Collected per day this month
0
500
1,000
1,500
09.01 22 papers
09.02 1,127 papers
09.03 238 papers
09.04 232 papers
09.05 143 papers
09.06 224 papers
09.07 47 papers
09.08 96 papers
09.09 103 papers
09.10 275 papers
09.11 293 papers
09.12 113 papers
09.13 129 papers
09.14 50 papers
09.15 101 papers
09.16 480 papers
09.17 208 papers
09.18 302 papers
09.19 19 papers
09.20 210 papers
09.21 6 papers
09.22 38 papers
09.23 181 papers
09.24 173 papers
09.25 183 papers
09.26 171 papers
09.27 118 papers
09.0109.0609.1109.1609.2109.26
This month by collection topic
Clinical & Disease1,514
Biotech & Drug Development1,201
AI & Genomics1,053
Advanced Therapeutics610
Metabolic & Aging386
Drug Delivery & Formulation304
Targeted Small Molecules214

🧬What Researchers Are Working On

The 17 research areas holding at least 1% of this month's papers each, found by grouping papers that share concepts in the knowledge graph. Together they hold 2,199 of the 5,282 papers (42%); the rest fall in 640 smaller areas.

Track 33-Month Evolution →
  1. 1
    Real-World Outcomes in Hematologic Malignancies354 papers · 6.7%
    Body Mass Index · Hematopoietic Stem Cell Transplantation · Double-Blind Method · Severity of Illness Index

    Study types

    Randomized trial / meta-analysis 43 · Clinical trial 14 · Human study 295 · Animal (in vivo) 1 · In vitro / preclinical 1

    Key concepts (papers in this area)

    Double-Blind Method 28 · Body Mass Index 27 · Severity of Illness Index 26 · Hematopoietic Stem Cell Transplantation 24 · Case-Control Studies 21 · Pilot Projects 18

    Sub-areas (papers sharing 3+ concepts)

    Elsewhere on this page

    • Trial readout Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
    • Trial readout Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

    Representative papers

    1. Feasibility and Efficacy of Lorlatinib in Japanese Patients With Relapsed/Refractory ALK-Aberrant Neuroblastoma. Pediatric blood & cancer
    2. Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia. The New England journal of medicine
    3. The long-term follow-up outcomes and transition rates across seven representative pediatric congenital surgical conditions: disease severity drives follow-up retention. Pediatric surgery international
    4. Iodine status and thyroid function in children with multiple food allergy: a prospective cross-sectional study. Journal of pediatric endocrinology & metabolism : JPEM
    5. Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients. Cancer chemotherapy and pharmacology
    6. Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia. The New England journal of medicine
    7. Hematopoietic Recovery and Safety Following Early Romiplostim Administration After Pediatric HSCT: A Prospective Randomized Pilot Study. Pediatric blood & cancer
    8. Knowledge and practice of evidence-based mild traumatic brain injury guidelines among physicians providing emergency and trauma care in Israel. Israel journal of health policy research
  2. 2
    Survival Outcomes in Lung Carcinoma262 papers · 5.0%
    Overall Survival · Progression-Free Survival · Carcinoma, Non-Small-Cell Lung · Biomarkers, Tumor

    Study types

    Randomized trial / meta-analysis 26 · Clinical trial 25 · Human study 200 · Animal (in vivo) 10 · In vitro / preclinical 1

    Key concepts (papers in this area)

    Overall Survival 91 · Antineoplastic Combined Chemotherapy Protocols 72 · Biomarkers, Tumor 67 · Progression-Free Survival 61 · Lung Neoplasms 54 · Carcinoma, Non-Small-Cell Lung 43

    Sub-areas (papers sharing 3+ concepts)

    Elsewhere on this page

    • Trial readout Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.
    • Trial readout Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

