the ERASE-STROKE randomized controlled phase 3 trial. Science bulletin
3. Metabolic and redox modulation by 2-deoxy-D-glucose and sodium selenite protects against pentylenetetrazole-kindled seizures, neuroinflammation and cognitive dysfunction. Metabolic brain disease
4. Systolic blood pressure targets after successful endovascular thrombectomy: a network meta-analysis of randomized controlled trials. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
5. Effects of electroconvulsive therapy on oxidative stress in schizophrenia. Acta neuropsychiatrica
6. A Brain-Targeted Nanozyme System for Alleviating Poststroke Neuroinflammation via Synergistic Antioxidant and Anti-inflammatory Mechanisms. ACS applied materials & interfaces

Study types

Human study 1 · Animal (in vivo) 2 · In vitro / preclinical 3

Key concepts (papers in this area)

Nanoparticles 3 · Microfluidic Analytical Techniques 2 · Intracellular Delivery 1 · Glycodeoxycholic Acid 1 · Taurocholic Acid 1 · Acoustic Valve Microrobotic System 1

Representative papers

1. A piezoelectric ultrasound-assisted microjetting platform for high-throughput intracellular delivery. Lab on a chip
2. Synthesis and Optimization of PEG-PLGA Immunotherapeutic Nanoparticles for the Controlled Release of IFNα. AAPS PharmSciTech
3. Screening of known gut microbiome-derived metabolites in anti-tumor immunity of colorectal cancer. Journal for immunotherapy of cancer
4. Ultrasound-assisted antifouling for continuous microfluidic manufacturing of RNA-LNP. Lab on a chip
5. Translation, sorting and enrichment: acoustic valve micro robotic system for multifunctional micro manipulation. Lab on a chip
6. Viscoelasticity-dependent, deformation-based sorting of microgels using sequential bifurcations. Lab on a chip

Study types

Randomized trial / meta-analysis 1 · Human study 3 · Animal (in vivo) 1

Key concepts (papers in this area)

Podocytes 3 · Diabetic Nephropathies 2 · Cell-Free Nucleic Acids 1 · Palmitates 1 · Primary Podocytopathy 1 · Rituximab 1

Representative papers

1. Association between anti-rituximab antibodies and treatment efficacy of rituximab in membranous nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
2. Single-Cell RNA Sequencing-Based Identification of Novel Podocyte Injury-Associated Genes From Isolated Glomeruli of Diabetic db/db Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
3. Clinical phenotype and prognosis of patients with diabetic kidney disease complicated by a primary podocytopathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
4. Analysis of urinary kidney-specific cell-free DNA in preeclampsia. PloS one
5. Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post-hoc analysis of the CANVAS and CREDENCE trials. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Study types

Human study 3 · In vitro / preclinical 1

Key concepts (papers in this area)

Deep Learning 2 · Computed Tomography 2 · Convolutional Neural Networks 2 · Image Processing 2 · Lung Diseases 1 · Mandibular Reconstruction 1

Representative papers

1. Interpretable multi-class lung disease classification from chest x-ray images using attention-enhanced deep learning. Biomedical physics & engineering express
2. A Multi-Model, Pixel-Native Framework for Automated Computed Tomography Series Labeling and Characterization: Proof-of-Concept Study. JMIR medical informatics
3. Comparison of multivariate linear regression and random forest model in developing mandibular chin prediction reconstruction equation. Oral and maxillofacial surgery
4. Mitigating the Resolution-Field of View Trade-Off for Comprehensive Microstructural Characterization with Advanced AI Methods. AAPS PharmSciTech

Study types

Human study 2 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Alzheimer Disease 3 · Biomarkers 3 · Hippocampus 1 · Amentoflavone 1 · Bioactive Adrenomedullin 1 · FCGRT 1

Representative papers

1. Impaired peptide amidation and risk of incident dementia in the Malmoe preventive project cohort. Alzheimer's research & therapy
2. A multi-region transcriptomic framework reveals global and region-specific ubiquitin-proteasome system biomarkers in Alzheimer's disease. Functional & integrative genomics
3. A multi-omics and machine-learning framework reveals shared druggable targets for Alzheimer's disease and periodontitis and identifies amentoflavone and taraxerone as potential dual-action natural products. Naunyn-Schmiedeberg's archives of pharmacology
4. Identification of Heme Metabolism-Related Biomarkers in Keloids Using Transcriptomic Analysis and Cultured Human Fibroblasts. Journal of visualized experiments : JoVE

Study types

Randomized trial / meta-analysis 1 · Human study 3

Key concepts (papers in this area)

Progression-Free Survival 3 · Tyrosine Kinase Inhibitors 2 · T-DXd 1 · BCMA-targeted therapies 1 · Ibrutinib 1 · Immune Checkpoint Inhibitors 1

Elsewhere on this page

• Key finding ICIs and TKIs in Cervical Cancer
• Key finding BCMA-Targeted Therapies in Myeloma

