This month in biomedical research, distilled from PubMed. Updated 2026.09.29.

Study types

Randomized trial / meta-analysis 47 · Clinical trial 22 · Human study 416 · Animal (in vivo) 1 · In vitro / preclinical 2

Key concepts (papers in this area)

Antineoplastic Combined Chemotherapy Protocols 69 · Neoplasm Staging 49 · Disease-Free Survival 37 · Neoplasm Recurrence, Local 37 · Neoadjuvant Therapy 32 · Hematopoietic Stem Cell Transplantation 24

Sub-areas (papers sharing 3+ concepts)

• 48 Breast Neoplasms · Neoadjuvant Therapy · Pathologic Complete Response
  Efficacy of adjuvant chemotherapy for triple-negative early breast cancer with tumor size ≤ 1 cm and node-negative from the National Clinical Database-Breast Cancer Registry in Japan.Chemotherapy type and survival in young BRCA1/2 carriers with HER2-negative early breast cancer.
• 41 Gastrectomy · Neoplasm Staging · Colorectal Neoplasms
  Adjuvant oxaliplatin with S-1 (SOX) versus S-1 for stage II-III gastric cancer (CAPITAL): A randomized, open-label, phase 3 trial.Preoperative RDW-Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery.
• 37 Progression-Free Survival · Antineoplastic Combined Chemotherapy Protocols · Leucovorin
  The addition of bevacizumab to combination chemotherapy in patients with recurrent, persistent, or metastatic cervical cancer: Aretrospective single-arm study.Real-world safety and effectiveness of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: A multicenter Japanese cohort study.
• 24 Prostatic Neoplasms · Prostatectomy · Prostate-Specific Antigen
  Oncological and perioperative outcomes following salvage robotic radical prostatectomy after radiation versus focal therapy: a multicenter analysis of 441 patients.Early functional and oncological outcomes after robot-assisted radical prostatectomy in D'Amico high-risk prostate cancer: a prospective cohort study.
• 23 Venetoclax · Bridged Bicyclo Compounds, Heterocyclic · Measurable Residual Disease
  Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia.Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients.
• 22 Carcinoma, Hepatocellular · Liver Neoplasms · Brain Neoplasms
  Weight loss despite nutritional support predicts poor outcomes after postoperative chemoradiotherapy for high-risk head and neck cancer.Association of AI-derived abdominal organ volumetry with postoperative outcomes in clear cell renal cell carcinoma: a multicentre study.

Elsewhere on this page

• Trial readout Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
• Trial readout Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
• Trial readout Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

Representative papers

1. Contemporary therapy for small node-negative triple-negative breast cancer: a retrospective cohort study. Breast cancer research and treatment
2. Oncological and perioperative outcomes following salvage robotic radical prostatectomy after radiation versus focal therapy: a multicenter analysis of 441 patients. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
3. Effect of demographic characteristics on the outcome of prostate cancer salvage radiotherapy: Analysis from a randomized controlled trial. Cancer
4. Preservation of the superior fascia of the pelvic diaphragm is associated with greater continence recovery after non-nerve-sparing robot-assisted radical prostatectomy. Journal of robotic surgery
5. Neoadjuvant Gemcitabine Plus S-1 for Resectable Pancreatic Ductal Adenocarcinoma: A Propensity Score-matched Study. Anticancer research
6. Ovarian reserve as a measure of adjuvant chemotherapy benefit in hormone receptor positive (HR-positive), HER2-negative, node-positive breast cancer in SWOG S1007 (RxPONDER). Annals of oncology : official journal of the European Society for Medical Oncology
7. Early functional and oncological outcomes after robot-assisted radical prostatectomy in D'Amico high-risk prostate cancer: a prospective cohort study. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
8. Teclistamab-associated adverse events: a disproportionality analysis of the FDA adverse event reporting system. Hematology (Amsterdam, Netherlands)

Study types

Human study 20 · Animal (in vivo) 137 · In vitro / preclinical 70

Key concepts (papers in this area)

Antineoplastic Agents 140 · Structure-Activity Relationship 138 · Molecular Structure 119 · Dose-Response Relationship, Drug 113 · Cell Proliferation 110 · Drug Screening Assays, Antitumor 94

Sub-areas (papers sharing 3+ concepts)

• 83 Cell Proliferation · Drug Screening Assays, Antitumor · Structure-Activity Relationship
  Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.
• 54 Reactive Oxygen Species · Photosensitizing Agents · Photochemotherapy
  Piperazine and Morpholine Protoporphyrin IX Derivatives Intensify Biomolecules Oxidation and Phototoxicity in Triple-Negative Breast Cancer.Harnessing light and ultrasonic vibration: efficient amphiphilic phthalocyanine-based sensitizers for combined sono-photodynamic therapy of breast cancer.
• 47 Molecular Dynamics Simulation · Structure-Activity Relationship · Dose-Response Relationship, Drug
  Discovery of new thiazolyl hydrazone derivatives as anti-breast cancer agents: Synthesis, biological evaluation and in silico studies.Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation.
• 37 Molecular Docking Simulation · Protein Kinase Inhibitors · ErbB Receptors
  Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies.New N-(isoxazol-3-yl)-4-(1,3,4-thiadiazol-3(2H)-yl)benzenesulfonamide derivatives as potent Aurora kinases inhibitors: Design, synthesis and anti-proliferative activity.

Elsewhere on this page

• Key finding SNAP-TAC Enables Tumor-Selective Therapy

Representative papers

1. Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies. Bioorganic chemistry
2. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry
3. Dual-masked cathepsin B-activated 5-aminolevulinic acid prodrugs with enhanced photodynamic cytotoxicity. Bioorganic chemistry
4. Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib. European journal of medicinal chemistry
5. Structural optimization of benzophenanthridinone and benzophenanthridine Tyrosyl-DNA phosphodiesterase 1 inhibitors and their radiosensitizing activity. European journal of medicinal chemistry
6. Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis. Scientific reports
7. Design, synthesis, and biological evaluation of novel selenium-matrine hybrid compounds as topo I -targeted anticancer agents. Bioorganic chemistry
8. Terephthaloyl-based amide-linked derivatives and polymeric networks with selective cytotoxicity: In vitro evaluation, Molecular docking, Molecular dynamics, and DFT insights. Bioorganic chemistry

Study types

Randomized trial / meta-analysis 1 · Human study 20 · Animal (in vivo) 126 · In vitro / preclinical 78

Key concepts (papers in this area)

Drug Liberation 73 · Drug Delivery Systems 69 · Nanoparticles 60 · Drug Carriers 59 · Particle Size 56 · Hydrogels 51

Sub-areas (papers sharing 3+ concepts)

