This month in biomedical research, distilled from PubMed. Updated 2026.09.30.

Study types

Randomized trial / meta-analysis 1 · Human study 25 · Animal (in vivo) 207 · In vitro / preclinical 64

Key concepts (papers in this area)

Nanoparticles 91 · Hydrogels 74 · Anti-Bacterial Agents 64 · Drug Delivery Systems 57 · Reactive Oxygen Species 51 · Wound Healing 47

Sub-areas (papers sharing 3+ concepts)

• 89 Drug Carriers · Drug Liberation · Drug Delivery Systems
  Formulation, Optimization and Characterization of Acetazolamide-Loaded Solid Lipid Nanoparticles for Glaucoma Treatment: In-Vitro and In-Vivo Study.pH-Responsive Chitosan-Coated Spanlastic Nanovesicles for Enhanced Lung-Targeted Delivery of Brilliant Blue G in Acute Lung Injury.
• 72 Anti-Bacterial Agents · Microbial Sensitivity Tests · Staphylococcus aureus
  A novel borneol-loaded PLGA/Chitosan nanoparticles: Synthesis, characterization and evaluation of antioxidant, antibacterial, wound healing and cytotoxic activity on A549 cells.Alginate-coated ZIF-8 and PCN-222 metal-organic frameworks for controlled delivery of a benzanthrone derivative: Structure-function relationships, release kinetics, and antibacterial mechanisms.
• 55 Photosensitizing Agents · Photochemotherapy · Tumor Microenvironment
  Strained alkyne functionalization of carbon dots enables selective photodynamic killing of Gram-positive bacteria.ZIF-90-PQ-based cascade nanoplatform for multimodal cooperative treatment of breast cancer.
• 46 Biocompatible Materials · Hydrogels · Materials Testing
  Photothermal-responsive dexmedetomidine-loaded MPDA-GelMA hydrogel promotes bone regeneration.Metal Ion-Triggered Collapsed Hydrogels as Materials for Bacterial Population Control.

Elsewhere on this page

• Key finding Intranasal SLNs Reduce Glioblastoma Volume

Representative papers

1. Alginate-coated ZIF-8 and PCN-222 metal-organic frameworks for controlled delivery of a benzanthrone derivative: Structure-function relationships, release kinetics, and antibacterial mechanisms. International journal of biological macromolecules
2. A multi-functional microneedle patch loaded with mupirocin and L-arginine nanoparticles for enhancing antibacterial activity, anti-inflammation and diabetic wound healing. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
3. Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing. Drug delivery
4. Manganese Dioxide Nanozyme-Constituted Composite Hydrogel to Scavenge Reactive Oxygen Species for Scarless Wound Healing. ACS applied materials & interfaces
5. Non-cytotoxic cellulose acetate butyrate composite membrane incorporating a WS2/ZnAl-LDH hybrid for controlled curcumin delivery toward wound dressing applications. International journal of biological macromolecules
6. Organelle-Resolved Tetrazine-trans-Cyclooctene Click Chemistry for Cargo Delivery and Release. Chemistry (Weinheim an der Bergstrasse, Germany)
7. Engineering injectable alginate hydrogels for mesenchymal stem cell delivery: comparative evaluation of ionic crosslinking strategies and earlyin vitrooutcomes. Biomedical materials (Bristol, England)
8. Efficient Antimicrobial Nanoenzymatic Functionalized Hydrogels for Diabetic Infected Wound Treatment. ACS biomaterials science & engineering

Study types

Human study 6 · Animal (in vivo) 266 · In vitro / preclinical 8

Key concepts (papers in this area)

Signal Transduction 101 · Oxidative Stress 73 · Inflammation 56 · Neuroinflammatory Diseases 38 · Macrophages 36 · NF-kappa B 36

Sub-areas (papers sharing 3+ concepts)

• 78 Signal Transduction · Drugs, Chinese Herbal · Network Pharmacology
  Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis.Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.
• 63 Antioxidants · Oxidative Stress · Plant Extracts
  Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes.Ellagic acid regulates astrocytic responses under inflammatory conditions in primary astrocyte cultures: effects on oxidative stress, inflammatory cytokines, and glycogen synthase kinase-3β.
• 60 Neuroinflammatory Diseases · Hippocampus · Cognitive Dysfunction
  Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation.Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation.
• 30 Toll-Like Receptor 4 · Interleukin-6 · NF-kappa B
  CCL5 mRNA-enriched small extracellular vesicles from renal tubular epithelial cells enhance macrophage inflammatory responses in diabetic nephropathy.Chemical profiling of Egregia menziesii and anti-inflammatory potential in LPS-activated RAW 264.7 macrophages.
• 17 Ferroptosis · GPX4 · Fibrosis
  MCL inhibits macrophage ferroptosis through the NRF2/HO-1/GPX4 axis to attenuate carotid atherosclerotic plaque formation.Acteoside alleviates high glucose-induced ROS accumulation and ferroptosis in ARPE-19 cells by activating the NRF2 signaling pathway.
• 5 Inflammatory Pathways · Fasudil · 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
  Fasudil induces anti-inflammatory transcriptomic changes and increased proliferation in human trisomy 21 neural progenitor cells.Tempol Attenuates Diabetes-induced Transcriptomic Changes in the Rat Retina.