    Representative papers

    1. Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer - results from the phase II DETECT IVb trial. Breast cancer research and treatment
    2. Neoadjuvant Gemcitabine Plus S-1 for Resectable Pancreatic Ductal Adenocarcinoma: A Propensity Score-matched Study. Anticancer research
    3. Therapeutic management of resectable mismatch-repair deficient/microsatellite instability-high gastroesophageal adenocarcinoma: a real-world analysis from Austria. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
    4. Prognostic Value of the Lung Immune Prognostic Index in Metastatic Renal Cell Carcinoma Treated With Second-Line Immunotherapy. International journal of urology : official journal of the Japanese Urological Association
    5. Ovarian reserve as a measure of adjuvant chemotherapy benefit in hormone receptor positive (HR-positive), HER2-negative, node-positive breast cancer in SWOG S1007 (RxPONDER). Annals of oncology : official journal of the European Society for Medical Oncology
    6. Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology
    7. Crossing the milestone: landmark-based conditional survival after first-line CDK4/6 inhibitor therapy in HR+/HER2-metastatic breast cancer. Breast cancer (Tokyo, Japan)
    8. Prognostic Value of Restaging [18F]FDG PET/CT in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [177Lu]Lu-PSMA-617 Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  3. 3
    Machine Learning in Cardiovascular Risk Assessment251 papers · 4.8%
    Machine Learning · Biomarkers · Cardiovascular Diseases · Heart Failure

    Study types

    Randomized trial / meta-analysis 9 · Human study 235 · Animal (in vivo) 3 · In vitro / preclinical 4

    Key concepts (papers in this area)

    Biomarkers 61 · Machine Learning 57 · Risk Assessment 48 · Cardiovascular Diseases 35 · Heart Failure 25 · Mortality 24

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate. Cardiovascular diabetology
    2. Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery. Journal of the American Heart Association
    3. Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. Cardiovascular diabetology
    4. Neighborhood Contemporary Redlining and Racial Mortgage Lending Bias and Cardiovascular Outcomes in Women With Breast Cancer. Journal of the American Heart Association
    5. The Predictive Value of The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score for One-Month Prognosis and First-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation. Brazilian journal of cardiovascular surgery
    6. Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study. JMIR medical informatics
    7. Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. Heart (British Cardiac Society)
    8. Mitochondrial Ferritin in Subclinical Anthracycline-Induced Cardiotoxicity in Humans: A Pilot Study. Journal of cardiovascular translational research
  4. 4
    Anticancer Drug Design and Mechanisms195 papers · 3.7%
    Antineoplastic Agents · Apoptosis · Structure-Activity Relationship · Cell Proliferation

    Study types

    Human study 23 · Animal (in vivo) 100 · In vitro / preclinical 72

    Key concepts (papers in this area)

    Structure-Activity Relationship 130 · Antineoplastic Agents 125 · Molecular Structure 116 · Dose-Response Relationship, Drug 114 · Cell Proliferation 110 · Apoptosis 77

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies. Bioorganic chemistry
    2. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry
    3. Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis. Scientific reports
    4. Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation. Bioorganic chemistry
    5. Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazine derivatives as potent SYK inhibitors for solid tumor therapy. Bioorganic chemistry
    6. A novel c-Met inhibitor containing chiral pyrrolidine side chain and its application as anti-tumor agents. European journal of medicinal chemistry
    7. New N-(isoxazol-3-yl)-4-(1,3,4-thiadiazol-3(2H)-yl)benzenesulfonamide derivatives as potent Aurora kinases inhibitors: Design, synthesis and anti-proliferative activity. Bioorganic chemistry
    8. Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib. European journal of medicinal chemistry
  5. 5
    Nanoparticle Drug Delivery Systems for Wound Healing184 papers · 3.5%
    Hydrogels · Anti-Bacterial Agents · Nanoparticles · Wound Healing

    Study types

    Human study 25 · Animal (in vivo) 103 · In vitro / preclinical 56

    Key concepts (papers in this area)