• 53 Drug Carriers · Drug Liberation · Drug Delivery Systems
  Syringic Acid-Loaded Emulsomes as a Neuroprotective Delivery System: Formulation Optimization and In-Vivo Pharmacokinetic Evaluation.pH-Responsive Chitosan-Coated Spanlastic Nanovesicles for Enhanced Lung-Targeted Delivery of Brilliant Blue G in Acute Lung Injury.
• 42 Chemistry, Pharmaceutical · Bulk Drugs · Solubility
  Novel Hybrid Polymer-Lipid-Based Formulations for Enhanced Dissolution Rates of Poorly Water-Soluble Drugs: A Quality by Design (QbD) Approach via Hot Melt Extrusion.A structure dosage form approach for solubility and dissolution rate enhancement.
• 40 Nanoparticles · Liposomes · Antineoplastic Agents
  Formulation, Optimization and Characterization of Acetazolamide-Loaded Solid Lipid Nanoparticles for Glaucoma Treatment: In-Vitro and In-Vivo Study.Dual-drug-loaded lipid-based formulation for colon cancer therapeutics: in vitro optimization and characterization.
• 33 Skin · Administration, Cutaneous · Skin Absorption
  Topical PEGylated azelaic acid nanohybrids: A lipid-polymer hydrogel system for sustained dermal delivery in rosacea management.Clobetasol-loaded core-active lipid nanoparticles: an enhanced therapy for inflammatory skin conditions.
• 25 Hydrogels · Wound Healing · Anti-Bacterial Agents
  An injectable thermosensitive HTCC/Pluronic F127 hydrogel with sustained EGF release for accelerated diabetic wound healing.A Dual-Crosslinked Collagen/Hyaluronic Acid/Chitosan Hydrogel for Integrated Hemostasis and Infected Wound Healing.
• 5 Gelatin Methacryloyl · Gelatin · Biocompatible Materials
  Mechanistic understanding of LAI suspension intramuscular depot formation: A physicochemical perspective.Fabrication of bilayer nerve conduits with sustained drug release using a multi-material, embedded 3D printing strategy.

Elsewhere on this page

• Key finding Intranasal SLNs Reduce Glioblastoma Volume

Representative papers

1. Novel Hybrid Polymer-Lipid-Based Formulations for Enhanced Dissolution Rates of Poorly Water-Soluble Drugs: A Quality by Design (QbD) Approach via Hot Melt Extrusion. AAPS PharmSciTech
2. Evaluation of the physical and radiological properties of different Fricke gel formulations as water-equivalent materials and biological tissues. Biomedical physics & engineering express
3. Impact of mixing method on amorphous solid dispersions fabricated via vacuum compression molding: dissolution and degree of fusion. International journal of pharmaceutics
4. Single-Step Solvent Evaporation Via Spray-Drying for the Production of Ph-Sensitive Polymeric Nanospheres for Dermatological Applications. AAPS PharmSciTech
5. Real-Time Monitoring of Tablet API Concentration and Bioavailability via Dissolution Kinetics in Simulated Stomach Fluid by T-Ray Transmission Technique. AAPS PharmSciTech
6. Low-temperature FDM 3D printing of immediate-release glipizide tablets: formulation optimization, solid-state characterization, and dose customization. International journal of pharmaceutics
7. Scalable generation of droplet-templated amorphous solid dispersions using continuous antisolvent extraction. International journal of pharmaceutics
8. A structure dosage form approach for solubility and dissolution rate enhancement. International journal of pharmaceutics

Study types

Randomized trial / meta-analysis 25 · Clinical trial 1 · Human study 168 · Animal (in vivo) 4 · In vitro / preclinical 4

Key concepts (papers in this area)

Diabetes Mellitus, Type 2 78 · Obesity 55 · Body Mass Index 49 · Blood Glucose 49 · Diabetes Mellitus, Type 1 35 · Glycated Hemoglobin 33

Sub-areas (papers sharing 3+ concepts)

• 62 Obesity · Body Mass Index · Overweight
  Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis.
• 52 Diabetes Mellitus, Type 2 · Glycated Hemoglobin · Diabetes Mellitus
  Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT.Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality.
• 30 Hypoglycemic Agents · Glucagon-Like Peptide-1 Receptor Agonists · Dipeptidyl-Peptidase IV Inhibitors
  Effects of Pharmacological GIP Infusion on Insulin, Glucagon, and Cardiovascular Responses During Hyperglycemia in Type 2 Diabetes.Changes in recorded background glucose-lowering therapy after initiation of a GLP-1 receptor agonist or dual GIP/GLP-1 receptor agonist in adults with type 2 diabetes.
• 26 Insulin Infusion Systems · Diabetes Mellitus, Type 1 · Continuous Glucose Monitoring
  Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1).Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study.

Elsewhere on this page

• Trial readout A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.

Representative papers

1. Prescribing Trajectories in Type 2 Diabetes in the United States, 2019-2024. Diabetes, obesity & metabolism
2. Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study. Diabetes research and clinical practice
3. U-500 regular insulin in automated insulin delivery systems for severe insulin resistance: A single-center retrospective cohort. Diabetes research and clinical practice
4. Variability in Intravenous Insulin Infusion Management in Italian Intensive Care Units: A National Cross-Sectional Survey of Reported Nursing Practice. Nursing in critical care
5. Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1). Diabetes research and clinical practice
6. Weight Loss-Dependent Changes in Body Composition and Bone Health in People With Obesity and Type 1 Diabetes Treated With Liraglutide, Semaglutide, or Tirzepatide. Diabetes/metabolism research and reviews
7. Associations of the bioimpedance-derived phase angle with early and advanced stages of dysglycemia: Cross-sectional findings from a large population-based study. Clinical nutrition (Edinburgh, Scotland)
8. Clinically relevant depression in patients with type 1 and type 2 diabetes; a nationwide study (TEMD-2 depression). Endocrine

Study types

Human study 3 · Animal (in vivo) 195 · In vitro / preclinical 3

Key concepts (papers in this area)

Signal Transduction 99 · Drugs, Chinese Herbal 42 · Ferroptosis 30 · Macrophages 30 · NF-kappa B 28 · Proto-Oncogene Proteins c-akt 25

Sub-areas (papers sharing 3+ concepts)