Elsewhere on this page

• Key finding B8 PROTAC Induces Tumor Regression
• Key finding HITMAN Therapy for Glioblastoma

Representative papers

1. Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis. Fitoterapia
2. In vivo and molecular docking studies of Micromeria imbricata var. imbricata extract reveal alleviation of the DSS-induced IBD phenotype via interaction with key inflammatory mediators. Journal of ethnopharmacology
3. Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation. Molecular neurobiology
4. Integrated GNPS Molecular Networking and Network Pharmacology Uncover Methylophiopogonanone B as a Novel Anti-Inflammatory Agent From Polygonatum cyrtonema Hua Targeting the SRC-PI3K-Akt Pathway. Biomedical chromatography : BMC
5. Procyanidin B2 ameliorates hypoxic-ischemic brain damage in neonatal rats by inhibiting pyroptosis via the TLR4/NF-κB signaling pathway. International immunopharmacology
6. From grey relational-network pharmacology screening to mechanism elucidation: 4-methoxy-2- (3-methylethoxyethane) -phenylisobutyrate from Pimpinella diversifolia essential oil alleviates D-GalN/LPS-induced ALI by targeting the GSK-3β/NF-κB axis. Journal of ethnopharmacology
7. Protective and therapeutic roles of Phoenix dactylifera L. Zaghloul cultivar leaves extract against ethanol-induced gastric ulcer in rats. Journal of molecular histology
8. Exploring the mechanism of Panax notoginseng injection in the treatment of skin wound based on network pharmacology and experimental verification. Journal of molecular histology

Study types

Human study 24 · Animal (in vivo) 139 · In vitro / preclinical 96

Key concepts (papers in this area)

Antineoplastic Agents 158 · Structure-Activity Relationship 153 · Cell Proliferation 137 · Molecular Structure 136 · Dose-Response Relationship, Drug 129 · Apoptosis 90

Sub-areas (papers sharing 3+ concepts)

• 82 Drug Screening Assays, Antitumor · Cell Proliferation · Structure-Activity Relationship
  Novel Steroidal (Thio)barbiturate Hybrids: From Design to Preclinical Assessment in Tumor Therapy.Design and development of 2,7-disubstituted 6-methoxyquinazolin-4 (3H)-ones as potential anti-cancer agents possibly through downregulation of Wnt/β-catenin/TCF4 signaling pathway.
• 74 Xenograft Model Antitumor Assays · Cell Survival · Apoptosis
  Biphenyl sulfonylurea Analogs as novel antiangiogenic agents: A repositioning and molecular modelling strategy.New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation.
• 58 Molecular Dynamics Simulation · Molecular Structure · Dose-Response Relationship, Drug
  Discovery of new thiazolyl hydrazone derivatives as anti-breast cancer agents: Synthesis, biological evaluation and in silico studies.Antineoplastic multi-targeted spiro[indoline-3,2'-pyrrolidines] incorporating urea function: Rational design, synthesis and bio-properties studies.
• 38 Protein Kinase Inhibitors · ErbB Receptors · EGFR
  Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies.Development of dual A2AR/EGFR targeting pyrazoline-thiazole hybrids for restored apoptotic balance in colorectal cancer.

Representative papers

1. Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies. Bioorganic chemistry
2. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry
3. Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis. Scientific reports
4. A novel c-Met inhibitor containing chiral pyrrolidine side chain and its application as anti-tumor agents. European journal of medicinal chemistry
5. Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy. Bioorganic chemistry
6. Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazine derivatives as potent SYK inhibitors for solid tumor therapy. Bioorganic chemistry
7. Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib. European journal of medicinal chemistry
8. Integrated computational and experimental identification of a novel ML-IAP-targeting peptide with antiproliferative activity in leukaemia cells. Journal of enzyme inhibition and medicinal chemistry

Study types

Randomized trial / meta-analysis 30 · Clinical trial 2 · Human study 190 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Quality of Life 65 · Depression 26 · Cancer Survivors 25 · Anxiety 24 · Exercise 17 · Fatigue 16

Sub-areas (papers sharing 3+ concepts)

