This month in biomedical research, distilled from PubMed. Updated 2026.10.02.

Study types

Randomized trial / meta-analysis 3 · Human study 38

Key concepts (papers in this area)

Sarcopenia 10 · Risk Assessment 6 · Age Factors 6 · Frailty 5 · Hypertension 5 · Geriatric Assessment 5

Sub-areas (papers sharing 3+ concepts)

• 7 Muscle Strength · Sarcopenia · Geriatric Assessment
  Muscle strength and HbA1c in geriatric patients with and without diabetes: a retrospective observational cohort study.Identifying biomarkers of accelerated ageing in cancer patients from routine clinical data.
• 5 Triglycerides · Blood Glucose · Triglyceride-glucose index
  Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults.Joint assessment of triglyceride-glucose index and non-traditional lipid parameters for incident stroke risk in middle-aged and older chinese adults: A prospective cohort study based on CHARLS.

Representative papers

1. Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults. Primary care diabetes
2. Sarcopenia Is Associated With Severe Treatment Toxicity and Mortality in Older Adults With Advanced Cancer: A Secondary Analysis. Journal of cachexia, sarcopenia and muscle
3. Joint assessment of triglyceride-glucose index and non-traditional lipid parameters for incident stroke risk in middle-aged and older chinese adults: A prospective cohort study based on CHARLS. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
4. Identifying biomarkers of accelerated ageing in cancer patients from routine clinical data. Mechanisms of ageing and development
5. Sarcopenic Obesity as a Key Determinant of Urinary Incontinence in Older Women. Geriatrics & gerontology international
6. Age-associated patterns of cardiovascular risk and disease phenotypes across diverse care settings: the GLOB-cAGE consortium. American journal of physiology. Heart and circulatory physiology
7. White Blood Cell to HDL-C Ratio and Sarcopenia: A Dual-Cohort Analysis Including Exploratory Insights on Hepatitis B History. Geriatrics & gerontology international
8. A Machine Learning-Derived Risk Scorecard for Pneumonia Hospitalization in Japanese Old-Old Adults. Geriatrics & gerontology international

Study types

Randomized trial / meta-analysis 2 · Clinical trial 4 · Human study 26

Key concepts (papers in this area)

Lung Neoplasms 20 · Carcinoma, Non-Small-Cell Lung 19 · Antineoplastic Combined Chemotherapy Protocols 13 · Immunotherapy 11 · Immune Checkpoint Inhibitors 9 · Drug Therapy 6

Sub-areas (papers sharing 3+ concepts)

• 11 Immunotherapy · Neoplasm Staging · Carcinoma, Non-Small-Cell Lung
  Treatment patterns and outcomes in advanced and metastatic lung cancer in France: Results from the Epidemiological Strategy and medical Economics (ESME) database lung cancer in France.Clinical outcomes of KRAS G12C versus non-G12C mutant NSCLC treated with immunotherapy: a multicentre real-world study.
• 9 Protein Kinase Inhibitors · Antineoplastic Agents · Carcinoma, Non-Small-Cell Lung
  Genomic Profiling, Risk Stratification, and Post-Transformation Treatment Outcomes in Patients with Transformed Small-Cell Lung Cancer: A Multicenter Analysis.The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC).
• 6 Progression-Free Survival · Ovarian Neoplasms · Antineoplastic Combined Chemotherapy Protocols
  Adding immunotherapy to chemotherapy may improve survival after SCLC transformation in EGFR-mutant NSCLC: a multicenter real-world study.Efficacy and safety of immune checkpoint inhibitors combined with TKIs for recurrent or metastatic cervical cancer with PIK3CA mutation.

Elsewhere on this page

• Key finding ICIs and TKIs show high response in cervical cancer
• Trial readout Chemotherapy with or without pembrolizumab followed by maintenance pembrolizumab with or without olaparib as first-line treatment of patients with advanced BRCA non-mutated epithelial ovarian cancer (ENGOT-OV43/GOG-3036/KEYLYNK-001): a randomised, double-blind, placebo-controlled, phase 3 trial.