• 42 Proto-Oncogene Proteins c-akt · Signal Transduction · Phosphatidylinositol 3-Kinases
  Zhiwang decoction inhibits the inflammatory response and macrophage polarization in rheumatoid arthritis by mediating the PI3K/AKT phosphorylation pathway through cellular communication network factor 1.Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.
• 39 Ferroptosis · GPX4 · Phospholipid Hydroperoxide Glutathione Peroxidase
  Integrative transcriptomic and single-cell analyses identify CD74 as a candidate regulator of ferroptosis in renal tubular cells during nephrolithiasis.Acteoside alleviates high glucose-induced ROS accumulation and ferroptosis in ARPE-19 cells by activating the NRF2 signaling pathway.
• 22 Liver · Gastrointestinal Microbiome · Lipid Metabolism
  Multi-omics reveals the role of PPARα signaling in the treatment of hyperlipidemia with Qinlian Hongqu Decoction.Compound Dancao Granules inhibits lipid accumulation and hepatocyte apoptosis via the p53 signaling pathway in metabolic dysfunction-associated steatohepatitis mice.
• 19 NLR Family, Pyrin Domain-Containing 3 Protein · Inflammasomes · NLRP3 Inflammasome
  Gastrodia elata Blume and Acorus tatarinowii Schott mixtures alleviate pentylenetetrazol-induced seizures in mice: association with NLRP3 inflammasome signaling changes.Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2/NLRP3 inflammasome pathway.
• 18 Toll-Like Receptor 4 · NF-kappa B · Signal Transduction
  Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation.CCL5 mRNA-enriched small extracellular vesicles from renal tubular epithelial cells enhance macrophage inflammatory responses in diabetic nephropathy.
• 14 STAT3 Transcription Factor · STAT3 · Ovariectomy
  Guanxin Ⅱ alleviates atherosclerotic comorbid depression via modulating AKT1-STAT3-TLR4 axis and ATG3-mediated autophagy.Yupingfeng San extract ameliorates cisplatin induced renal interstitial fibrosis via IL-6/JAK/STAT3 mediated restoration of mitochondrial homeostasis.

Elsewhere on this page

• Key finding B8 Induces Tumor Regression in Hematologic Malignancies

Representative papers

1. α1-Antitrypsin attenuates microglial NLR family pyrin domain containing 3 inflammasome activation via cannabinoid receptor 2 signaling to ameliorate α-synucleinopathy-related behavioral deficits. Molecular biomedicine
2. Huanglian Jiedu decoction ameliorates hypertensive nephropathy by inhibiting the AGEs-RAGE/MAPK/AP-1 axis: An integrated transcriptomics and network pharmacology study. Journal of ethnopharmacology
3. Maternal exposure to polystyrene nanoplastics triggers ovarian injury in mice offspring: Ferroptosis mediated by the HIF-1α/HO-1 pathway. Reproductive toxicology (Elmsford, N.Y.)
4. SLC5A2-SRC-ERK/STAT3 signaling network in proximal tubule S1 cells mediates the renoprotective effects of dapagliflozin in obese mice. Biochemical and biophysical research communications
5. Yiqi Huoxue Lishui-based Optimized New Shengmai Powder ameliorates myocardial injury in rats with post-myocardial infarction heart failure by inhibiting oxidative stress-mediated ferroptosis via the cyclic guanosine monophosphate-protein kinase G-glutathione peroxidase 4 axis. Journal of ethnopharmacology
6. Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration. Journal of ethnopharmacology
7. A novel noncanonical Src-mammalian STE20-like kinase 1 (MST1)-Akt/glycogen synthase kinase-3β (GSK3β) pathway drives platelet activation and thrombosis. Journal of thrombosis and haemostasis : JTH
8. Elucidation of the mechanisms and therapeutic effects of Sini Decoction on anxiety induced by forced swimming stress in mice. Journal of ethnopharmacology

Study types

Randomized trial / meta-analysis 23 · Human study 129 · Animal (in vivo) 5 · In vitro / preclinical 2

Key concepts (papers in this area)

Biomarkers 43 · Cardiovascular Diseases 30 · Ischemic Stroke 24 · Myocardial Infarction 22 · Heart Failure 21 · Cholesterol, LDL 18

Sub-areas (papers sharing 3+ concepts)

• 32 Cardiovascular Diseases · Metabolic Syndrome · Cardiovascular–kidney–metabolic syndrome
  Haptoglobin and Immunoglobulin A2 Predict Cardiovascular Risk in Asymptomatic Subjects: The BioImage Study.Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study.
• 24 Stroke Volume · Ventricular Function, Left · Natriuretic Peptide, Brain
  Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery.Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts.
• 19 Predictive Learning Models · Machine Learning · Percutaneous Coronary Intervention
  Impact of Diabetes on Outcomes of Contemporary PCI Guided by OCT vs Angiography: The ILUMIEN IV Trial.Computed Tomographic Angiography-Based Radiomics Predicted Stroke Recurrence in Patients With Symptomatic Intracranial Atherosclerotic Stenosis.
• 18 Anticoagulants · Direct Oral Anticoagulants · Factor Xa Inhibitors
  Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial.Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk.
• 15 Cholesterol, LDL · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipid-lowering therapy
  Nationwide LDL-C goal attainment in high-risk and very-high-risk patients in Denmark: real-world lipid management and simulated impact of guideline implementation.Real-world use of bempedoic acid for hypercholesterolaemia: a German multicentre, retrospective, cohort study.
• 10 Fibrinolytic Agents · STROKE MEDICINE · National Institutes of Health Stroke Scale
  Butylphthalide combined with tenecteplase in mild disabling acute ischaemic stroke in China (BENEFIT-2): study protocol for a multicentre, randomised, double-blind, active-controlled trial.Clinical safety and preliminary efficacy of allogeneic human induced pluripotent stem cell-derived exosomes in patients with acute ischaemic stroke: protocol of a phase I/II clinical trial in China.

Elsewhere on this page

• Trial readout Add-On PCSK9 Inhibitor Therapy for Acute Stroke Attributable to Intracranial Atherosclerosis: A Randomized Clinical Trial.
• Trial readout Empagliflozin Promotes Natriuresis in Diabetic Patients with Cirrhotic Refractory Ascites: A Proof-of-Concept Study.

Representative papers

1. Haptoglobin and Immunoglobulin A2 Predict Cardiovascular Risk in Asymptomatic Subjects: The BioImage Study. Journal of the American Heart Association
2. Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. Cardiovascular diabetology
3. Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial. BMJ open
4. Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery. Journal of the American Heart Association
5. Nationwide LDL-C goal attainment in high-risk and very-high-risk patients in Denmark: real-world lipid management and simulated impact of guideline implementation. Open heart
6. API-CAT investigators' decisions on anticoagulation following extended treatment for cancer-associated thrombosis. European heart journal. Cardiovascular pharmacotherapy
7. Complex cardiac and porcelain aorta surgery in patients with untreated familial hypercholesterolaemia: a case report. Cardiovascular journal of Africa
8. Etiologic spectrum of direct oral anticoagulant breakthrough stroke in atrial fibrillation: The role of pseudo-failure and non-cardioembolic mechanisms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Study types

Randomized trial / meta-analysis 11 · Human study 130

Key concepts (papers in this area)

Neoplasms 43 · Cancer Survivors 18 · Patient-Centered Care 17 · Caregivers 14 · Digital Health 13 · Palliative Care 13

Sub-areas (papers sharing 3+ concepts)

• 17 Interviews as Topic · Oncology · Palliative Care
  Spiritual wellbeing in advanced cancer patients receiving palliative care in a tertiary cancer centre in northern Kerala, India: a qualitative study.Evaluating an innovative support programme for older long-term cancer survivors (IMPULS-A): protocol for a randomised controlled trial.
• 16 Cancer Survivors · Quality of Life · Symptom Burden
  Perception of fall risk among cancer survivors receiving Radiotherapy/Chemotherapy in China: A latent profile analysis.International phase IV field study to validate the European Organisation for Research and Treatment of Cancer questionnaire for assessing the health-related quality of life of cancer survivors: The EORTC QLQ-SURV100.
• 13 Attitude of Health Personnel · AI · Artificial Intelligence
  Clinician Perceptions of AI in Care: Cross-Sectional Survey.Facilitators and barriers to implementing a digital health-supported, community pharmacy-based prediabetes management program (PRIME program) in Malaysia: a qualitative study of participants' and pharmacists' perspectives.
• 10 Feasibility Studies · Research Design · Paediatric Oncology
  A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial.Feasibility of a remote and home-based personalised exercise programme in cancer survivors with lymphoedema.