    Anti-Bacterial Agents 95 · Hydrogels 59 · Nanoparticles 41 · Wound Healing 36 · Escherichia coli 35 · Staphylococcus aureus 34

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Chelate-conjugated β-lactams resensitize metallo-β-lactamase IMP-1-producing gram-negative bacteria against carbapenem antibiotics. Microbiology spectrum
    2. Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices. ACS applied bio materials
    3. Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype. Antimicrobial agents and chemotherapy
    4. Extensively drug-resistant ESBL-producing enterobacterales and coexisting antimicrobial resistance genes are associated with mortality in critically ill patients with cancer. Scientific reports
    5. Phenotypic and molecular detection of efflux pump and expression profiling genes in Klebsiella pneumoniae exposed to ciprofloxacin and amoxicillin/clavulanic acid. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
    6. Essential role of the leucine-293 for the AmpC β-lactamase in the resistance to cefepime, cefiderocol, and new β-lactams/β-lactamase inhibitor combinations in Enterobacter hormaechei. International journal of antimicrobial agents
    7. Antimicrobial activity of aztreonam/avibactam and molecular characterization of Enterobacterales not susceptible to ceftazidime/avibactam and/or meropenem/vaborbactam from US medical centres (2016-2024). The Journal of antimicrobial chemotherapy
    8. Self-Assembling Amphiphilic Cationic Peptide-Based Nanoarchitectures for Soft Biomaterials with Potential Antimicrobial Activity against Clinically Isolated Multidrug-Resistant Bacteria. ACS applied bio materials
  6. 6
    Quality of Life in Cancer Survivors175 papers · 3.3%
    Quality of Life · Neoplasms · Cancer Survivors · Anxiety

    Study types

    Randomized trial / meta-analysis 17 · Clinical trial 1 · Human study 157

    Key concepts (papers in this area)

    Neoplasms 58 · Quality of Life 56 · Cancer Survivors 24 · Anxiety 21 · Palliative Care 18 · Depression 17

    Sub-areas (papers sharing 3+ concepts)

    Elsewhere on this page

    • Trial readout Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.

    Representative papers

    1. Evaluating an innovative support programme for older long-term cancer survivors (IMPULS-A): protocol for a randomised controlled trial. BMJ open
    2. Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer. Psycho-oncology
    3. Effect of active noise-cancelling headphones combined with music therapy on postoperative recovery quality after general anaesthesia for ankle fracture ORIF: a study protocol for a single-centre, four-arm 2×2 factorial randomised controlled trial in China. BMJ open
    4. Exploring the understanding and management of anxiety from cancer in Latino/a older adults and their caregivers. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
    5. Children's participation in assent to paediatric oncology research: experiences of children, siblings and parents. Trials
    6. Spiritual wellbeing in advanced cancer patients receiving palliative care in a tertiary cancer centre in northern Kerala, India: a qualitative study. BMJ open
    7. Psychosocial and supportive care in radiation therapy: a qualitative comparison of Norway and Canada. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
    8. Network analysis of head and neck symptoms and fear of cancer recurrence in postoperative laryngeal cancer patients: simulation-based intervention modeling. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
  7. 7
    Inflammation and Cytokine Signaling96 papers · 1.8%
    Inflammation · NF-kappa B · Cytokines · Signal Transduction

    Study types

    Human study 6 · Animal (in vivo) 81 · In vitro / preclinical 9

    Key concepts (papers in this area)

    Signal Transduction 41 · Inflammation 35 · NF-kappa B 29 · Anti-Inflammatory Agents 24 · Cytokines 23 · TNF-α 19