Representative papers

1. Genomic Profiling, Risk Stratification, and Post-Transformation Treatment Outcomes in Patients with Transformed Small-Cell Lung Cancer: A Multicenter Analysis. Lung cancer (Amsterdam, Netherlands)
2. Adding immunotherapy to chemotherapy may improve survival after SCLC transformation in EGFR-mutant NSCLC: a multicenter real-world study. Lung cancer (Amsterdam, Netherlands)
3. First-line pyrotinib plus apatinib in advanced non-small cell lung cancer harboring HER2 mutations or amplification: a phase II trial. Lung cancer (Amsterdam, Netherlands)
4. Fusion isoform multiplicity and impact on treatment outcomes in ALK-rearranged non-small cell lung cancer with next-generation tyrosine kinase inhibitors. Lung cancer (Amsterdam, Netherlands)
5. Clinical outcomes and genomic features of uncommon EGFR exon 19 deletion subtypes in osimertinib-treated non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands)
6. Analysis of Lymphopenia in Patients with Stage III Non-small Cell Lung Cancer Treated with Chemoradiotherapy and Consolidation Immunotherapy. Clinical oncology (Royal College of Radiologists (Great Britain))
7. Serial ctDNA Analysis for Monitoring Molecular Response and Acquired Resistance in Metastatic NSCLC and HR+/HER2-Negative Breast Cancer: A Real-World Study. Cancer medicine
8. The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC). Lung cancer (Amsterdam, Netherlands)

Study types

Randomized trial / meta-analysis 1 · Human study 25 · Animal (in vivo) 1

Key concepts (papers in this area)

Liver Transplantation 11 · Immunosuppressive Agents 8 · Graft Rejection 8 · Kidney Transplantation 6 · Tacrolimus 5 · Rituximab 5

Sub-areas (papers sharing 3+ concepts)

• 8 Graft Survival · Survival Rate · Liver Transplantation
  Outcomes of a Modified Portal Venovenous Bypass Technique During Liver Transplantation in High-MELD Recipients.Five-Year Outcomes and Clinicopathological Correlations of Kidney Transplants From Deceased Donors With Diabetes.
• 5 Tacrolimus · Immunosuppressive Agents · Mycophenolic Acid
  First Moroccan ABO-Incompatible Living Donor Kidney Transplantation: Successful Desensitization Without Intravenous Immunoglobulin.Differential Oral Absorption Pharmacokinetics of Tacrolimus in Simultaneous Kidney-Pancreas Transplant Compared to Kidney Transplant Recipients.

Representative papers

1. Immunocomplex capture fluorescence analysis for donor selection in HLA-haploidentical peripheral blood stem cell transplantation. Transplant immunology
2. First Moroccan ABO-Incompatible Living Donor Kidney Transplantation: Successful Desensitization Without Intravenous Immunoglobulin. Transplantation proceedings
3. Diagnostic Performance of Donor-derived Cell-free DNA Combined With Immune Activation Markers for Detecting Acute Rejection After Liver Transplantation. Clinical transplantation
4. Intravascular Large B-Cell Lymphoma After Kidney Transplantation: A Rare Form of Post-Transplant Lymphoproliferative Disorder. Transplantation proceedings
5. Outcomes of a Modified Portal Venovenous Bypass Technique During Liver Transplantation in High-MELD Recipients. Clinical transplantation
6. Addition of low-dose antithymocyte globulin to post-transplant cyclophosphamide for effective graft-versus-host disease prophylaxis in peripheral blood stem cell transplantation. Transplant immunology
7. Liver Transplantation for Gestational Alloimmune Liver Disease: Outcomes Analysis From Retrospective Cohort and National Case Series. Pediatric transplantation
8. Impact of ABO incompatibility on adult deceased donor liver transplantation outcomes: A 20-year retrospective study using the SRTR database. Transplant immunology

Study types

Human study 1 · Animal (in vivo) 20

Key concepts (papers in this area)

Hydrogels 17 · Wound Healing 12 · Chitosan 8 · Diabetic Wound Healing 5 · Alginates 5 · Exosomes 3

Sub-areas (papers sharing 3+ concepts)

• 9 Wound Healing · Fibroblasts · Diabetes Mellitus, Experimental
  A living therapeutic material to coordinate metabolic oxygenation and regenerative signaling in diabetic wounds.Hyaluronic acid-based pagoda-shaped hydrogel microneedle loaded with antioxidant nanozyme for machine learning-assisted real-time inflammation monitoring and diabetic wound healing.
• 6 Drug Liberation · Drug Carriers · Chitosan
  pH/ROS dual-responsive injectable hydrogel based on an oxidized hyaluronic acid/carboxymethyl chitosan-phenylboronic acid dynamic network for rheumatoid arthritis therapy.Nanokaolin-reinforced chitosan/poly(vinyl alcohol) hydrogels as transdermal patches with superior anti-swelling, adhesion, and drug release.
• 5 Alginates · Anti-Bacterial Agents · Tannins
  A tea exosome-integrated self-oxygenating cascade chitosan/oxidized alginate hydrogel for remodeling the hyperglycemic and hypoxic microenvironment in diabetic wound healing.Mechanically compliant multifunctional bioadhesive hydrogel for rapid wound repair.