Representative papers

1. A conceptual model of cancer care and lived experiences in adolescents and young adults with cancer: results from the multi-national European STRONG AYA project. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
2. Children's participation in assent to paediatric oncology research: experiences of children, siblings and parents. Trials
3. Prescriber Practices and Barriers to Providing Prescription Medication Instructions for Patients With a Non-English Language Preference. Annals of family medicine
4. Psychosocial and supportive care in radiation therapy: a qualitative comparison of Norway and Canada. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
5. Identifying components of a theory-informed complex intervention supporting primary care nurses to provide evidence-based dementia care in the general practice setting. Primary health care research & development
6. Perspectives of practitioners providing weight management support for young adults with obesity in an urban setting in Sri Lanka: a qualitative study. BMJ open
7. Informational needs in vulvar cancer and precursor conditions: a social listening study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
8. Patient Experiences With a Symptom Monitoring and Self-Referral Program for Specialty Palliative Care After Lung Cancer Diagnosis: Qualitative Study. JMIR formative research

Study types

Randomized trial / meta-analysis 1 · Human study 7 · Animal (in vivo) 97 · In vitro / preclinical 19

Key concepts (papers in this area)

Oxidative Stress 44 · Apoptosis 43 · Neuroinflammatory Diseases 23 · Alzheimer Disease 20 · Hippocampus 20 · Microglia 16

Sub-areas (papers sharing 3+ concepts)

• 29 Apoptosis · Bax · Bcl-2
  Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil-induced cardiotoxicity using kaempferol-mediated selenium nanoparticles.Development of dual A2AR/EGFR targeting pyrazoline-thiazole hybrids for restored apoptotic balance in colorectal cancer.
• 23 Oxidative Stress · Antioxidants · Plant Extracts
  Reactive oxygen species-scavenging hydrogels loaded with tempol exert anti-oxidative effects in spinal cord injury rat models.Neuroprotective Effects of Senecio brasiliensis Extract Against Chlorpyrifos-Induced Neurotoxicity and Oxidative Stress in Drosophila melanogaster.
• 19 Alzheimer Disease · Amyloid beta-Peptides · tau Proteins
  LPI alleviates Alzheimer's disease pathology via the GPR55 receptor.The neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer's disease like model in rat hippocampus: insights into neurogenesis and autophagy.
• 18 Cognitive Dysfunction · Neuroinflammatory Diseases · Hippocampus
  Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation.In vivo evaluation of the neuroprotective effects of melittin on doxorubicin-induced acute and chronic neurotoxicity in mice.
• 12 Structure-Activity Relationship · Molecular Structure · Dose-Response Relationship, Drug
  Sulfonamide-flavonoid analogue SG16 shows promise as a novel anti-inflammatory agent for ischemic stroke treatment.Design, synthesis, and biological evaluation of a multi-layer-linked idebenone derivative targeting mitochondrial dysfunction and neuroinflammation for ischemic stroke.

Representative papers

1. Triangulating the Neuroprotective Mechanisms of Pterostilbene in Hyperhomocysteinemia Induced Cognitive Impairment: Insights from In Silico, Proteomics, and Experimental Validation. Neuromolecular medicine
2. Neuroprotective impact of nicotinamide riboside and metformin on the hippocampus of male rats with diet-induced obesity. Metabolic brain disease
3. High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence. Experimental brain research
4. Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation. Molecular biology reports
5. Neuroprotective and cognitive-enhancing effects of γ-Oryzanol in bile duct ligation-induced hepatic encephalopathy in rats. Metabolic brain disease
6. BBB permeable selective HDAC3 inhibitor SP108 restores hippocampal plasticity and learning in a MAM-induced model of schizophrenia. Neuropharmacology
7. Resveratrol Ameliorates Brain Functions During Gestation in Mancozeb-Low-Dose-Induced Brain Disorders via Mitigating Inflammation, Lipid Peroxidation, Mitochondrial Dysfunction, DNA Damage, Cell Death, and Histopathological Alterations. Molecular neurobiology
8. Aging-modulatory effects of Pausinystalia macroceras (K. Schum.) Pierre polysaccharides are associated with DAF-16/FOXO and SKN-1/Nrf2 signaling in multiple aging models. Biogerontology

Study types

Randomized trial / meta-analysis 8 · Clinical trial 2 · Human study 93

Key concepts (papers in this area)

HIV Infections 22 · Anti-HIV Agents 12 · Antiretroviral Therapy 11 · Viral Load 10 · Liver Transplantation 8 · Medication Adherence 7

Sub-areas (papers sharing 3+ concepts)

• 9 HIV · Kenya · Anti-HIV Agents
  Analysis of a clinical pathway for the use of long-acting injectable antiretroviral therapy in adherence challenged people living with HIV.Safety, Pharmacokinetics, and Pharmacodynamics of Single-Dose Programmed Cell Death Protein 1 Inhibitor, Budigalimab, in People With HIV-1 With Antiretroviral Therapy-Suppressed Viral Load.
• 8 Piperazines · Pyridones · Heterocyclic Compounds, 3-Ring
  Weight Gain on Contemporary Integrase Strand Transfer Inhibitors and Tenofovir Alafenamide in Persons With HIV Starting Antiretroviral Therapy in the United States and Canada.Predictors of Treatment Failure in Children With HIV Starting First-line Antiretroviral Therapy in the ODYSSEY Trial.
• 6 Vaccination · Influenza, Human · Influenza Vaccines
  Peak Nasal SARS-CoV-2 and Influenza Viral Loads Relative to Symptom Onset, 2022-2025: Impact of Vaccination and Implications for Multiplexed Testing.Influenza Vaccine Effectiveness Against Mild and Severe Outcomes: A Comparison Study in Portugal.
• 5 Living Donors · Liver Transplantation · Biliary Atresia
  Outcome of Pediatric Living Donor Liver Transplantation for Cholestatic Liver Disease in Different Body Weight Groups. A Retrospective Cohort Study.Thickness Reduction Versus Conventional Left Lateral Sector Strategies in Children Below 8 kg Undergoing Living Donor Liver Transplantation.