Representative papers

1. Uveitis as a class effect of Bruton tyrosine kinase inhibitors: ibrutinib and zanubrutinib ocular toxicity. BMJ case reports
2. Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis. PloS one
3. Efficacy and safety of immune checkpoint inhibitors combined with TKIs for recurrent or metastatic cervical cancer with PIK3CA mutation. PloS one
4. BCMA Targeted Therapies and Their Impact on Outcomes in Relapsed or Refractory Multiple Myeloma: Results From the French EMMY Cohort. European journal of haematology

Study types

Human study 1 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Fibroblasts 3 · Extracellular Matrix 2 · Calotropis 1 · Justicia 1 · HUCMSC-Lipo 1 · ADAMTS2 1

Representative papers

1. Natural multi-target inhibitors from Adhatoda vasica and Calotropis procera for dermal regeneration. Die Naturwissenschaften
2. Inhalable HUCMSC-Lipo biomimetic formulation inhibits fibroblast activation in mouse and non-human primate pulmonary fibrosis models. Science bulletin
3. Integrative Multi-Omics and Machine Learning Reveal Senescent Fibroblast-Associated ADAMTS2 as a Critical Indicator of Intestinal Inflammation in IBD. FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Study types

Human study 1 · In vitro / preclinical 2

Key concepts (papers in this area)

Antifungal Agents 2 · Phenotype 2 · Bacillus subtilis 1 · Bacillus ayatagriensis 1 · Alleles 1 · Aspergillosis, Allergic Bronchopulmonary 1

Representative papers

1. Integrative genomic and phenotypic analyses reveal broad-spectrum antifungal activity and biocontrol potential in Bacillus ayatagriensis. Functional & integrative genomics
2. Targeted allelic diversification of flowering genes via CRISPR-Cas enables the development of multiple early-flowering soybean lines. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
3. Systemic azoles for asthma with fungal sensitisation. The Cochrane database of systematic reviews

Study types

Human study 3

Key concepts (papers in this area)

Large Language Models 2 · misspelling detection 1 · LLAMA3.1-RA 1 · Accuracy 1 · BERT 1 · CharBERT 1

Representative papers

1. Machine Learning to Prioritize High-Severity Patient Safety Events for Institutional Investigation: Algorithm Development and Validation Study. JMIR medical informatics
2. Detecting Misspelled Drug Names Using Transformer-Based Language Models: Model Development and External Validation. JMIR medical informatics
3. Bilingual Performance of Large Language Models in Answering Consumer Health Questions in English and Chinese: Comparative Benchmark Study. Journal of medical Internet research

Study types

Human study 3

Key concepts (papers in this area)

Carcinoma, Non-Small-Cell Lung 2 · Matrix Metalloproteinase 9 1 · Unresectable stage III non-small-cell lung cancer 1 · Compound 1 1 · Compound 2 1 · Compound 5 1

Representative papers

1. In Silico Prioritization of Potential Protein Interactions for Glutathione-Responsive Abasic Site-Trapping Prodrugs in Non-Small Cell Lung Cancer. Journal of visualized experiments : JoVE
2. Single-arm, multicentre phase II trial of sintilimab plus platinum-based doublet chemotherapy followed by adaptive radiotherapy strategy for patients with unresectable stage III non-small-cell lung cancer in China: the ART-LUNG 01 study protocol. BMJ open
3. Real-Time Wristband Monitoring of Hand Hygiene Technique Using Motion Sensors and Machine Learning. Journal of visualized experiments : JoVE

Study types

Human study 1 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Apoptosis 3 · Insulin-Secreting Cells 2 · Gold Nanoparticles 1 · Glucose Homeostasis 1 · miR-3619-5p 1 · MR-409 1

Representative papers

1. GHRH and GLP-1 receptor agonism promote human β-cell survival and improve glucose homeostasis in diabetic mice. Endocrinology
2. Employing Streptomyces enissocaesilis as a sustainable cell factory for green synthesis of gold nanoparticles with multi-target anticancer activity against MCF-7 breast cancer cells. Microbial cell factories
3. Clinical Significance of miR-3619-5p Expression in Patients with Type 2 Diabetes and Its Regulation of Pancreatic β-Cell Proliferation. Journal of visualized experiments : JoVE

Study types

Animal (in vivo) 3

Key concepts (papers in this area)

Ferroptosis 3 · NF-E2-Related Factor 2 3 · GPX4 2 · Ellagic Acid 1 · Metformin 1 · PI3K/Akt/Nrf2 Pathway 1

Elsewhere on this page

• Key finding Pterostilbene in Traumatic Brain Injury

Representative papers

1. Ellagic Acid Enhances RSL3-Induced Ferroptosis by Inhibiting the Nrf2/HO-1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2. Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
3. Pterostilbene Attenuates Neuronal Ferroptosis After Traumatic Brain Injury: Involvement of the SIRT1/PGC-1α/NRF2 Signaling Pathway. Molecular neurobiology