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis. Fitoterapia
    2. In vivo and molecular docking studies of Micromeria imbricata var. imbricata extract reveal alleviation of the DSS-induced IBD phenotype via interaction with key inflammatory mediators. Journal of ethnopharmacology
    3. Structural elucidation of an active pectin against inflammatory bowel disease from the roots of Sanguisorba officinalis and its protection effect. Carbohydrate polymers
    4. Bioassay-guided discovery of anti-inflammatory sesquiterpenoids from Lindera aggregata (Sims) Kosterm. Bioorganic chemistry
    5. Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α-stimulated ARPE-19 cells. International immunopharmacology
    6. From grey relational-network pharmacology screening to mechanism elucidation: 4-methoxy-2- (3-methylethoxyethane) -phenylisobutyrate from Pimpinella diversifolia essential oil alleviates D-GalN/LPS-induced ALI by targeting the GSK-3β/NF-κB axis. Journal of ethnopharmacology
    7. Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration. Journal of ethnopharmacology
    8. Jiawei Taohe Chengqi decoction improves intestinal barrier damage in sepsis by modulating Notch-mediated macrophage polarization. Cellular immunology
  8. 8
    Ferroptosis and Cancer Therapy92 papers · 1.7%
    Reactive Oxygen Species · Ferroptosis · Photosensitizing Agents · Triple Negative Breast Neoplasms

    Study types

    Randomized trial / meta-analysis 1 · Human study 10 · Animal (in vivo) 69 · In vitro / preclinical 12

    Key concepts (papers in this area)

    Reactive Oxygen Species 47 · Photosensitizing Agents 22 · Ferroptosis 20 · Photochemotherapy 19 · Triple Negative Breast Neoplasms 12 · Immunogenic Cell Death 11

    Sub-areas (papers sharing 3+ concepts)

    Elsewhere on this page

    • Key finding NIR Photocatalyst Induces Immunogenic Cell Death

    Representative papers

    1. Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy. Journal of controlled release : official journal of the Controlled Release Society
    2. Low-Density Lipoprotein-Mimetic Nanoparticles Codelivering Self-Activated Cabazitaxel Prodrug and Verteporfin for Tumor Chemophotodynamic Therapy and Immune Activation. Molecular pharmaceutics
    3. Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation. Journal of hematology & oncology
    4. Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy. Molecular biomedicine
    5. A Minimal Hemin-Albumin Nanozyme with Peroxidase-like Activity Enabling Tyrosine-Crosslinked Hydrogel Formation. ACS applied materials & interfaces
    6. A ClO--responsive porphyrin prodrug for fluorescence imaging and combined chemo-photodynamic treatment of hepatocellular carcinoma cells. Journal of photochemistry and photobiology. B, Biology
    7. Near-Infrared Light Photocatalysis Enables Synergistic Cancer Therapy. Angewandte Chemie (International ed. in English)
    8. Targeted catalytic eradication of antibiotic-resistant Helicobacter pylori by a pH-activated Fe-doped nanozyme. Journal of colloid and interface science
  9. 9
    Biosensing Techniques for Cancer Detection77 papers · 1.5%
    Biosensing Techniques · Limit of Detection · Gold Nanoparticles · Electrochemical Techniques

    Study types

    Human study 32 · Animal (in vivo) 11 · In vitro / preclinical 34

    Key concepts (papers in this area)

    Limit of Detection 53 · Biosensing Techniques 41 · Electrochemical Techniques 26 · Gold 23 · Gold Nanoparticles 15 · Immunoassay 11