Representative papers

1. A tea exosome-integrated self-oxygenating cascade chitosan/oxidized alginate hydrogel for remodeling the hyperglycemic and hypoxic microenvironment in diabetic wound healing. Carbohydrate polymers
2. Mechanically compliant multifunctional bioadhesive hydrogel for rapid wound repair. Acta biomaterialia
3. pH-Responsive double-network Janus hydrogel incorporates tannic acid-iron nanoparticles for chronic wound healing and monitoring. Acta biomaterialia
4. A living therapeutic material to coordinate metabolic oxygenation and regenerative signaling in diabetic wounds. Acta biomaterialia
5. Regenerative wound healing enabled by recombinant humanized collagen III releasing composite hydrogel. Acta biomaterialia
6. Dual-type dynamic covalent chitosan/whey protein/Sr-doped bioactive glass carriers for hydrophobic compounds: injectable hydrogels and porous scaffolds. Carbohydrate polymers
7. Structurally coupled polysaccharide-lignin tri-domain phyto-cryogel for microenvironment buffering of oxidative and microbial stress in diabetic wounds. Carbohydrate polymers
8. DMBT1 in Adipose-Derived Stem Cell-Derived Exosomes Participates in Alleviating Ferroptosis to Promote Diabetic Wound Healing. Stem cell reviews and reports

Study types

Animal (in vivo) 17 · In vitro / preclinical 1

Key concepts (papers in this area)

Macrophages 8 · STING Protein 4 · cGAS-STING Signaling Pathway 4 · Paclitaxel 2 · Nanostructured Lipid Carriers 1 · Mycobacterium tuberculosis 1

Representative papers

1. An Abraxane-based albumin nanoplatform loaded with a STING agonist for synergistic dual immunotherapy of triple-negative breast cancer. Biomaterials advances
2. 6-Shogaol attenuates liver fibrosis by driving hepatic stellate cell senescence through the cGAS-STING-NF-κB axis. Phytomedicine : international journal of phytotherapy and phytopharmacology
3. Poly(itaconic acid) nanoparticles alleviate inflammation and multiorgan injury in sepsis by promoting nuclear factor erythroid 2-related factor 2 nuclear translocation and macrophage reprogramming. Acta biomaterialia
4. Tyrosine kinase 2 inhibition by GL-V9 treats psoriasiform dermatitis via macrophage-helper T-cell modulation. British journal of pharmacology
5. Talazoparib engages innate immune activation via PARP trapping-dependent cGAS/STING activation in Ewing Sarcoma. Cancer letters
6. Mannose-decorated nanostructured lipid carriers improve the intracellular activity of antitubercular drugs against Mycobacterium tuberculosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
7. Programmable macrophage interface engineering enables targeted antibacterial therapy in immunosuppressed infections. Science bulletin
8. A ROS-responsive coordination nanoplatform integrates antibacterial activity with STING-targeted immunomodulation to attenuate periodontitis. Acta biomaterialia

Study types

Randomized trial / meta-analysis 6 · Clinical trial 1 · Human study 10

Key concepts (papers in this area)

Diabetes Mellitus, Type 2 15 · Hypoglycemic Agents 15 · Hypoglycemia 5 · Semaglutide 5 · Metformin 3 · Sodium-Glucose Transporter 2 Inhibitors 3

Sub-areas (papers sharing 3+ concepts)

• 6 Renal Insufficiency, Chronic · Obesity · Cardiovascular Diseases
  Effects of semaglutide and empagliflozin on markers of endothelial function in persons with type 2 diabetes: A post hoc analysis of a randomized clinical trial.A cross-regional initiative for improving type 2 diabetes mellitus care quality measurement in Spain - The Diabetes Lighthouse project.
• 5 Blood Glucose · Drug Therapy, Combination · Dipeptidyl-Peptidase IV Inhibitors
  Once-weekly IcoSema versus once-daily insulin glargine U100 in type 2 diabetes management (COMBINE 4): an open-label, multicentre, treat-to-target, randomised, phase 3b trial.Durability and Safety of Imeglimin as an Add-On to DPP-4 Inhibitors in Japanese Type 2 Diabetes: The 104-Week FAMILIAR Trial.
• 5 Glucagon-Like Peptide-1 Receptor Agonists · Pioglitazone · Insulin
  Real-world treatment patterns and cost per patient achieving treatment targets among tirzepatide and semaglutide initiators in US patients with type 2 diabetes.Temporal trends and clinical factors associated with hypoglycemia-related hospitalization of patients with type 2 diabetes: a large-scale claims database study in Japan.