Study types

Human study 3

Key concepts (papers in this area)

Acute Kidney Injury 2 · Fatty Acids, Nonesterified 1 · Report Turnaround Time 1 · Finerenone 1 · Spironolactone 1 · Heart Failure with Mildly Reduced or Preserved Ejection Fraction 1

Representative papers

1. Metabolite-based Analysis of High-Risk Factors on Occurrence of AKI in Patients with Acute Myocardial Infarction. Journal of cardiovascular translational research
2. AI Latency, Report Turnaround Time, and Adoption in a Multi-Vendor AI Ecosystem: A Multi-Site Observational Study. Journal of the American College of Radiology : JACR
3. Finerenone versus spironolactone in heart failure with mildly reduced or preserved ejection fraction: a real-world study. ESC heart failure

Study types

In vitro / preclinical 2

Key concepts (papers in this area)

Algae 1 · Rotating Drum Fermenter 1 · Total Volatile Solids 1 · Anaerobic Plug-Flow Reactor 1 · Biowaste Pasteurization 1 · Glucose 1

Representative papers

1. Near-ideal plug-flow enables stage separation during dry anaerobic digestion of biowaste in a rotating drum fermenter. Waste management (New York, N.Y.)
2. Integrated optimization of ultrasonic pretreatment and substrate mixture for bio-H2 and bio-CH4 production from algal waste: response surface modeling of feedstock characteristics and biogas composition. Waste management (New York, N.Y.)

Study types

Human study 2

Key concepts (papers in this area)

Risk Assessment 2 · Qdenga 1 · Chronic Urticaria 1 · Dengue 1 · Advanced Systemic Treatment 1 · Genetic Risk Score 1

Representative papers

1. Association of a Han Chinese urticaria-derived polygenic risk score with chronic spontaneous urticaria susceptibility and advanced systemic treatment use. The Journal of dermatological treatment
2. Shared evidence, different recommendations: a comparative analysis of Qdenga (TAK-003) dengue vaccine guidance for travellers across countries. Journal of travel medicine

Study types

Human study 2

Key concepts (papers in this area)

Computed Tomography Angiography 2 · Pulmonary Valve 2 · Myxoma 1 · Intimal Sarcoma 1 · Pulmonary Embolism 1 · Surgical Resection 1

Representative papers

1. Cardiac intimal sarcoma presenting with pseudo-pulmonary embolism: surgical debulking, RVOT reconstruction and pulmonary valve replacement. Multimedia manual of cardiothoracic surgery : MMCTS
2. Transverse infundibulotomy for resection of a right ventricular outflow tract myxoma. Multimedia manual of cardiothoracic surgery : MMCTS

Study types

Human study 1 · Animal (in vivo) 1

Key concepts (papers in this area)

Psoriasis 2 · Self-Oscillating Polymeric Network 1 · Copper Nanoparticles 1 · Biological Therapy 1 · Etanercept 1 · Ixekizumab 1

Representative papers

1. Transdermal Transport of a Geometric Self-Oscillating Copper Nanosystem for Topical Treatment of Psoriasis. AAPS PharmSciTech
2. Biologic therapies in pediatric psoriasis: A single-center experience. Archivos argentinos de pediatria

Study types

Human study 2

Key concepts (papers in this area)

Esophagectomy 2 · Esophageal Neoplasms 2 · Delayed Gastric Conduit Emptying 1 · Preoperative Exercise 1 · Geriatric Assessment 1 · Length of Stay 1

Representative papers

1. Applicability and results of the consensus definition of delayed gastric conduit emptying after esophagectomy. Langenbeck's archives of surgery
2. Geriatric co-managed prehabilitation before esophagectomy in patients aged ≥ 65 years with esophageal cancer: a prospective feasibility study with matched historical controls. Langenbeck's archives of surgery

Study types

Human study 2

Key concepts (papers in this area)

Intracranial Aneurysm 2 · Subarachnoid Hemorrhage 2 · Aneurysm, Ruptured 2 · Hospital Mortality 1 · Morphological Changes 1 · Age > 65 Years 1

Representative papers

1. The natural history of untreated small (< 5 mm) intracranial aneurysms: a five-year angiographic follow-up study. Neurosurgical review
2. In-hospital mortality in small (≤ 5 mm) intracranial aneurysms: associations with rupture status, treatment, and complications in a multicenter Latin American cohort. Neurosurgical review

Study types

Human study 2

Key concepts (papers in this area)

Postoperative Complications 2 · Delirium 1 · General Surgery 1 · Melatonin 1 · Gastrectomy 1 · Lymph Node Excision 1

Representative papers

1. Melatonin to improve sleep in patients undergoing major surgery: protocol for a double-blind, randomised placebo-controlled trial (MELROSE). BMJ open
2. Prognostic impact of postoperative complications among elderly patients with gastric cancer. PloS one