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Sustainable Synthesis of N, S-Enriched Carbon Sensor from Euphorbia royleana Latex for Low-Cost Fluorescence Based Detection of Arsenic Ions. Bulletin of environmental contamination and toxicology
    2. Interfacial tripedal DNA walking coupled with oxygen-depletion/ECL-RET dual quenching for femtomolar detection of Tobacco Mosaic Virus RNA in plant extracts. Mikrochimica acta
    3. Aptakiss-guided CRISPR/Cas13a signal amplification for ultrasensitive FEN1 detection using CsPbBr3@PDA@AuNPs-based electrochemiluminescence platform. Biosensors & bioelectronics
    4. A Dual-Mode Fluorescent and Colorimetric Biosensor Based on AuNPs@RCA Nanogel-Integrated Multipedal DNA Walker for Ultrasensitive miRNA Detection. ACS applied materials & interfaces
    5. A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles. Analytica chimica acta
    6. A novel fluorescent sensor based on CdTe quantum dots and DTAB-modified Au nanoparticles through aggregation-induced fluorescence recovery for the detection of l-lysine. Journal of the science of food and agriculture
    7. Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage. Analytica chimica acta
    8. A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone. Mikrochimica acta
  10. 10
    Pharmaceutical Formulation and Drug Delivery75 papers · 1.4%
    Chemistry, Pharmaceutical · Solubility · Drug Liberation · Drug Compounding

    Study types

    Human study 7 · Animal (in vivo) 16 · In vitro / preclinical 52

    Key concepts (papers in this area)

    Chemistry, Pharmaceutical 47 · Solubility 32 · Drug Compounding 29 · Drug Liberation 27 · Bulk Drugs 26 · Tablets 23

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Ultrasonic evaluation of permanent moisture impact on microstructural and micro-viscoelastic properties of pharmaceutical tablets: a proof of concept study. International journal of pharmaceutics
    2. Real-Time Monitoring of Tablet API Concentration and Bioavailability via Dissolution Kinetics in Simulated Stomach Fluid by T-Ray Transmission Technique. AAPS PharmSciTech
    3. Impact of mixing method on amorphous solid dispersions fabricated via vacuum compression molding: dissolution and degree of fusion. International journal of pharmaceutics
    4. Novel Hybrid Polymer-Lipid-Based Formulations for Enhanced Dissolution Rates of Poorly Water-Soluble Drugs: A Quality by Design (QbD) Approach via Hot Melt Extrusion. AAPS PharmSciTech
    5. Low-temperature FDM 3D printing of immediate-release glipizide tablets: formulation optimization, solid-state characterization, and dose customization. International journal of pharmaceutics
    6. Scalable generation of droplet-templated amorphous solid dispersions using continuous antisolvent extraction. International journal of pharmaceutics
    7. A structure dosage form approach for solubility and dissolution rate enhancement. International journal of pharmaceutics
    8. Dissolution Enhancement by Binding Agents: A Potential Shortcut to Improving Bioavailability? The AAPS journal
  11. 11
    Postoperative Outcomes in Robotic Surgery71 papers · 1.3%
    Postoperative Complications · Robotic Surgical Procedures · Length of Stay · Robot-Assisted Radical Prostatectomy

    Study types

    Randomized trial / meta-analysis 6 · Clinical trial 1 · Human study 64

    Key concepts (papers in this area)

    Robotic Surgical Procedures 30 · Postoperative Complications 26 · Length of Stay 17 · Operative Time 10 · Robot-Assisted Radical Prostatectomy 7 · Gastrectomy 6

    Sub-areas (papers sharing 3+ concepts)

    Elsewhere on this page

    • Trial readout A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.

    Representative papers

    1. Are we missing an important point? Risk factors for intraoperative complications and additional procedures when performing post-chemotherapy RPLND for testicular tumors. Japanese journal of clinical oncology
    2. Clinical performance of da Vinci 5 versus Xi for robotic anatomic lung resection: a propensity-weighted analysis. Journal of robotic surgery
    3. Side-specific lower detrusor apron-sparing robot-assisted radical prostatectomy: functional and oncological outcomes. World journal of urology
    4. Preservation of the superior fascia of the pelvic diaphragm is associated with greater continence recovery after non-nerve-sparing robot-assisted radical prostatectomy. Journal of robotic surgery
    5. Total periurethral anatomical preservation during single-port extraperitoneal robot-assisted radical prostatectomy using a modified hood technique. Journal of robotic surgery
    6. Perioperative safety and survival outcomes of robot-assisted partial nephrectomy in elderly patients with localized renal cell carcinoma: an overlap-weighted Asian cohort study. Journal of robotic surgery
    7. Single-port robotic prostatectomy is associated with higher same-day discharge and reduced length of stay: a NSQIP analysis. World journal of urology
    8. Robot‑assisted thoracoscopic surgery for pediatric mediastinal tumors: a 5‑year experience with 168 cases. Journal of robotic surgery
  12. 12
    Drug Resistance in Breast and Ovarian Cancer65 papers · 1.2%
    Breast Neoplasms · Doxorubicin · Drug Resistance, Neoplasm · MCF-7 Cells