Representative papers

1. Weight Gain on Contemporary Integrase Strand Transfer Inhibitors and Tenofovir Alafenamide in Persons With HIV Starting Antiretroviral Therapy in the United States and Canada. The Journal of infectious diseases
2. Low-Level Viremia and Spatial Heterogeneity Among Individuals on Dolutegravir-Based Antiretroviral Therapy in Botswana: A Nationwide Study (2016-2022). The Journal of infectious diseases
3. Predictors of Treatment Failure in Children With HIV Starting First-line Antiretroviral Therapy in the ODYSSEY Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
4. Coxsackievirus B Infections Are Associated With the Risk of Islet Autoimmunity in Children With Strong Genetic Susceptibility to Type 1 Diabetes-Results From the TRIGR Divia Study. Diabetes/metabolism research and reviews
5. Pediatric Human Immunodeficiency Virus Infections Admissions and Outcome at Wesley Guild Hospital, Ilesa, Nigeria. Annals of African medicine
6. Adherence to antiretroviral therapy and drug resistance impact evolving viral suppression among a cohort of children and adolescents living with perinatal HIV infection in western Kenya. PloS one
7. Thickness Reduction Versus Conventional Left Lateral Sector Strategies in Children Below 8 kg Undergoing Living Donor Liver Transplantation. Pediatric transplantation
8. Twenty-four month effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide in people with HIV: Real-world data from the BICSTaR Japan cohort. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Study types

Randomized trial / meta-analysis 1 · Human study 7 · Animal (in vivo) 79 · In vitro / preclinical 13

Key concepts (papers in this area)

Anti-Inflammatory Agents 28 · Plant Extracts 28 · Inflammation 27 · TNF-α 26 · Cytokines 18 · IL-6 16

Sub-areas (papers sharing 3+ concepts)

• 24 Inflammation · IL-6 · TNF-α
  In vivo and molecular docking studies of Micromeria imbricata var. imbricata extract reveal alleviation of the DSS-induced IBD phenotype via interaction with key inflammatory mediators.Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis.
• 16 Phytochemicals · Plant Extracts · Antioxidants
  Phytoextract-loaded bioinspired PLGA nanofibrous scaffold promotes diabetic wound healing via anti-inflammatory and antioxidant effects in in vitro and in vivo experimental models.Phytochemical and anti-inflammatory profiling of Amomum maximum Roxb. Fruits reveal undescribed diarylheptanoids and labdane diterpenoids.
• 14 Interleukin-6 · Interleukin-1beta · Interleukin-8
  Ellagic acid regulates astrocytic responses under inflammatory conditions in primary astrocyte cultures: effects on oxidative stress, inflammatory cytokines, and glycogen synthase kinase-3β.Chemical profiling of Egregia menziesii and anti-inflammatory potential in LPS-activated RAW 264.7 macrophages.
• 13 Structure-Activity Relationship · Molecular Structure · Dose-Response Relationship, Drug
  Bioassay-guided discovery of anti-inflammatory sesquiterpenoids from Lindera aggregata (Sims) Kosterm.Structure-Guided Optimization of PDE9A Inhibitors Tackling Neuroinflammation: A Combined Computational and In Vitro Study.
• 7 Tandem Mass Spectrometry · Chromatography, High Pressure Liquid · Constipation
  Mechanistic Insights Into the Anti-Constipation Potential of Xiaogan Jianwei Formula: Integration of HPLC-Q-TOF MS/MS, Network Pharmacology, In Vivo Validation, and Gut Microbiota.Metabolomic Characterization of 16 Malpighiaceae Species From Brazilian Biomes by UHPLC-MS/MS and PCA.

Representative papers

1. In vivo and molecular docking studies of Micromeria imbricata var. imbricata extract reveal alleviation of the DSS-induced IBD phenotype via interaction with key inflammatory mediators. Journal of ethnopharmacology
2. Protective and therapeutic roles of Phoenix dactylifera L. Zaghloul cultivar leaves extract against ethanol-induced gastric ulcer in rats. Journal of molecular histology
3. Exploring GC-MS-Based Phytochemistry and Network Pharmacology to Elucidate the Multi-Target Therapeutic Potential of Betel Leaf Oil as an Analgesic and Anti-Inflammatory Agent. Biomedical chromatography : BMC
4. Bioassay-guided discovery of anti-inflammatory sesquiterpenoids from Lindera aggregata (Sims) Kosterm. Bioorganic chemistry
5. Anti-inflammatory, wound healing, and hepatoprotective effects of Acampe papillosa (Lindl.) Lindl. seed in wistar rats: insights from biochemical, histopathological, and in silico investigations. Journal of molecular histology
6. Phytochemical and anti-inflammatory profiling of Amomum maximum Roxb. Fruits reveal undescribed diarylheptanoids and labdane diterpenoids. Fitoterapia
7. Enzymatic preparation of luteolin-rich olive (Olea europaea L.) leaf extract and its inhibitory effects on colitis. Bioorganic chemistry
8. Exploring the mechanism of Panax notoginseng injection in the treatment of skin wound based on network pharmacology and experimental verification. Journal of molecular histology

Study types

Human study 11 · Animal (in vivo) 53 · In vitro / preclinical 31

Key concepts (papers in this area)

Anti-Bacterial Agents 72 · Microbial Sensitivity Tests 51 · Biofilms 28 · Staphylococcus aureus 23 · Escherichia coli 20 · Pseudomonas aeruginosa 15

Sub-areas (papers sharing 3+ concepts)

• 37 Wound Healing · Anti-Bacterial Agents · Biofilms
  Chemical Reduction-Derived Nickel Nanoparticles as Multifunctional Antimicrobial and Wound Healing Agents: Mechanistic, Biocompatibility, and Computational Insights.Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration.
• 29 Structure-Activity Relationship · Dose-Response Relationship, Drug · Molecular Structure
  Design and synthesis of novel baicalein-isoxazoles based scaffolds and their anti-microbial potential: in vitro and in silico evaluation.Insights into novel benzo[h]quinoline-based 2-thioxothiazolidin-4-one and thiazol-4-one hybrids as potential antimicrobial, and antibiofilm candidates: Design, synthesis, molecular modeling, and in-silico ADME studies.
• 10 Bacterial Proteins · Klebsiella pneumoniae · beta-Lactamases
  An integrative computational and experimental evaluation of natural compounds with potential to target LuxS in Klebsiella pneumoniae.The role of biosynthesized zinc oxide nanoparticles in modulating the expression of virulence factors in multidrug-resistant Klebsiellapneumoniae.
• 10 Materials Testing · Biocompatible Materials · Particle Size
  Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices.Metal Ion-Triggered Collapsed Hydrogels as Materials for Bacterial Population Control.

