This month in biomedical research, distilled from PubMed. Updated 2026.10.03.

Study types

Randomized trial / meta-analysis 8 · Human study 30 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Diabetes Mellitus, Type 2 26 · Hypoglycemic Agents 20 · Obesity 19 · Body Mass Index 11 · Semaglutide 10 · Glucagon-Like Peptide-1 Receptor Agonists 9

Sub-areas (papers sharing 3+ concepts)

• 14 Body Mass Index · Obesity · Cardiovascular Diseases
  A cross-regional initiative for improving type 2 diabetes mellitus care quality measurement in Spain - The Diabetes Lighthouse project.BMI trajectories and their relation to medication, comorbidities, and healthcare service use among people with type 2 diabetes mellitus.
• 10 Hypoglycemic Agents · Medication Adherence · Diabetes Mellitus, Type 2
  Durability and Safety of Imeglimin as an Add-On to DPP-4 Inhibitors in Japanese Type 2 Diabetes: The 104-Week FAMILIAR Trial.Heterogeneous treatment effects of GLP-1RA on kidney outcomes in patients with type 2 diabetes.
• 10 Semaglutide · Glucagon-Like Peptides · Tirzepatide
  Real-world treatment patterns and cost per patient achieving treatment targets among tirzepatide and semaglutide initiators in US patients with type 2 diabetes.Tirzepatide safety in EudraVigilance: descriptive and disproportionality analysis of preferred terms related to suboptimal treatment outcomes and drug-use-related issues.

Representative papers

1. A cross-regional initiative for improving type 2 diabetes mellitus care quality measurement in Spain - The Diabetes Lighthouse project. Primary care diabetes
2. Estimating the Wider Societal Impact of Semaglutide Across Multiple Indications in Canada: an Economic Evaluation. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
3. Overview of weight loss medicines and practical advice for patients. Nursing standard (Royal College of Nursing (Great Britain) : 1987)
4. Trends in utilization of glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors, and metabolic bariatric surgery in U.S. adults with diabetes and obesity. Diabetes research and clinical practice
5. BMI trajectories and their relation to medication, comorbidities, and healthcare service use among people with type 2 diabetes mellitus. Diabetes research and clinical practice
6. Effects of gestational weight gain and HbA1C on fetal growth and birthweight in women with obesity. Acta obstetricia et gynecologica Scandinavica
7. Tirzepatide safety in EudraVigilance: descriptive and disproportionality analysis of preferred terms related to suboptimal treatment outcomes and drug-use-related issues. BMJ open
8. Effects of semaglutide and empagliflozin on markers of endothelial function in persons with type 2 diabetes: A post hoc analysis of a randomized clinical trial. Journal of diabetes and its complications

Study types

Randomized trial / meta-analysis 1 · Clinical trial 1 · Human study 23 · Animal (in vivo) 9 · In vitro / preclinical 1

Key concepts (papers in this area)

Lung Neoplasms 22 · Carcinoma, Non-Small-Cell Lung 19 · Immunotherapy 14 · Immune Checkpoint Inhibitors 10 · Colorectal Neoplasms 7 · Small Cell Lung Carcinoma 5

Sub-areas (papers sharing 3+ concepts)

• 14 Protein Kinase Inhibitors · ErbB Receptors · Lung Neoplasms
  Genomic Profiling, Risk Stratification, and Post-Transformation Treatment Outcomes in Patients with Transformed Small-Cell Lung Cancer: A Multicenter Analysis.The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC).
• 13 Immunotherapy · Neoplasm Staging · Immune Checkpoint Inhibitors
  Adding immunotherapy to chemotherapy may improve survival after SCLC transformation in EGFR-mutant NSCLC: a multicenter real-world study.Clinical outcomes of KRAS G12C versus non-G12C mutant NSCLC treated with immunotherapy: a multicentre real-world study.