• 37 Depression · Anxiety · Feasibility Studies
  Feasibility of an N-of-1 trial using a crossover design to evaluate music therapy in patients with breast cancer undergoing adjuvant chemotherapy: a multicentre pilot study protocol in two Italian centres (IMPACT-CASTA DIVA).Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer.
• 34 Neoplasms · Cancer Survivors · Quality of Life
  A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial.International phase IV field study to validate the European Organisation for Research and Treatment of Cancer questionnaire for assessing the health-related quality of life of cancer survivors: The EORTC QLQ-SURV100.
• 19 Exercise · Exercise Therapy · Diabetes Mellitus, Type 2
  A qualitative study of cancer survivors' exercise behaviour 4 months after a telerehabilitation program.Feasibility of a remote and home-based personalised exercise programme in cancer survivors with lymphoedema.
• 16 Multicenter Studies as Topic · Randomized Controlled Trials as Topic · Randomized Controlled Trial
  Effectiveness of Tuina Therapy for Patients With Chronic Fatigue Syndrome: Protocol for a Multicenter, Randomized, Open-Label, Assessor-Blinded, Parallel-Group Clinical Trial.Randomised comparative effectiveness trial evaluating the efficacy and safety of acupuncture-related integrative therapy combined with celecoxib for chronic pain in patients with knee osteoarthritis: protocol.
• 15 Coping Skills · Adaptation, Psychological · Glioma
  Mapping EORTC-QLQ-C30 scores to EQ-5D-5L utility values for gynecological cancer survivors in follow-up care.From diagnosis to daily realities: longitudinal phenomenological exploration of symptom trajectories in glioma survivorship.
• 10 Longitudinal Studies · Plant Oils · Oils, Volatile
  Beyond tumor response: hope and decision regret during immunotherapy for hepatocellular carcinoma.Effects of inhaled lavender essential oil on sleep quality, pain, and anxiety in ICU patients after curative hepatocellular carcinoma resection: a quasi-experimental study.

Elsewhere on this page

• Trial readout Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.
• Trial readout A comparison of the efficacy of cognitive-behavioral stress management and acceptance and commitment therapy on the quality of life and fatigue of caregivers of patients with cancer: a randomized controlled trial.

Representative papers

1. Ketamine assisted psychotherapy to reduce chronic neuropathic pain: A mixed-methods randomized pilot trial. Med (New York, N.Y.)
2. Effectiveness and psychological mechanism of group-based IMPROVE therapy for treatment seeking college students with problematic internet use in China: study protocol for a prospective, single-blind, randomised clinical trial. BMJ open
3. Effect of active noise-cancelling headphones combined with music therapy on postoperative recovery quality after general anaesthesia for ankle fracture ORIF: a study protocol for a single-centre, four-arm 2×2 factorial randomised controlled trial in China. BMJ open
4. A head-to-head comparison of health utilities and measurement properties of the EQ-5D-5L and SF-6Dv2 among people living with HIV in China. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
5. Improving Sleep and PTSD Outcomes in Service Members: A Randomized Controlled Trial Examining the Long-Term Effects of an Integrated Treatment. Behavior therapy
6. Beta Testing an mHealth Symptom Management Intervention for People With Advanced Cancer: Single-Cohort Feasibility and Acceptability Study. JMIR cancer
7. Toward personalized interventions for preventing depression in primary care: Qualitative and quantitative findings from the e-predictD pilot study. PloS one
8. Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer. Psycho-oncology

Study types

Randomized trial / meta-analysis 12 · Clinical trial 1 · Human study 200 · Animal (in vivo) 2 · In vitro / preclinical 3

Key concepts (papers in this area)

Biomarkers 72 · Risk Assessment 36 · Cardiovascular Diseases 34 · Renal Insufficiency, Chronic 23 · Diabetes Mellitus 23 · Mortality 21

Sub-areas (papers sharing 3+ concepts)

• 38 Risk Assessment · Cardiovascular Diseases · Proteomics
  Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate.Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study.
• 27 Diabetic Nephropathies · Albuminuria · Renal Insufficiency, Chronic
  Kidney function parameters in South African children living with HIV on antiretroviral therapy.Clinical Evidence of Kidney Protection Exerted by SGLT2 Inhibitors.
• 22 ROC Curve · Biomarkers · Inflammation
  Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery.The Predictive Value of The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score for One-Month Prognosis and First-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation.
• 12 Predictive Learning Models · Boosting Machine Learning Algorithms · Machine Learning
  Development and temporal validation of a machine learning-based prediction model for long-term depressive symptoms in older adults with cardiovascular disease or hypertension: A longitudinal cohort study.Machine learning-based nomogram for acute kidney injury after liver transplantation.
• 8 Kidney Transplantation · Graft Rejection · Body Mass Index
  A CVD Classification Model for Individuals With Obesity: Multi-Ethnic Validation Based on Multiple Metabolic Indicators.Antithymocyte Globulin Induction Dosed on Ideal Body Weight: Absolute Lymphocyte Count (ALC) Depletion in Kidney Transplant Recipients with and without Obesity.
• 7 Lupus Nephritis · Lupus Erythematosus, Systemic · Rituximab
  Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan.Efficacy and safety of telitacicept combined with standard of care in patients with proliferative lupus nephritis: a real-world retrospective study.