Representative papers

1. Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices. ACS applied bio materials
2. Self-Assembling Amphiphilic Cationic Peptide-Based Nanoarchitectures for Soft Biomaterials with Potential Antimicrobial Activity against Clinically Isolated Multidrug-Resistant Bacteria. ACS applied bio materials
3. Insights into novel benzo[h]quinoline-based 2-thioxothiazolidin-4-one and thiazol-4-one hybrids as potential antimicrobial, and antibiofilm candidates: Design, synthesis, molecular modeling, and in-silico ADME studies. Bioorganic chemistry
4. Design, synthesis and biological evaluation of proline-arginine rich hybrid peptides against ESKAPE pathogens by inhibiting bacterial protein synthesis and DNA replication. Bioorganic chemistry
5. Design, synthesis and antibacterial evaluation of novel unsaturated butenolide-fatty amine hybrids against multidrug-resistant pathogens. Bioorganic & medicinal chemistry letters
6. Performance optimization of ultrashort antimicrobial peptides through backbone amide cyclization. European journal of medicinal chemistry
7. Design and synthesis of novel baicalein-isoxazoles based scaffolds and their anti-microbial potential: in vitro and in silico evaluation. Bioorganic chemistry
8. Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration. Scientific reports

Study types

Randomized trial / meta-analysis 1 · Human study 27 · Animal (in vivo) 33 · In vitro / preclinical 20

Key concepts (papers in this area)

Limit of Detection 37 · Biosensing Techniques 33 · Metal Nanoparticles 32 · Gold 21 · Electrochemical Techniques 20 · Gold Nanoparticles 16

Sub-areas (papers sharing 3+ concepts)

• 19 Gold Nanoparticles · Gold · Metal Nanoparticles
  Freeze-thaw-directed interfacial assembly of a gold nanoparticle/MXene electrochemical aptamer sensor for antibody-free myeloperoxidase detection.Gold-graphene based nanofiber biosensor for selective electrochemical identification of CD105-positive canine mesenchymal stem cells.
• 16 Electrochemical Techniques · Biosensing Techniques · Luminescent Measurements
  Aptakiss-guided CRISPR/Cas13a signal amplification for ultrasensitive FEN1 detection using CsPbBr3@PDA@AuNPs-based electrochemiluminescence platform.A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone.
• 11 Spectrometry, Fluorescence · Fluorescent Chemosensor Compounds · Colorimetry
  Molecular-level biomimetic integration of phosphorus-doped graphene quantum dots with silver nanoparticles for highly stable and active nanozymes: Application in ultrasensitive ascorbic acid detection.A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles.
• 10 Optical Imaging · Infrared Rays · Neoplasms
  Donor-engineered and H-aggregated squaraine-nanoprobe triggering tumor NIR-II fluorescence imaging with larger Stokes shift and type I photodynamic/photothermal synergistic therapy.Non-fused ring A-D-A-type dyes for near-infrared II fluorescence imaging guided phototherapy and immune activation of tumour.
• 7 Silver Nanoparticles · Silver · Plant Extracts
  Phytochemical profiling-guided green synthesis and characterisation of silver nanoparticles using Catunaregam spinosa for biological applications.Influence of thermal treatment on the physicochemical, biological, and ecotoxicological properties of plant-mediated metal and metal-oxide nanoparticles.
• 5 Zinc Oxide · Differential pulse voltammetry · Carbon paste electrode
  Chemiluminescence functionalized magnetic nanoparticles-based biosensor for sensitive detection of glucose, uric acid, and cholesterol.Electrochemical sensor modified with nickel-doped zinc oxide nanoparticles for sensitive monitoring of rizatriptan benzoate in human plasma.

Representative papers

1. A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles. Analytica chimica acta
2. Sustainable Synthesis of N, S-Enriched Carbon Sensor from Euphorbia royleana Latex for Low-Cost Fluorescence Based Detection of Arsenic Ions. Bulletin of environmental contamination and toxicology
3. Aptakiss-guided CRISPR/Cas13a signal amplification for ultrasensitive FEN1 detection using CsPbBr3@PDA@AuNPs-based electrochemiluminescence platform. Biosensors & bioelectronics
4. Interfacial tripedal DNA walking coupled with oxygen-depletion/ECL-RET dual quenching for femtomolar detection of Tobacco Mosaic Virus RNA in plant extracts. Mikrochimica acta
5. Ion-induced plasmonic microneedle patches for ultrasensitive SERS detection hemoporfin in interstitial fluids. Biosensors & bioelectronics
6. A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone. Mikrochimica acta
7. A Dual-Mode Fluorescent and Colorimetric Biosensor Based on AuNPs@RCA Nanogel-Integrated Multipedal DNA Walker for Ultrasensitive miRNA Detection. ACS applied materials & interfaces
8. Design and fabrication of a platform for circulating tumor cells (CTCs) isolation and detection by MiRGD@NTA@Au-Fe3O4 nanoparticles. Biosensors & bioelectronics

Study types

Randomized trial / meta-analysis 22 · Clinical trial 1 · Human study 55 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Depression 23 · Quality of Life 21 · Anxiety 18 · Pain Measurement 12 · Fatigue 11 · Sleep Quality 8

Sub-areas (papers sharing 3+ concepts)

• 9 Stress, Psychological · Anxiety · Neoplasms
  Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer.Functional electrical stimulation for major depressive disorder: Protocol for a pilot randomized controlled trial.
• 9 Quality of Life · Antineoplastic Agents · Fatigue
  Effects of transcutaneous electrical acupoint stimulation versus acupressure on the trajectories of multidimensional adverse reactions to chemotherapy in breast cancer patients: a secondary analysis of a randomized controlled trial.Effectiveness of Yoga and Combined Exercise in Female With Rheumatoid Arthritis: Randomized Controlled Trial.
• 9 Multicenter Studies as Topic · Pain Measurement · Randomized Controlled Trials as Topic
  Effectiveness of Tuina Therapy for Patients With Chronic Fatigue Syndrome: Protocol for a Multicenter, Randomized, Open-Label, Assessor-Blinded, Parallel-Group Clinical Trial.Randomised comparative effectiveness trial evaluating the efficacy and safety of acupuncture-related integrative therapy combined with celecoxib for chronic pain in patients with knee osteoarthritis: protocol.

Elsewhere on this page

• Trial readout Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.