Representative papers

1. Effects of semaglutide and empagliflozin on markers of endothelial function in persons with type 2 diabetes: A post hoc analysis of a randomized clinical trial. Journal of diabetes and its complications
2. Fructose-1,6-bisphosphatase deficiency: the clinical characteristics, molecular consequences of FBP1 variants, and emerging non-canonical functions of FBP1. Endocrine journal
3. Effectiveness and Safety of Fixed-Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real-World Study From China. Journal of diabetes
4. A cross-regional initiative for improving type 2 diabetes mellitus care quality measurement in Spain - The Diabetes Lighthouse project. Primary care diabetes
5. Pharmacokinetic and Pharmacodynamic Drug-Drug Interactions Between Cofrogliptin and Metformin in Healthy Subjects: A Single-Center, Single-Arm, Phase I Study in China. Clinical pharmacology in drug development
6. Associations Between Antidiabetic Pharmacotherapy and Hearing Thresholds in Adult Hearing-Impaired Patients With Type 2 Diabetes. Pharmacology research & perspectives
7. Association between SGLT-2 inhibitor use and retinal microvascular parameters in patients with Type 2 diabetes mellitus: A cross-sectional study. Journal of diabetes and its complications
8. Once-weekly IcoSema versus once-daily insulin glargine U100 in type 2 diabetes management (COMBINE 4): an open-label, multicentre, treat-to-target, randomised, phase 3b trial. The lancet. Diabetes & endocrinology

Study types

Randomized trial / meta-analysis 2 · Human study 15

Key concepts (papers in this area)

Diabetes Mellitus, Type 1 15 · Blood Glucose 12 · Continuous Glucose Monitoring 7 · Glycated Hemoglobin 7 · Glycemic Control 6 · Time-in-Range 4

Sub-areas (papers sharing 3+ concepts)

• 7 Insulin · Hypoglycemic Agents · Insulin Infusion Systems
  Real-World Effectiveness and Safety of a Tubeless Automated Insulin Delivery System With an Adaptive Control Algorithm (APGO) in Children and Adolescents With Type 1 Diabetes: A Multicentre Observational Study.Postprandial Glycemic Control With Automated Insulin Delivery With Control-IQ Technology: The Impact of Meal Composition.
• 6 Blood Glucose Self-Monitoring · Blood Glucose · Biomarkers
  Long-term glycemic outcomes at 24 months after switching from FreeStyle Libre to FreeStyle Libre 2: A real-world study.Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta-Cell Function in Migrant-Background Populations.

Representative papers

1. Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta-Cell Function in Migrant-Background Populations. Diabetes, obesity & metabolism
2. Postprandial Glycemic Control With Automated Insulin Delivery With Control-IQ Technology: The Impact of Meal Composition. Diabetes, obesity & metabolism
3. Real-World Effectiveness and Safety of a Tubeless Automated Insulin Delivery System With an Adaptive Control Algorithm (APGO) in Children and Adolescents With Type 1 Diabetes: A Multicentre Observational Study. Diabetes, obesity & metabolism
4. Comparison of Diluted Insulin (U10) Versus Standard (U100) Insulin in Automated Insulin Delivery Systems: Reducing Time Below Range in Young Children. Diabetes, obesity & metabolism
5. Glycemic and safety outcomes of the insulin-only bionic pancreas in older adults and individuals with impaired awareness of Hypoglycemia: a post hoc analysis of a randomized pivotal trial. Diabetes research and clinical practice
6. Long-term glycemic outcomes at 24 months after switching from FreeStyle Libre to FreeStyle Libre 2: A real-world study. Primary care diabetes
7. Experiences With Inhaled Insulin in a Real-World Sample of Adults With Type 1 Diabetes in the T1D Exchange Registry. The science of diabetes self-management and care
8. Beyond Glycaemia: Fear of Hypoglycaemia, Cognition and Functional Mobility After Advanced Hybrid Closed-Loop Therapy in Older Adults With Type 1 Diabetes: A Prespecified Secondary Analysis of a Randomised, Single-Centre Study. Diabetes, obesity & metabolism

Study types

Animal (in vivo) 10 · In vitro / preclinical 6

Key concepts (papers in this area)

Drug Liberation 14 · Drug Delivery Systems 11 · Drug Carriers 9 · Hydrogen-Ion Concentration 7 · Antineoplastic Agents 6 · Fluorouracil 2

Sub-areas (papers sharing 3+ concepts)

• 7 Nanoparticles · Chitosan · Chemistry, Pharmaceutical
  Development of an injectable thermosensitive chitosan-based hydrogel for localized rutin delivery optimized using Box-Behnken design.Formulation and evaluation of sustained-release pitavastatin-loaded chitosan nanoparticles for enhanced anti-hyperlipidemic activity.
• 6 Drug Delivery · Drug Delivery Systems · Drug Carriers
  Gelatin/sodium alginate/zinc oxide hydrogel microspheres for pH-triggered berberine release: A novel dual-functional platform with antitumor and antibacterial properties.Synthesis, characterization, and in vitro evaluation of diglycolamic acid functionalized graphitic carbon nitride for cisplatin delivery.