Representative papers

1. Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate. Cardiovascular diabetology
2. Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. Cardiovascular diabetology
3. Haptoglobin and Immunoglobulin A2 Predict Cardiovascular Risk in Asymptomatic Subjects: The BioImage Study. Journal of the American Heart Association
4. Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery. Journal of the American Heart Association
5. Associations of Cardiovascular-Kidney-Metabolic Syndrome With All-Cause and Cardiovascular Death and the Progression of Cardiovascular-Kidney-Metabolic Syndrome Among Hong Kong Chinese People Over 2 Decades. Journal of the American Heart Association
6. Global burdens of diabetes mellitus in adolescents from 1990 to 2023 and future trend predictions: An analysis of the Global Burden of Disease study 2023. PloS one
7. Comprehensive trends in Chronic Kidney Disease prevalence and comorbidities across eGFR and albuminuria categories: a 20-year analysis of NHANES data. Renal failure
8. Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety. European journal of clinical pharmacology

Study types

Randomized trial / meta-analysis 23 · Clinical trial 1 · Human study 131 · Animal (in vivo) 8 · In vitro / preclinical 5

Key concepts (papers in this area)

Diabetes Mellitus, Type 2 74 · Blood Glucose 51 · Obesity 49 · Diabetes Mellitus, Type 1 37 · Body Mass Index 35 · Glycated Hemoglobin 34

Sub-areas (papers sharing 3+ concepts)

• 45 Obesity · Body Mass Index · Overweight
  Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis.
• 41 Diabetes Mellitus, Type 2 · Blood Glucose · Glycated Hemoglobin
  Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT.Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality.
• 30 Hypoglycemic Agents · Dipeptidyl-Peptidase IV Inhibitors · Glucagon-Like Peptide-1 Receptor Agonists
  Effects of Pharmacological GIP Infusion on Insulin, Glucagon, and Cardiovascular Responses During Hyperglycemia in Type 2 Diabetes.Guideline on treatment intensification with injectable therapies beyond GLP-1 RA based therapies in type 2 diabetes.
• 28 Insulin Infusion Systems · Diabetes Mellitus, Type 1 · Continuous Glucose Monitoring
  Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1).Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study.

Representative papers

1. Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study. Diabetes research and clinical practice
2. U-500 regular insulin in automated insulin delivery systems for severe insulin resistance: A single-center retrospective cohort. Diabetes research and clinical practice
3. Prescribing Trajectories in Type 2 Diabetes in the United States, 2019-2024. Diabetes, obesity & metabolism
4. Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1). Diabetes research and clinical practice
5. Variability in Intravenous Insulin Infusion Management in Italian Intensive Care Units: A National Cross-Sectional Survey of Reported Nursing Practice. Nursing in critical care
6. Weight Loss-Dependent Changes in Body Composition and Bone Health in People With Obesity and Type 1 Diabetes Treated With Liraglutide, Semaglutide, or Tirzepatide. Diabetes/metabolism research and reviews
7. Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality. Diabetes research and clinical practice
8. Simplifying meal bolusing with Omnipod 5: real-world outcomes to support simplified user-initiated insulin dosing strategies in managing type 1 or type 2 diabetes. Diabetes research and clinical practice

Study types

Randomized trial / meta-analysis 26 · Clinical trial 2 · Human study 107 · Animal (in vivo) 4 · In vitro / preclinical 1

Key concepts (papers in this area)

Heart Failure 30 · Stroke 26 · Ischemic Stroke 21 · Atrial Fibrillation 19 · Myocardial Infarction 13 · Direct Oral Anticoagulants 10

Sub-areas (papers sharing 3+ concepts)