Representative papers

1. Improving Sleep and PTSD Outcomes in Service Members: A Randomized Controlled Trial Examining the Long-Term Effects of an Integrated Treatment. Behavior therapy
2. Ketamine assisted psychotherapy to reduce chronic neuropathic pain: A mixed-methods randomized pilot trial. Med (New York, N.Y.)
3. Effects of transcutaneous electrical acupoint stimulation versus acupressure on the trajectories of multidimensional adverse reactions to chemotherapy in breast cancer patients: a secondary analysis of a randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
4. The role of the transdiagnostic sleep and circadian intervention in adolescent bedtime and sleep quality: a pilot study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
5. Effect of active noise-cancelling headphones combined with music therapy on postoperative recovery quality after general anaesthesia for ankle fracture ORIF: a study protocol for a single-centre, four-arm 2×2 factorial randomised controlled trial in China. BMJ open
6. Exploring key targets for psychodiabetological interventions in adults with type 1 diabetes mellitus: an exploratory network and intervention modeling study using Polish MyDiaMate data. Diabetes research and clinical practice
7. The Effect of Aromatherapy on Fatigue and Sleep Quality in Intensive Care Nurses: A Randomised Placebo-Controlled Trial. Nursing in critical care
8. Effectiveness of Yoga and Combined Exercise in Female With Rheumatoid Arthritis: Randomized Controlled Trial. Musculoskeletal care

Study types

Clinical trial 6 · Human study 23 · Animal (in vivo) 40 · In vitro / preclinical 5

Key concepts (papers in this area)

Immunotherapy, Adoptive 38 · T-Lymphocytes 34 · Receptors, Chimeric Antigen 31 · Multiple Myeloma 15 · Killer Cells, Natural 12 · CAR T cells 10

Sub-areas (papers sharing 3+ concepts)

• 19 CAR T cells · Xenograft Model Antitumor Assays · Immunotherapy, Adoptive
  CAR T Cells Targeting O-Glycosylated Fibronectin Exhibit Potent Cytolytic Activity and Combine with Tumoral Toll-Like Receptor Agonism to Overcome Tumor Resistance.CCL19-armed oncolytic adenovirus synergizes with CCR7-expressing CAR-T cells to suppress ovarian tumor growth.
• 19 T-Lymphocytes · Antigens, CD19 · Immunotherapy, Adoptive
  Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells.Hattrick against Lymphoma with Trispecific CAR T Cells.
• 11 Multiple Myeloma · ciltacabtagene autoleucel · Idecabtagene vicleucel
  A novel triple-knockout allogeneic BCMA CAR T-cell therapy (CT0590) for multiple myeloma: preclinical and phase 1 study.Phase 1 Study of Anito-cel, a d-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma.
• 9 Serine Endopeptidases · Gelatinases · Fibroblast Activation Protein Alpha
  The FAP × CD3 bispecific antibody OMTX305 induces T cell-mediated antitumor effects in patient-derived ex vivo models of solid tumors.Dual bispecific protein engager-armed T cells targeting BCMA and B7-H3 overcome antigen heterogeneity in multiple myeloma.

Representative papers

1. Antibody format matters: A comparative analysis of VHH and scFv domains reveals superior in vivo CAR T cell function with VHH domains. Molecular therapy : the journal of the American Society of Gene Therapy
2. Gene regulatory elements determine efficacy of BCMA-targeted CAR-T cell products. Journal for immunotherapy of cancer
3. Dual bispecific protein engager-armed T cells targeting BCMA and B7-H3 overcome antigen heterogeneity in multiple myeloma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
4. Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells. Molecular therapy : the journal of the American Society of Gene Therapy
5. Hattrick against Lymphoma with Trispecific CAR T Cells. Blood cancer discovery
6. Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies. Cancer cell
7. Safety and Clinical Outcomes of a First-in-Human Trial of Point-of-Care Manufactured Trispecific CAR T Cells Targeting CD19, CD20, and CD22. Blood cancer discovery
8. CAR T Cells Targeting O-Glycosylated Fibronectin Exhibit Potent Cytolytic Activity and Combine with Tumoral Toll-Like Receptor Agonism to Overcome Tumor Resistance. Cancer immunology research

Study types

Randomized trial / meta-analysis 2 · Clinical trial 1 · Human study 58

Key concepts (papers in this area)

Research Design 15 · Cost-Effectiveness Analysis 12 · Cost-Benefit Analysis 12 · Hospitalization 10 · Quality-Adjusted Life Years 6 · Anastomotic Leak 3

Sub-areas (papers sharing 3+ concepts)

• 14 Cost-Effectiveness Analysis · Cost-Benefit Analysis · Robotic Surgical Procedures
  Health technology assessment of robotic surgery for rectal cancer in China: protocol for a nationally multicentre prospective cohort study.Affordability of innovation: cost-effectiveness and budget impact analysis of acoramidis in transthyretin amyloid cardiomyopathy in the German healthcare system.
• 9 Vaccination · Respiratory Syncytial Virus Infections · Respiratory Syncytial Virus Vaccines
  Clinical and economic impact of bivalent respiratory syncytial virus prefusion F (RSVpreF) vaccination in older adults: a cost-effectiveness analysis for Chile.Evaluating the cost-effectiveness of respiratory syncytial virus vaccination among risk-stratified older adults.
• 6 Stress, Psychological · Coping Skills · Adaptation, Psychological
  Examining the Relationship Between Earthquake-Induced Stress and Chronic Disease Management in Parents of Diabetic Children in Turkey.Intensive longitudinal assessment of stress and stress-related concepts across a weight loss program: Protocol for a longitudinal ecological momentary assessment study.

Representative papers

1. Nutritional knowledge, attitudes, and practices (KAP) and GLIM-defined malnutrition in hospitalized head and neck cancer patients receiving surgical treatment: A cross-sectional study in china. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
2. Clinical and economic impact of bivalent respiratory syncytial virus prefusion F (RSVpreF) vaccination in older adults: a cost-effectiveness analysis for Chile. Expert review of vaccines
3. Health technology assessment of robotic surgery for rectal cancer in China: protocol for a nationally multicentre prospective cohort study. BMJ open
4. Modified single-stapled anastomosis in laparoscopic or robotic low anterior resection for rectal cancer: protocol for a multicentre randomised controlled trial. BMJ open
5. Cost-effectiveness analysis of efavirenz versus ainuovirine in people living with HIV initiating first-line combination antiretroviral therapy. BMJ open
6. Assessing the consistency of overall survival extrapolations in Swedish health technology assessment reports of oncology treatments using extended follow-up data. Journal of medical economics
7. Methods and evidence in economic evaluations of modern radiotherapy: a systematic mapping review protocol. BMJ open
8. Examining the Relationship Between Earthquake-Induced Stress and Chronic Disease Management in Parents of Diabetic Children in Turkey. Research and theory for nursing practice

Study types

Randomized trial / meta-analysis 1 · Clinical trial 1 · Human study 22 · Animal (in vivo) 33 · In vitro / preclinical 2

Key concepts (papers in this area)

Tumor Microenvironment 40 · Immunotherapy 29 · CD8+ T cells 14 · PD-1 14 · PD-L1 10 · Lymphocytes, Tumor-Infiltrating 9

Sub-areas (papers sharing 3+ concepts)

• 15 Gene Expression Profiling · Tumor Microenvironment · Lymphocytes, Tumor-Infiltrating
  Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy.The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression.
• 11 Immune Checkpoint Inhibitors · B7-H1 Antigen · Stomach Neoplasms
  Differential peripheral immune dynamics underlie therapeutic response to chemotherapy and chemoimmunotherapy in triple-negative breast cancer.PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype.
• 10 Neoplasms · Immunotherapy · Cytoskeleton
  Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses.Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization.
• 9 Immunotherapy · cGAS-STING Signaling Pathway · T-Lymphocytes
  Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.Lactobacillus salivarius potentiates gastrointestinal cancer immunotherapy through its metabolite chenodeoxycholic acid.
• 7 Antineoplastic Agents · M2 Macrophages · NF-κB Pathway
  A Liposomal Nanovaccine Reprograms Post-Ablation Macrophages to Sustain Antitumor Immunity in Hepatocellular Carcinoma.\"Alkaline-Hammer Strategy\" Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer.