    Study types

    Human study 4 · Animal (in vivo) 39 · In vitro / preclinical 22

    Key concepts (papers in this area)

    Drug Resistance, Neoplasm 26 · Breast Neoplasms 22 · Doxorubicin 13 · MCF-7 Cells 13 · Ovarian Neoplasms 10 · Cisplatin 8

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Birinapant enhances cisplatin sensitivity in epithelial ovarian cancer through modulation of apoptotic and survival signaling pathways. Cancer chemotherapy and pharmacology
    2. The Phosphatidylinositol 3-Kinase (PI3K) Inhibitor Inavolisib Has Breast-cancer Synergy Combined With Recombinant Methioninase But Not on Normal Cells. In vivo (Athens, Greece)
    3. CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas. Cancer chemotherapy and pharmacology
    4. Expanding the scope of platinum-NHC complexes: trans-Pt(II) and Pt(0) architectures for ovarian cancer treatment. Dalton transactions (Cambridge, England : 2003)
    5. Synergy of KRAS-inhibitor Daraxonrasib Combined With Recombinant Methioninase on Pancreatic-cancer Cells But Not Normal Cells. Anticancer research
    6. A Platinum(IV) Metallo-Stapling Approach to Tumor-Specific Prodrugs for Targeted Chemo-Immunometabolic Cancer Therapy. Angewandte Chemie (International ed. in English)
    7. Synthesis and cytotoxicity evaluation of steroidal 17β-hydroxy-17α-methylisoxazoles. Steroids
    8. Targeting ALDH2 with Alda-1 to reverse cisplatin resistance in lung adenocarcinoma. Cancer chemotherapy and pharmacology
  13. 13
    Anticoagulation in Stroke and Atrial Fibrillation65 papers · 1.2%
    Ischemic Stroke · Stroke · Atrial Fibrillation · Acute Kidney Injury

    Study types

    Randomized trial / meta-analysis 12 · Human study 52 · Animal (in vivo) 1

    Key concepts (papers in this area)

    Ischemic Stroke 18 · Stroke 18 · Atrial Fibrillation 13 · Acute Kidney Injury 8 · Direct Oral Anticoagulants 7 · Aspirin 7

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial. BMJ open
    2. Reduced-dose direct oral anticoagulant versus antiplatelet strategies after left atrial appendage occlusion. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
    3. Etiologic spectrum of direct oral anticoagulant breakthrough stroke in atrial fibrillation: The role of pseudo-failure and non-cardioembolic mechanisms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    4. Effect of periprocedural antithrombotic medication on functional outcome and symptomatic intracranial hemorrhage in patients with carotid tandem lesions. BMJ open
    5. A biomimetic nano-platelet as an antidote for dual antiplatelet therapy-induced bleeding. Journal of controlled release : official journal of the Controlled Release Society
    6. Early-event pathways to 6-month death or dependency after ischemic stroke: Secondary analysis of the international stroke trial. Journal of the neurological sciences
    7. API-CAT investigators' decisions on anticoagulation following extended treatment for cancer-associated thrombosis. European heart journal. Cardiovascular pharmacotherapy
    8. Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. European heart journal
  14. 14
    Neurodegeneration and Cognitive Dysfunction64 papers · 1.2%
    Alzheimer Disease · Hippocampus · Cognitive Dysfunction · Amyloid beta-Peptides