Representative papers

1. Development of discriminatory and biopredictive bicarbonate buffer-based dissolution method to screen delayed release formulations. Drug development and industrial pharmacy
2. Linoleic acid-based pH-sensitive 5-ASA nanocubosome pellets for colon targeting in ulcerative colitis: in vitro and in vivo comparison with non-pH-sensitive and conventional formulations. Drug development and industrial pharmacy
3. Synthesis, characterization, and in vitro evaluation of diglycolamic acid functionalized graphitic carbon nitride for cisplatin delivery. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
4. Exploring C6N6 as an effective drug delivery carrier for anticancer drugs mercaptopurine and thiotepa: A DFT and MD approach. Computational biology and chemistry
5. Triamcinolone :acetonide-controlled release urinary catheter: Localized delivery with anti-fibrotic and anti-inflammatory effects for preventing urethral stricture. Colloids and surfaces. B, Biointerfaces
6. Electrospun PLA: Gelatin core-shell nanofibers for dual delivery of docetaxel and heparin with enhanced in vitro antiproliferative activity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
7. Tumor microenvironment improved by nanostructured lipid carriers co-delivering paclitaxel and ubenimex to treat breast cancer. Drug development and industrial pharmacy
8. Siligraphene as targeted carrier for 5-FU anticancer drug delivery with smart release: A first-principles study. Computational biology and chemistry

Study types

Randomized trial / meta-analysis 4 · Clinical trial 1 · Human study 11

Key concepts (papers in this area)

Breast Neoplasms 15 · Receptors, Estrogen 8 · Erb-b2 Receptor Tyrosine Kinases 8 · Receptors, Progesterone 5 · Neoplasm Metastasis 4 · HER2-positive breast cancer 2

Sub-areas (papers sharing 3+ concepts)

• 7 Receptors, Estrogen · Biomarkers, Tumor · Breast Neoplasms
  Avutometinib, Abemaciclib, and Fulvestrant in Patients with HR+/HER2- Metastatic Breast Cancer Previously Treated with CDK4/6 Inhibitor: A Single-Arm Phase I Trial.Optimizing the ER Cutoff in HER2-Positive Breast Cancer: ER ≥ 50% Predicts Low pCR Rates and Resistance to Antibody-Drug Conjugates in the Neoadjuvant Setting.
• 5 Overall Survival · Trastuzumab · objective response rate
  Use of Metronomic Chemotherapy in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer: A Retrospective Multicenter Study.Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis.

Elsewhere on this page

• Trial readout Giredestrant plus Everolimus in Advanced Breast Cancer.

Representative papers

1. Optimizing the ER Cutoff in HER2-Positive Breast Cancer: ER ≥ 50% Predicts Low pCR Rates and Resistance to Antibody-Drug Conjugates in the Neoadjuvant Setting. Cancer medicine
2. Trastuzumab deruxtecan rechallenge in HER2-positive metastatic breast cancer: EN-SEMBLE. Breast (Edinburgh, Scotland)
3. Oncotype DX-guided vs physician-directed chemotherapy and survival in HR+/HER2- breast cancer. Breast (Edinburgh, Scotland)
4. Incidence and associated factors of medication-related osteonecrosis of the jaw in breast cancer patients with bone metastases: a nationwide registry study in Finland. Clinical oral investigations
5. Biomarker-based risk stratification for predicting late recurrence and benefit of extended endocrine therapy: A secondary analysis of the IDEAL trial. Breast (Edinburgh, Scotland)
6. Use of Metronomic Chemotherapy in Hormone Receptor-Positive/HER2-Negative Metastatic Breast Cancer: A Retrospective Multicenter Study. Cancer medicine
7. Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis. PloS one
8. The genomic landscape of HER2 negative metastatic breast cancer with loss of estrogen and progesterone receptors. Breast (Edinburgh, Scotland)

Study types

Randomized trial / meta-analysis 3 · Human study 13

Key concepts (papers in this area)

Liver Cirrhosis 8 · Carcinoma, Hepatocellular 7 · Liver Neoplasms 7 · Fatty Liver 6 · Hepatitis B, Chronic 2 · Tenofovir Alafenamide 2

Sub-areas (papers sharing 3+ concepts)

• 6 Fatty Liver · Diabetes Mellitus, Type 2 · Metabolic dysfunction-associated steatotic liver disease
  Major Adverse Liver Outcomes With Tirzepatide and Injectable Semaglutide in Adults With Overweight or Obesity and Type 2 Diabetes.Efficacy of dapagliflozin on hepatic steatosis and fibrosis in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease: a pre-specified single-arm analysis from a randomized controlled trial.