Representative papers

1. Profiling tumor immune microenvironment of epithelial ovarian carcinoma. Oncoimmunology
2. \"Alkaline-Hammer Strategy\" Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer. Angewandte Chemie (International ed. in English)
3. Efficacy and mechanism of topical Chinese herbal formulation JieZe-1 on female lower genital tract co-infection with HSV-2 and Candida albicans via upregulating the cGAS/STING/IFN-I pathway. Journal of ethnopharmacology
4. Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy. Oncoimmunology
5. Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses. Cell reports. Medicine
6. Tumor-specific immunological and pathological changes in layer chickens affected with ovarian adenocarcinoma. Developmental and comparative immunology
7. GPI promotes immunosuppression in anaplastic thyroid carcinoma via O-GlcNAcylated THBS1-mediated myeloid cell crosstalk. Cancer letters
8. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell

Study types

Human study 2 · Animal (in vivo) 45 · In vitro / preclinical 9

Key concepts (papers in this area)

Mesenchymal Stem Cells 20 · Exosomes 17 · Cell Differentiation 10 · Cellular Senescence 9 · Extracellular Vesicles 6 · Osteogenesis 6

Sub-areas (papers sharing 3+ concepts)

• 9 MicroRNAs · Antineoplastic Agents · Exosomes
  Induction and propagation of ferroptosis evasion by FTH1P7 drives sorafenib resistance in hepatocellular carcinoma.Tetrastigma hemsleyanum ELN-derived miR-396b suppresses pancreatic cancer cell proliferation by targeting IL33.
• 9 Osteogenesis · Cell Differentiation · Stem Cells
  3D-printed PCL/nHA/SA/COL loaded with M2 macrophage-derived exosomes alleviates the senescence of bone marrow mesenchymal stem cells.Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications.
• 8 Mesenchymal Stem Cell Transplantation · Mesenchymal Stem Cells · Glial Cell Line-Derived Neurotrophic Factor
  Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model.Mesenchymal stem cells from Cerdocyon thous: in vitro characterization and therapeutic potential.
• 7 Polymers · Nanoparticles · Reactive Oxygen Species
  Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells.A dual-responsive nanosystem for synergistic antibacterial therapy and inflammatory microenvironment modulation in infected diabetic wound healing.

Representative papers

1. Shockwave-Induced Myoblast Exosome-Like Vesicles: Emerging Drivers of Muscle Regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2. Silica nanoparticles suppress porcine oocyte maturation via oxidative stress, metabolic dysfunction, and impaired cholesterol trafficking. Theriogenology
3. Human umbilical cord mesenchymal stem cells enhance folliculogenesis and fertility in premature ovarian failure mice via regulating steroid synthesis. Stem cells (Dayton, Ohio)
4. hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle-Activating Capacity. Aging cell
5. Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
6. Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications. Journal of dentistry
7. Ginsenoside Rh2 from ginseng exosomes enhances chemotherapy sensitivity in non-small cell lung cancer by modulating the USP22-RRM2 axis. Cellular signalling
8. HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma. Molecular biomedicine

Study types

Randomized trial / meta-analysis 5 · Clinical trial 5 · Human study 18 · Animal (in vivo) 21 · In vitro / preclinical 6

Key concepts (papers in this area)

Lung Neoplasms 43 · Carcinoma, Non-Small-Cell Lung 36 · ErbB Receptors 23 · Drug Resistance, Neoplasm 21 · Protein Kinase Inhibitors 20 · Cisplatin 14

Sub-areas (papers sharing 3+ concepts)

• 23 ErbB Receptors · Mutation · Protein Kinase Inhibitors
  Afatinib Overcomes Osimertinib Resistance via Egfr V804F Mutation in a Syngeneic Egfr-Mutant Lung Cancer Mouse Model.A four-gene signature identifies TKI-induced persister cells and uncovers a ZLN005-induced pyroptotic vulnerability via the GSDME pathway in EGFR-mutant lung cancer.
• 18 Drug Resistance, Neoplasm · Cisplatin · Xenograft Model Antitumor Assays
  Activation of the NF-κB/ALDH1A1 signaling promotes non-mutational resistance to EGFR-TKIs in non-small cell lung cancer.Tumor cell-intrinsic NSUN2 deficiency reprograms macrophages to sensitize non-small cell lung cancer to EGFR inhibitors by reversing immune evasion.
• 8 Immunotherapy · Immune Checkpoint Inhibitors · NSCLC
  Development of novel nanoliposomes co-loaded with ROR1 inhibitor and Ce6 for the treatment of EGFR-TKIs resistant NSCLC by synergistic targeted inhibitor therapy and photodynamic therapy.PARP inhibition enhances the antitumor activity of HER3-DXd in non-small cell lung cancer.

Elsewhere on this page

• Trial readout Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.

Representative papers

1. Afatinib Overcomes Osimertinib Resistance via Egfr V804F Mutation in a Syngeneic Egfr-Mutant Lung Cancer Mouse Model. Cancer science
2. A four-gene signature identifies TKI-induced persister cells and uncovers a ZLN005-induced pyroptotic vulnerability via the GSDME pathway in EGFR-mutant lung cancer. Molecular medicine reports
3. Central Nervous System Activity of Lazertinib in EGFR-Mutated NSCLC With Prior EGFR TKI Exposure: A Pooled Analysis of KCSG-LU20-15 and LU21-01. Thoracic cancer
4. Tumor cell-intrinsic NSUN2 deficiency reprograms macrophages to sensitize non-small cell lung cancer to EGFR inhibitors by reversing immune evasion. Neoplasia (New York, N.Y.)
5. Adding local gyro-knife radiotherapy to EGFR-TKI improves outcomes in EGFR-mutant NSCLC. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
6. Targeting ALDH2 with Alda-1 to reverse cisplatin resistance in lung adenocarcinoma. Cancer chemotherapy and pharmacology
7. Clinical characteristics and management of Li-Fraumeni syndrome-associated lung cancer. Lung cancer (Amsterdam, Netherlands)
8. Development of novel nanoliposomes co-loaded with ROR1 inhibitor and Ce6 for the treatment of EGFR-TKIs resistant NSCLC by synergistic targeted inhibitor therapy and photodynamic therapy. Journal of photochemistry and photobiology. B, Biology