• 20 Anticoagulants · Direct Oral Anticoagulants · Factor Xa Inhibitors
  Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial.Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk.
• 19 Natriuretic Peptide, Brain · Ventricular Function, Left · Stroke Volume
  Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts.Validation of an Artificial Intelligence-Derived ECG Algorithm for Detecting Cardiac Amyloidosis in Patients With Heart Failure With Preserved Ejection Fraction: Clinical Application and Prognostic Implications.
• 19 Heart Failure · Cardiovascular Diseases · Sodium-Glucose Transporter 2 Inhibitors
  Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data - Large-Scale Epidemiological Study.Heart failure guideline-directed medical therapy in young adults with dystrophin-related cardiomyopathy: the HOPE-MD registry.
• 13 Ischemic Stroke · Functional Outcomes · Fibrinolytic Agents
  Butylphthalide combined with tenecteplase in mild disabling acute ischaemic stroke in China (BENEFIT-2): study protocol for a multicentre, randomised, double-blind, active-controlled trial.Association of time of day at stroke onset with functional outcomes after reperfusion therapy in acute ischaemic stroke: a retrospective cohort study in China.
• 9 tau Proteins · Amyloid beta-Peptides · Alzheimer Disease
  Brain-derived plasma p-tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change.Plasma phosphorylated tau217 discordance with amyloid status in an ethnically diverse mixed memory clinic cohort.
• 8 Percutaneous Coronary Intervention · Coronary Angiography · Clopidogrel
  Clopidogrel vs Aspirin According to Diabetes Mellitus: A Prespecified Analysis of the SMART-CHOICE 3 Trial.Clopidogrel Versus Dual-Antiplatelet Therapy for Long-Term Maintenance After Coronary Stenting in Ischemic and Bleeding Birisk Patients With Acute Coronary Syndromes and Diabetes: A Prespecified Subgroup Analysis of the OPT-BIRISK Trial.

Elsewhere on this page

• Trial readout Empagliflozin Promotes Natriuresis in Diabetic Patients with Cirrhotic Refractory Ascites: A Proof-of-Concept Study.

Representative papers

1. Reduced-dose direct oral anticoagulant versus antiplatelet strategies after left atrial appendage occlusion. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
2. Etiologic spectrum of direct oral anticoagulant breakthrough stroke in atrial fibrillation: The role of pseudo-failure and non-cardioembolic mechanisms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
3. Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial. BMJ open
4. Long-Term Effectiveness and Safety of Direct Oral Anticoagulants in Japanese Patients With Venous Thromboembolism - Extended Follow-up Results From the KUROSIO Study. Circulation journal : official journal of the Japanese Circulation Society
5. Clopidogrel Versus Dual-Antiplatelet Therapy for Long-Term Maintenance After Coronary Stenting in Ischemic and Bleeding Birisk Patients With Acute Coronary Syndromes and Diabetes: A Prespecified Subgroup Analysis of the OPT-BIRISK Trial. Journal of the American Heart Association
6. Early-event pathways to 6-month death or dependency after ischemic stroke: Secondary analysis of the international stroke trial. Journal of the neurological sciences
7. Effect of periprocedural antithrombotic medication on functional outcome and symptomatic intracranial hemorrhage in patients with carotid tandem lesions. BMJ open
8. A biomimetic nano-platelet as an antidote for dual antiplatelet therapy-induced bleeding. Journal of controlled release : official journal of the Controlled Release Society

Study types

Randomized trial / meta-analysis 2 · Human study 101

Key concepts (papers in this area)

Vaccination 47 · Health Knowledge, Attitudes, Practice 25 · COVID-19 18 · Health Personnel 14 · Vaccination Hesitancy 12 · HPV Vaccination 9

Sub-areas (papers sharing 3+ concepts)

• 22 Attitude of Health Personnel · Influenza Vaccines · Pregnancy
  Predictors of influenza vaccination among Iranian pregnant women based on a combined Health Belief Model and Theory of Planned behavior.Differing influenza vaccine uptake and recommendation behavior among healthcare workers in primary health centers, secondary and tertiary hospitals, and schools in a metropolis of southern China.
• 20 Papillomavirus Vaccines · Papillomavirus Infections · Human Papillomavirus Viruses
  Protect her future: Lessons learned from a school and community engagement initiative for HPV vaccine awareness in Lilongwe, Malawi.Guardians' willingness to vaccinate primary and secondary school girls against human papillomavirus and associated factors in ethnic autonomous prefectures of Qinghai Province, China: A cross-sectional study based on the Health Belief Model and Theory of Planned Behavior.
• 16 SARS-CoV-2 · COVID-19 · COVID-19 Vaccines
  Mpox Vaccine Acceptance Among Health Care Workers in Central Asia: The Role of COVID-19 Experience.Challenges in Defining Severe Influenza With Implications for Measuring and Communicating Influenza Vaccine Effects.
• 5 Digital Health · Implementation Science · Feasibility Studies
  Effects of a Digital Decision Support System on Diabetes Management in a Real-World Home Care Setting: Prospective Quasi-Experimental Feasibility and Implementation Study.Passive Digital Marker-enabled identification and engagement for Alzheimer's disease and related dementias care in primary care: the INCLUDE study protocol.