    Study types

    Randomized trial / meta-analysis 1 · Human study 10 · Animal (in vivo) 52 · In vitro / preclinical 1

    Key concepts (papers in this area)

    Alzheimer Disease 24 · Hippocampus 23 · Amyloid beta-Peptides 14 · Cognitive Dysfunction 13 · Microglia 13 · Proteomics 9

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Triangulating the Neuroprotective Mechanisms of Pterostilbene in Hyperhomocysteinemia Induced Cognitive Impairment: Insights from In Silico, Proteomics, and Experimental Validation. Neuromolecular medicine
    2. High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence. Experimental brain research
    3. SVHRSP Attenuates PTZ-Induced Seizure-Like Behavior in C. elegans: Involvement of HSF-1 and Associated Changes in GABAergic Markers and Mitochondrial Homeostasis. Neurochemical research
    4. Neuroprotective and cognitive-enhancing effects of γ-Oryzanol in bile duct ligation-induced hepatic encephalopathy in rats. Metabolic brain disease
    5. Effects of Intravenously Administered Plasma from Exercise-Trained Donors on Mitochondrial Respiration in a Rat Model of Alzheimer's Disease. Medicine and science in sports and exercise
    6. Nose-to-brain delivery of empagliflozin-loaded nanostructured lipid carriers incorporated in-situ gel: Biopharmaceutical evaluation for Alzheimer's disease. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
    7. Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. Journal of ethnopharmacology
    8. Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation. Molecular biology reports
  15. 15
    Immunotherapy and Tumor Microenvironment60 papers · 1.1%
    Macrophages · CD8-Positive T-Lymphocytes · CD8+ T cells · Dendritic Cells

    Study types

    Clinical trial 2 · Human study 3 · Animal (in vivo) 53 · In vitro / preclinical 2

    Key concepts (papers in this area)

    Macrophages 28 · CD8+ T cells 12 · Dendritic Cells 9 · CD8-Positive T-Lymphocytes 8 · T-Lymphocytes, Regulatory 7 · Tumor-Associated Macrophages 5

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Carnosic acid and carnosol promote lipid mediator class-switching toward inflammation resolution in human macrophages. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
    2. Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling. Lung
    3. Messenger RNA delivery of a dual CD25/CD122 affinity-tuned IL-2 variant prolongs exposure and potentiates antitumor T cell immunity. Science advances
    4. Zhimu-Huangbo herb pair ameliorates diabetic cognitive impairment by modulating the CCL3-CCR5 axis-dependent interaction between neurons and CD8+ T cells. Phytomedicine : international journal of phytotherapy and phytopharmacology
    5. AMnESTI reverses age-associated lung immune decline to drive heterosubtypic protection by inactivated influenza vaccines. Science immunology
    6. The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases. Virulence
    7. Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells. Proceedings of the National Academy of Sciences of the United States of America
    8. Colitis Ameliorates Murine Autoimmune Cholangitis Through Polarization of M2 Macrophages and Inhibition of CD8+ T-Cells. In vivo (Athens, Greece)
  16. 16
    Lupus Nephritis and Immunotherapy60 papers · 1.1%
    Lupus Nephritis · Rituximab · Lupus Erythematosus, Systemic · Glucocorticoids

    Study types

    Randomized trial / meta-analysis 2 · Clinical trial 3 · Human study 54 · Animal (in vivo) 1

    Key concepts (papers in this area)

    Rituximab 11 · Lupus Erythematosus, Systemic 10 · Glucocorticoids 9 · Lupus Nephritis 8 · Lymphoma, Large B-Cell, Diffuse 6 · Lymphoma, Follicular 6