Representative papers

1. High Treatment Adherence Is Associated With Lower Observed HCC Risk in Patients With Chronic Hepatitis B and Cirrhosis: A Nationwide Claims-Based Cohort Study. Journal of medical virology
2. A 7-mm Covered TIPS Reduces Hepatic Encephalopathy Without Increasing Rebleeding in Cirrhotic Patients With Small Liver: A Randomized Study. Liver international : official journal of the International Association for the Study of the Liver
3. Liver transplant allocation by milan criteria may exclude eligible HCC patients without survival benefit - a post-hoc analysis of the SiLVER study. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
4. Impact of PD-1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib-Based Triple Therapy. Liver international : official journal of the International Association for the Study of the Liver
5. Embedding metabolic dysfunction-associated steatotic liver disease fibrosis risk stratification within pharmacist-integrated diabetes comanagement in primary care. Journal of managed care & specialty pharmacy
6. Temporal evolution of tissue-specific insulin resistance and transitions in MASLD status: a retrospective longitudinal cohort study. Diabetes research and clinical practice
7. Predictors of Liver Steatosis Progression Among People Living With HIV in Low- and Middle-Income Countries: A Multicentre Longitudinal Study. Journal of the International AIDS Society
8. Applicability of Non-Invasive Eligibility Criteria for MASH Pharmacotherapy: A Multicentre Cohort Study. Liver international : official journal of the International Association for the Study of the Liver

Study types

Human study 3 · Animal (in vivo) 5 · In vitro / preclinical 6

Key concepts (papers in this area)

Anti-Bacterial Agents 12 · Microbial Sensitivity Tests 11 · Escherichia coli 9 · Staphylococcus aureus 8 · Biofilms 4 · Silver Nanoparticles 3

Sub-areas (papers sharing 3+ concepts)

• 7 Staphylococcus aureus · Anti-Bacterial Agents · Plant Extracts
  Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram-Negative Bacterial Strains.Efficacy Evaluation of Aqueous Extract of Brassica nigra seeds as Antimicrobial Agent against Selected Microorganisms: Gram-Positive Staphylococcus aureus and Gram-Negative Escherichia coli and Pseudomonas aeruginosa.

Elsewhere on this page

• Key finding SHEc enhances drug delivery in pancreatic cancer

Representative papers

1. Phytochemical Composition and Antibacterial Activity of Medicinal Plants Against Bacterial Pathogens Isolated From Livestock Wound Infections. MicrobiologyOpen
2. High and Sustained Release of the Novel Echinocandin Rezafungin From Bone Cement: An In Vitro Comparison With Liposomal Amphotericin B and Micafungin. The Journal of arthroplasty
3. Synthetic mimics of antimicrobial peptides based on poly(diitaconamide): synthesis, bioactivity and stability. Journal of materials chemistry. B
4. Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram-Negative Bacterial Strains. MicrobiologyOpen
5. Novel Peptide-Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking Study. Journal of peptide science : an official publication of the European Peptide Society
6. Hydroxyapatite-Coated Ti6Al4V With Liposome-Encapsulated Gooseberry Extract for Orthopedic Applications. Journal of biomedical materials research. Part A
7. Green Synthesis of Silver Nanoparticles Using the Extract of Adenosma caeruleum R.Br.: Evaluation of Antibacterial, Antifungal and Antioxidant Activity. Applied biochemistry and biotechnology
8. Comparative Analysis of Chemical Composition and Antibacterial Activity of Artemisia argyi and Artemisia lavandulifolia Hydrosols. Chemistry & biodiversity

Study types

Clinical trial 1 · Human study 13

Key concepts (papers in this area)

Anticoagulants 6 · Factor Xa Inhibitors 6 · Apixaban 4 · Direct Oral Anticoagulants 2 · Therapeutic Anticoagulation 1 · Hematoma, Subdural 1