Representative papers

1. Guardians' willingness to vaccinate primary and secondary school girls against human papillomavirus and associated factors in ethnic autonomous prefectures of Qinghai Province, China: A cross-sectional study based on the Health Belief Model and Theory of Planned Behavior. Human vaccines & immunotherapeutics
2. Impact of a Culturally Tailored Educational Intervention on Human Papillomavirus Knowledge and Vaccination Intentions Among Women in Saudi Arabia: Quasi-Experimental Study. JMIR public health and surveillance
3. Parents' and caregivers' views on pediatric meningococcal disease and serogroup B vaccination. Human vaccines & immunotherapeutics
4. Protect her future: Lessons learned from a school and community engagement initiative for HPV vaccine awareness in Lilongwe, Malawi. Human vaccines & immunotherapeutics
5. Mpox Vaccine Acceptance Among Health Care Workers in Central Asia: The Role of COVID-19 Experience. Disaster medicine and public health preparedness
6. Differing influenza vaccine uptake and recommendation behavior among healthcare workers in primary health centers, secondary and tertiary hospitals, and schools in a metropolis of southern China. Expert review of vaccines
7. Nutritional knowledge, attitudes, and practices (KAP) and GLIM-defined malnutrition in hospitalized head and neck cancer patients receiving surgical treatment: A cross-sectional study in china. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
8. A Comparative Policy Analysis of HPV Vaccination Guidelines: Actors, Context, Content, and Process Across Eight Countries. Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

Study types

Randomized trial / meta-analysis 7 · Clinical trial 2 · Human study 80 · In vitro / preclinical 1

Key concepts (papers in this area)

Overall Survival 62 · Progression-Free Survival 29 · Disease-Free Survival 23 · Neoadjuvant Therapy 19 · Neoplasm Recurrence, Local 19 · Pathologic Complete Response 12

Sub-areas (papers sharing 3+ concepts)

• 23 Neoadjuvant Therapy · Pathologic Complete Response · Chemotherapy, Adjuvant
  Efficacy of adjuvant chemotherapy for triple-negative early breast cancer with tumor size ≤ 1 cm and node-negative from the National Clinical Database-Breast Cancer Registry in Japan.Contemporary therapy for small node-negative triple-negative breast cancer: a retrospective cohort study.
• 22 Progression-Free Survival · Overall Survival · Lung Neoplasms
  Validation of the lung immune prognostic index in extensive-stage small cell lung cancer: Post hoc analysis of the caspian and IMpower133 phase 3 trials.Circadian timing of first-line chemoimmunotherapy is associated with survival in extensive-stage small cell lung cancer.
• 20 Disease-Free Survival · Neoplasm Recurrence, Local · Gastrectomy
  Preoperative RDW-Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery.Recurrence detection in patients with triple-negative breast cancer following the current standard of care: a microsimulation model.
• 14 Kidney Neoplasms · Carcinoma, Renal Cell · Immunotherapy
  Prognostic Value of the Lung Immune Prognostic Index in Metastatic Renal Cell Carcinoma Treated With Second-Line Immunotherapy.Combination of baseline and first-week neutrophil-to-lymphocyte ratio predicts overall survival in advanced renal cell carcinoma treated with first-line combination immunotherapy.
• 9 Prostatic Neoplasms, Castration-Resistant · Metastatic Castration-Resistant Prostate Cancer · Radiopharmaceuticals
  Prognostic value of neutrophil-to-lymphocyte ratio in mCRPC patients treated with abiraterone, enzalutamide and docetaxel: a retrospective single-center study.18F-FDG PET/CT-based recurrence patterns and survival outcomes in esophageal carcinoma: a single center experience.

Elsewhere on this page

• Trial readout Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.

Representative papers

1. Feasibility of Lower Neck Sparing in Postoperative Radiotherapy for Parotid Gland Cancer. In vivo (Athens, Greece)
2. Prognostic Value of the Lung Immune Prognostic Index in Metastatic Renal Cell Carcinoma Treated With Second-Line Immunotherapy. International journal of urology : official journal of the Japanese Urological Association
3. Mismatch repair deficiency or microsatellite instability in locally advanced rectal cancer patients treated with total neoadjuvant therapy. European journal of cancer (Oxford, England : 1990)
4. Weight loss despite nutritional support predicts poor outcomes after postoperative chemoradiotherapy for high-risk head and neck cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
5. Contemporary therapy for small node-negative triple-negative breast cancer: a retrospective cohort study. Breast cancer research and treatment
6. Preoperative RDW-Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery. Cancer medicine
7. Crossing the milestone: landmark-based conditional survival after first-line CDK4/6 inhibitor therapy in HR+/HER2-metastatic breast cancer. Breast cancer (Tokyo, Japan)
8. Time-dependent recurrence patterns after curative resection for stage II/III colorectal cancer: An integrated analysis of four phase III randomized controlled trials (JCOG2310A-S4). European journal of cancer (Oxford, England : 1990)

Study types

Randomized trial / meta-analysis 3 · Human study 79 · In vitro / preclinical 1

Key concepts (papers in this area)