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Clinical and immunological outcomes of rituximab-based, mycophenolate mofetil-based and cyclophosphamide-based treatment strategies for systemic lupus erythematosus with active kidney involvement from LOOPS registry. RMD open
    2. Clinical Predictors of Non-Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic-Range Proteinuria. Nephrology (Carlton, Vic.)
    3. Patterns of care, outcomes, and prognostics for transformed follicular lymphoma in the rituximab era. Haematologica
    4. Evaluating a guideline-aligned prednisone threshold within the Lupus Low Disease Activity State (LLDAS): associations with damage accrual. RMD open
    5. Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan. Lupus science & medicine
    6. CD19 CAR T-cell therapy (GLPG5101) for relapsed or refractory B-cell non-Hodgkin lymphoma (ATALANTA-1): phase 1 results from a single-arm, multicentre, phase 1/2 study. The Lancet. Haematology
    7. Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease. Annals of medicine
    8. Discomfort Avoidance and Desire for Normality Are Decision-Making Drivers of Footwear Choice in Underserved Communities at Risk of Diabetic Foot Ulcer. Journal of foot and ankle research
  17. 17
    Stem Cells and Bone Regeneration53 papers · 1.0%
    Mesenchymal Stem Cells · Exosomes · Osteogenesis · Bone Regeneration

    Study types

    Animal (in vivo) 43 · In vitro / preclinical 10

    Key concepts (papers in this area)

    Mesenchymal Stem Cells 24 · Exosomes 18 · Osteogenesis 13 · Cell Differentiation 11 · Bone Regeneration 6 · Glycolysis 3

    Sub-areas (papers sharing 3+ concepts)

    Representative papers

    1. Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications. Journal of dentistry
    2. Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study. BMC oral health
    3. Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
    4. Mesenchymal Stem Cell-Derived Exosomes Combined With 3-Dimensional Hyaluronan-Based Scaffold Promote Tendon-to-Bone Tunnel Healing. The Journal of hand surgery
    5. Chitosan nanoparticles promote TGF-Β1 release from dentin and support stem cell attachment and differentiation in vitro. Journal of dentistry
    6. Leek-Derived Exosome-like Nanoparticles Inhibit Hair Growth by Controlling the Differentiation Fate of Hair Follicle Stem Cells. ACS applied bio materials
    7. Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone defects. Cell stem cell
    8. Gelatin Methacrylate as a Mesenchymal Stem Cell Delivery Vehicle: Experimental and Semi-Quantitative Evaluation Under Metabolic Stress. Macromolecular bioscience

Real-World Outcomes in Hematologic Malignancies

354 papers · 6.7% of the month

Study types

Randomized trial / meta-analysis 43 · Clinical trial 14 · Human study 295 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Double-Blind Method 28 · Body Mass Index 27 · Severity of Illness Index 26 · Hematopoietic Stem Cell Transplantation 24 · Case-Control Studies 21 · Pilot Projects 18

Sub-areas (papers sharing 3+ concepts)

Elsewhere on this page

  • Trial readout Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
  • Trial readout Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

Representative papers

  1. Feasibility and Efficacy of Lorlatinib in Japanese Patients With Relapsed/Refractory ALK-Aberrant Neuroblastoma. Pediatric blood & cancer
  2. Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia. The New England journal of medicine
  3. The long-term follow-up outcomes and transition rates across seven representative pediatric congenital surgical conditions: disease severity drives follow-up retention. Pediatric surgery international
  4. Iodine status and thyroid function in children with multiple food allergy: a prospective cross-sectional study. Journal of pediatric endocrinology & metabolism : JPEM
  5. Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients. Cancer chemotherapy and pharmacology
  6. Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia. The New England journal of medicine
  7. Hematopoietic Recovery and Safety Following Early Romiplostim Administration After Pediatric HSCT: A Prospective Randomized Pilot Study. Pediatric blood & cancer
  8. Knowledge and practice of evidence-based mild traumatic brain injury guidelines among physicians providing emergency and trauma care in Israel. Israel journal of health policy research