Representative papers

1. Evaluating the Impact of Therapeutic Anticoagulation Management in Head and Neck Free Tissue Transfer: A Retrospective Study of 126 Cases. Microsurgery
2. Direct oral anticoagulant resumption patterns after traumatic subdural hemorrhage in atrial fibrillation: A multicenter cohort study. Clinical neurology and neurosurgery
3. Low-dose rivaroxaban plus antiplatelet therapy for symptomatic intracranial atherosclerotic stenosis: A prospective cohort study. International journal of stroke : official journal of the International Stroke Society
4. Direct oral anticoagulant use and drug-drug interactions in transplant recipients receiving calcineurin inhibitors. Journal of thrombosis and haemostasis : JTH
5. Long-term real-world effectiveness and safety of edoxaban in chronic thromboembolic pulmonary hypertension: a nationwide registry study. Journal of thrombosis and haemostasis : JTH
6. A score system to determine the 5-year survival in patients with asymptomatic carotid stenosis under best medical therapy: Results from the Carotid Asymptomatic Stenosis study. Journal of vascular surgery
7. Citrated Kaolin Reaction Time on Thromboelastography 6s Identifies Bleeding-Prone Phenotypes in Older Adults with Atrial Fibrillation Receiving Direct Oral Anticoagulant Therapy. Cardiovascular drugs and therapy
8. Apixaban Use Before Kidney Transplantation: Is Reversal Necessary? Pharmacotherapy

Study types

Human study 1 · Animal (in vivo) 9 · In vitro / preclinical 4

Key concepts (papers in this area)

Doxorubicin 7 · Cell Proliferation 7 · Reactive Oxygen Species 6 · Colonic Neoplasms 3 · Micelles 2 · Nanobubbles 1

Sub-areas (papers sharing 3+ concepts)

• 6 Reactive Oxygen Species · Particle Size · Cell Survival
  Tyrosine-based melanin-like multifunctional nanocomplexes for combined photothermal/photodynamic therapy of tumors.Dual-responsive self-assembled nanomicelle based on low molecular weight chitosan enhanced the antitumor effect of doxorubicin by disrupting intracellular redox homeostasis.

Representative papers

1. Light-responsive polyphosphoester nanocarriers for cascade-amplified synergistic photodynamic-chemotherapy of colon cancer. Colloids and surfaces. B, Biointerfaces
2. Exosomal lncRNA PVT1 promotes fibroblast activation and colon cancer progression via miR-23b-5p signaling. The Journal of pathology
3. Tyrosine-based melanin-like multifunctional nanocomplexes for combined photothermal/photodynamic therapy of tumors. Colloids and surfaces. B, Biointerfaces
4. pH-sensitive polymer-drug conjugate: An approach to evaluate the effect of the linker on doxorubicin release. Journal of pharmaceutical sciences
5. Mechanism of astragaloside-loaded lactosyl chitosan nanoparticles inhibiting MAPK/ERK pathway and preventing angiogenesis and colon cancer development through miR-200. Pakistan journal of pharmaceutical sciences
6. Bioinspired polydopamine interfacial engineering of plant-derived exosomes enhances doxorubicin bioactivity in 2D and 3D breast cancer models. Biomaterials advances
7. In situgeneration and biological effect evaluation of intracellular nanobubbles. Colloids and surfaces. B, Biointerfaces
8. Restoration of tumor vascular integrity by P188 improves chemotherapy and immunotherapy efficacy in triple negative breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Study types

Human study 13

Key concepts (papers in this area)

Overall Survival 7 · Machine Learning 5 · Predictive Learning Models 4 · Prostate Cancer-Specific Survival 2 · Angiotensin-Converting Enzyme Inhibitors 2 · FLT3 Inhibitors 1

Representative papers

1. Comparison and interpretability of machine learning algorithms to predict survival of patients with prostate cancer. Urologic oncology
2. Prognostic factors of non-metastatic right colon adenocarcinoma: A multicentre retrospective analysis from the ATCCR database. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
3. External validation of the NADIR model for early prostate-specific antigen response prediction in enzalutamide-treated metastatic hormone-sensitive prostate cancer: An analysis of the ARCHES trial. Cancer
4. Secondary fragility fractures after hip fracture surgery in four thousand, four hundred and eighteen older adults: risk factors and internal validation of an interpretable machine-learning model. International orthopaedics
5. Systemic inflammation and prognosis in patients with RAS/BRAF wild-type metastatic colorectal cancer receiving anti-EGFR therapy: A real-world cohort study. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
6. Clinical Outcomes of Metastatic Urothelial Carcinoma Patients Discontinuing Enfortumab Vedotin Due to Toxicity and/or Clinical Response. Clinical genitourinary cancer
7. Impact of FMS-like tyrosine kinase 3 inhibitor maintenance on post-transplant outcomes in acute myeloid leukemia with FMS-like tyrosine kinase 3 mutations: a real-world German registry analysis highlighting sorafenib. Haematologica
8. A Cohort Study on Incidence and Factors Associated With Adverse Drug Reactions of Enalapril in Lusaka, Zambia. Pharmacology research & perspectives