Aging 22 · Multiple Sclerosis 14 · Cognition 13 · Cognitive Dysfunction 12 · Expanded Disability Status Scale 5 · Muscle Strength 3

Sub-areas (papers sharing 3+ concepts)

• 9 Aging · Brain · Ovarian Reserve
  Reduced Paramagnetic Rim Visibility Signals Lesion Aging and Tissue Degeneration in Progressive Multiple Sclerosis: Impact on Clinical Trials.Transient Elevation and Subsequent Normalization of Brain Age Gap During the Postpartum Period.
• 8 Glial Fibrillary Acidic Protein · Neurofilament Light Chain · Plasma Biomarkers
  Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum.A multimodal model for clinically defined MCI integrating plasma biomarkers and brain microstructural features: a dual-cohort external validation study.
• 6 Cognitive Dysfunction · Blood-based biomarkers · Older Adults
  Circulating Metabolite Signatures Associated With Amyloid Positivity, Cognitive Performance and Plasma P-tau181 Levels in Cognitively Unimpaired Older Adults.Ebetsu Active Future Study (EAFS): cognitive function and physical and mental health in elderly residents of Ebetsu City, Japan - cohort profile.
• 5 Immunologic Factors · Natalizumab · Sweden
  Genetic modification of obesity-associated disability progression in multiple sclerosis.Late-Onset Neutropenia After Rituximab in Multiple Sclerosis: Incidence, Predictors, and Outcomes in a Retrospective Multicenter Cohort.

Representative papers

1. Ebetsu Active Future Study (EAFS): cognitive function and physical and mental health in elderly residents of Ebetsu City, Japan - cohort profile. BMJ open
2. The Effect of Integrated Aerobic and Cognitive Training (Activ4Brain) on Cognition and Neurophysiology in Older Adults: Protocol for a Controlled Trial. JMIR research protocols
3. Age-related changes in corneal parameters in the Turkish population: a Pentacam-based study. BMC ophthalmology
4. Effects of six weeks of guanidinoacetic acid supplementation with and without creatine monohydrate on cognitive function and markers of health in healthy adults. Journal of the International Society of Sports Nutrition
5. Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association
6. Variability in cross-modal proprioceptive judgements impairs upper-limb function across the lifespan. Journal of applied physiology (Bethesda, Md. : 1985)
7. Reduced Paramagnetic Rim Visibility Signals Lesion Aging and Tissue Degeneration in Progressive Multiple Sclerosis: Impact on Clinical Trials. Neurology(R) neuroimmunology & neuroinflammation
8. Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome. eLife

Study types

Randomized trial / meta-analysis 1 · Human study 29 · Animal (in vivo) 39 · In vitro / preclinical 3

Key concepts (papers in this area)

Tumor Microenvironment 43 · Immunotherapy 29 · PD-1 21 · CD8-Positive T-Lymphocytes 14 · CD8+ T cells 12 · Tumor-Associated Macrophages 8

Sub-areas (papers sharing 3+ concepts)

• 17 Immunotherapy · Macrophages · PD-1
  Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy.Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses.
• 13 Neoplasms · Gene Expression Regulation, Neoplastic · Tumor Microenvironment
  Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization.
• 13 Biomarkers, Tumor · T-Cell Exhaustion · Brain Neoplasms
  Intratumoral PD-1+LAG-3+CD8+ T cells are associated with improved prognosis in gastric cancer.PRKX-mediated stabilization of PD-L1 characterizes an immunosuppressive gastric cancer subtype.
• 11 Tumor microenvironment - TME · Programmed Cell Death 1 Receptor · Carcinoma, Non-Small-Cell Lung
  Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer.Epigenetic plus cytokine therapy induces stem-like CD8+ T-cell reservoirs and intratumoral immune niches to overcome anti-PD-1 resistance.

Representative papers

1. Cofilin1-driven cytoskeletal remodeling modulates pan-cancer CD8+ T cell immunotherapy responses. Cell reports. Medicine
2. Tumor-specific immunological and pathological changes in layer chickens affected with ovarian adenocarcinoma. Developmental and comparative immunology
3. Engineered bacterial outer membrane vesicle vaccine prevents T cell exhaustion for antibacterial immunotherapy. Cell reports
4. Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy. Oncoimmunology
5. Integrated Spatial Immune Phenotyping Identifies a Suppressive-infiltrated High-risk Subgroup in Esophageal Squamous Cell Carcinoma. Anticancer research
6. Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies. Cancer cell
7. Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes. The Journal of clinical investigation
8. Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer. Journal for immunotherapy of cancer

Study types

Human study 3 · Animal (in vivo) 53 · In vitro / preclinical 13

Key concepts (papers in this area)