Study types

Human study 13

Key concepts (papers in this area)

Progression-Free Survival 7 · Nivolumab 4 · Carcinoma, Renal Cell 4 · Ipilimumab 3 · Melanoma 3 · CPI2 Model 1

Representative papers

1. A rare case of cytomegalovirus mucositis resembling an immune-related adverse event during treatment with nivolumab and ipilimumab. Auris, nasus, larynx
2. Hemophagocytic lymphohistiocytosis and posterior reversible encephalopathy syndrome during BRAF/MEK inhibitor therapy following immune checkpoint blockade in metastatic melanoma: a case report. Melanoma research
3. Development and external validation of a new prognostic model for metastatic clear cell renal cell carcinoma: a preregistered analysis using data from randomised clinical trials in the checkpoint inhibitor era. The Lancet. Oncology
4. Tumor Mutational Burden Predicts the Outcome of Patients With Muscle-invasive bladder Cancer Undergoing Immune-checkpoint Inhibitor-Based Neoadjuvant Therapy. Clinical genitourinary cancer
5. Impact of post-chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children's Oncology Group AREN0532, AREN0533, and AREN03B2 studies. Cancer
6. Prognostic Impact of Initial Management Strategies in Metachronous Oligometastatic Renal Cell Carcinoma: A Real-World Evidence. Clinical genitourinary cancer
7. Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocytic Leukemia After Limited-Duration Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology
8. Acute development of EBV+ T-cell lymphoproliferative disorder after treatment with rituximab for follicular lymphoma. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Study types

Human study 13

Key concepts (papers in this area)

Alleles 13 · Amino Acid Substitution 13 · Base Sequence 13 · Exons 13 · Histocompatibility Testing 13 · Sequence Alignment 13

Sub-areas (papers sharing 3+ concepts)

• 13 Sequence Analysis, DNA · Sequence Alignment · Histocompatibility Testing
  The Novel HLA-A*02:1128 Was Identified in a Chinese Individual.The Novel HLA-DRB1*04:411 Allele Identified in Eight Unrelated Individuals.

Representative papers

1. Description of the Novel HLA-C*05:01:87 Allele With Single Synonymous Substitution. HLA
2. Identification of the Novel HLA-DRB1*09:01:19 and -DQB1*02:02:38 Alleles and Confirmation of -DPB1*1859:01. HLA
3. Description of Two Novel HLA-A*01 Alleles, HLA-A*01:01:176 and HLA-A*01:520. HLA
4. Discovery of the Novel HLA-C*08:22:06 Allele in a Taiwanese Individual. HLA
5. Characterisation of the Novel HLA-C*04:580 Allele by Sequencing-Based Typing. HLA
6. The Novel HLA-DRB1*04:411 Allele Identified in Eight Unrelated Individuals. HLA
7. Characterisation of the Novel HLA-DQB1*05:377 Allele by Sequencing-Based Typing. HLA
8. Identification of the Novel HLA-C*03:04:119 Allele by Next-Generation Sequencing in a Chinese Cord Blood Donor. HLA

Study types

Human study 13

Key concepts (papers in this area)

Antirheumatic Agents 6 · Antibodies, Monoclonal, Humanized 5 · Propensity Score 4 · Arthritis, Psoriatic 2 · Belimumab 2 · DORIS 1

Representative papers

1. Phenotype-treatment dissociation in psoriatic and nonpsoriatic peripheral spondyloarthritis: a propensity score-matched analysis with novel treatment intensity metrics. Clinical rheumatology
2. Comparative effectiveness and predictors of SRI-4 and LLDAS attainment in active systemic lupus erythematosus: a real-world study of telitacicept versus belimumab. Clinical rheumatology
3. Ruxolitinib for life-threatening corticosteroid-refractory hypereosinophilic syndrome: A multicenter case series. Clinical immunology (Orlando, Fla.)
4. Achievement of real-world adapted DORIS remission targets among patients with systemic lupus erythematosus initiating belimumab in the USA: A retrospective, observational, cohort study. Lupus
5. Incremental Propensity Score Interventions: A Primer for Pharmacoepidemiologists. Pharmacoepidemiology and drug safety
6. Real-world effectiveness of tofacitinib in monotherapy or in combination with csDMARDs in patients with rheumatoid arthritis: A collaboration between Dutch registries (TOFADUDAP study). Clinical rheumatology
7. Risk factors for infection in rheumatoid arthritis patients treated with tocilizumab: an observational study highlighting hydroxychloroquine use. Clinical rheumatology
8. Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients. Journal of immunotherapy (Hagerstown, Md. : 1997)