Mesenchymal Stem Cells 25 · Exosomes 17 · Cell Differentiation 15 · Osteogenesis 10 · Fibroblasts 7 · Bioprinting 6

Sub-areas (papers sharing 3+ concepts)

• 13 Osteogenesis · Cell Differentiation · Mesenchymal Stem Cells
  3D-printed PCL/nHA/SA/COL loaded with M2 macrophage-derived exosomes alleviates the senescence of bone marrow mesenchymal stem cells.Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications.
• 9 Tendon Injuries · Muscle, Skeletal · Achilles Tendon
  Development of mechanically optimized biomimetic hybrid scaffold-stem cell constructs for functional tendon regeneration and restoration of mechanical integrity.Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model.
• 7 Hydrogels · Tissue Engineering · Bioprinting
  One-step encoding of quasi-continuous compositional and structural gradients in melt electrowritten scaffolds for osteochondral regeneration.3D bioprinting of stromal vascular fraction enriched with MXenes for enhanced intestinal regeneration.
• 6 Idiopathic Pulmonary Fibrosis · Signal Transduction · Fibroblasts
  Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling.Mannose-modified tobacco mosaic virus-mediated macrophage regulation inhibits pulmonary fibrosis progression.

Elsewhere on this page

• Key finding 177Lu-trastuzumab for HER2+ Brain Metastases

Representative papers

1. Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications. Journal of dentistry
2. Bioprinted dentin-pulp platform with decoupled mechanics promotes mineralization and vessel-like structures' formation in confined 3D microenvironments. Biofabrication
3. Development of mechanically optimized biomimetic hybrid scaffold-stem cell constructs for functional tendon regeneration and restoration of mechanical integrity. PloS one
4. Metabolomics-guided isolation of myogenic progenitor cells for improved transplantation. American journal of physiology. Cell physiology
5. Chitosan nanoparticles promote TGF-Β1 release from dentin and support stem cell attachment and differentiation in vitro. Journal of dentistry
6. Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling. Lung
7. Biomimetic recombinant humanized type III collagen peptide-RGD loaded alginate hydrogels enhance proliferation of mesenchymal-lineage cells via Integrin α5β1 activation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
8. Gelatin Methacrylate as a Mesenchymal Stem Cell Delivery Vehicle: Experimental and Semi-Quantitative Evaluation Under Metabolic Stress. Macromolecular bioscience

Study types

Randomized trial / meta-analysis 6 · Clinical trial 9 · Human study 38 · Animal (in vivo) 4

Key concepts (papers in this area)

Lung Neoplasms 36 · Carcinoma, Non-Small-Cell Lung 32 · Mutation 18 · Chemoradiotherapy 10 · Radiotherapy 6 · Osimertinib 6

Sub-areas (papers sharing 3+ concepts)

• 30 Chemoradiotherapy · Antibodies, Monoclonal, Humanized · Immunotherapy
  Chemoimmunotherapy With or Without Thoracic Radiotherapy for Elderly Patients in Advanced Non-Small Cell Lung Cancer.AdvanTIG-105: a phase I/Ib dose-expansion study of ociperlimab plus tislelizumab with or without chemotherapy in metastatic non-small cell lung cancer and extensive-stage small cell lung cancer.
• 20 ErbB Receptors · Protein Kinase Inhibitors · Mutation
  Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.Osimertinib With or Without Chemotherapy in Advanced Non-Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations: A Randomized Clinical Trial.

Representative papers

1. Afatinib Overcomes Osimertinib Resistance via Egfr V804F Mutation in a Syngeneic Egfr-Mutant Lung Cancer Mouse Model. Cancer science
2. Radiotherapy in Thoracic NUT Carcinoma: A Pooled Analysis of Long-term Survivors and Clinical Outcome Heterogeneity. Archivos de bronconeumologia
3. Central Nervous System Activity of Lazertinib in EGFR-Mutated NSCLC With Prior EGFR TKI Exposure: A Pooled Analysis of KCSG-LU20-15 and LU21-01. Thoracic cancer
4. Clinical characteristics and management of Li-Fraumeni syndrome-associated lung cancer. Lung cancer (Amsterdam, Netherlands)
5. Landscape of Chinese Lung Cancer Patients With Compound Mutations and Acquired Resistance Alterations: A Retrospective Study. International journal of cancer
6. Adding local gyro-knife radiotherapy to EGFR-TKI improves outcomes in EGFR-mutant NSCLC. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
7. Clinical Significance of EGFR Amplification in Patients with EGFR-Mutated Metastatic Non-Small Cell Lung Cancer Receiving First-line Osimertinib. Clinical cancer research : an official journal of the American Association for Cancer Research
8. Role of VEGFA/VEGFR2 signaling in predicting clinical outcomes of EGFR-TKI treatment in EGFR-mutant non-small cell lung cancer. British journal of cancer