Representative papers

1. Genomic Profiling, Risk Stratification, and Post-Transformation Treatment Outcomes in Patients with Transformed Small-Cell Lung Cancer: A Multicenter Analysis. Lung cancer (Amsterdam, Netherlands)
2. First-line pyrotinib plus apatinib in advanced non-small cell lung cancer harboring HER2 mutations or amplification: a phase II trial. Lung cancer (Amsterdam, Netherlands)
3. Adding immunotherapy to chemotherapy may improve survival after SCLC transformation in EGFR-mutant NSCLC: a multicenter real-world study. Lung cancer (Amsterdam, Netherlands)
4. CLOCK confers EGFR-TKIs resistance in non-small cell lung cancer by transcriptionally upregulating LAMC2 expression and activating multiple kinase signaling. Archives of biochemistry and biophysics
5. FAK inhibitor and RAF/MEK clamp avutometinib enhance KRAS G12C inhibitor efficacy in preclinical models of non-small cell lung cancer. Science translational medicine
6. Single-arm, multicentre phase II trial of sintilimab plus platinum-based doublet chemotherapy followed by adaptive radiotherapy strategy for patients with unresectable stage III non-small-cell lung cancer in China: the ART-LUNG 01 study protocol. BMJ open
7. Clinical outcomes and genomic features of uncommon EGFR exon 19 deletion subtypes in osimertinib-treated non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands)
8. The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC). Lung cancer (Amsterdam, Netherlands)

Study types

Randomized trial / meta-analysis 4 · Clinical trial 1 · Human study 22 · Animal (in vivo) 3 · In vitro / preclinical 1

Key concepts (papers in this area)

Breast Neoplasms 29 · Receptors, Estrogen 11 · Erb-b2 Receptor Tyrosine Kinases 11 · Biomarkers, Tumor 10 · Sentinel Lymph Node Biopsy 5 · Mastectomy 5

Sub-areas (papers sharing 3+ concepts)

• 9 Biomarkers, Tumor · Risk Assessment · Oncotype DX
  The genomic landscape of HER2 negative metastatic breast cancer with loss of estrogen and progesterone receptors.Biomarker-based risk stratification for predicting late recurrence and benefit of extended endocrine therapy: A secondary analysis of the IDEAL trial.
• 8 Cyclin-Dependent Kinase 6 · Cyclin-Dependent Kinase 4 · Protein Kinase Inhibitors
  Avutometinib, Abemaciclib, and Fulvestrant in Patients with HR+/HER2- Metastatic Breast Cancer Previously Treated with CDK4/6 Inhibitor: A Single-Arm Phase I Trial.CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.
• 7 Trastuzumab · Antineoplastic Combined Chemotherapy Protocols · Trastuzumab deruxtecan
  Optimizing the ER Cutoff in HER2-Positive Breast Cancer: ER ≥ 50% Predicts Low pCR Rates and Resistance to Antibody-Drug Conjugates in the Neoadjuvant Setting.Efficacy and safety of T-DXd versus Other HER2-targeted therapies in second-line and later settings for HER2-positive metastatic breast cancer: A Bayesian network meta-analysis.

Elsewhere on this page

• Trial readout Giredestrant plus Everolimus in Advanced Breast Cancer.
• Trial readout Intermittent Pneumatic Compression in Patients with Postmastectomy Lymphedema: A Randomized Controlled Trial.

Representative papers

1. Exosomal miRNA Sequencing and Bioinformatics in Breast Cancer: A Case-Control Study in Baise, China. Journal of visualized experiments : JoVE
2. Optimizing the ER Cutoff in HER2-Positive Breast Cancer: ER ≥ 50% Predicts Low pCR Rates and Resistance to Antibody-Drug Conjugates in the Neoadjuvant Setting. Cancer medicine
3. Predictive Effect of the Er/Ki67 Ratio on Axillary Metastasis in Breast Cancer Patients. Clinical breast cancer
4. Selective Omission of Oncotype Dx Genomic Testing in Ultra-Low-Risk Luminal A Breast Cancer. Clinical breast cancer
5. Biomarker-based risk stratification for predicting late recurrence and benefit of extended endocrine therapy: A secondary analysis of the IDEAL trial. Breast (Edinburgh, Scotland)
6. Role of Sentinel Node Surgery in Identifying Candidates for Adjuvant CDK4/6 Inhibitors: Implications of Choosing Wisely and ASCO Omission Criteria. Annals of surgical oncology
7. Serial ctDNA Analysis for Monitoring Molecular Response and Acquired Resistance in Metastatic NSCLC and HR+/HER2-Negative Breast Cancer: A Real-World Study. Cancer medicine
8. Trastuzumab deruxtecan rechallenge in HER2-positive metastatic breast cancer: EN-SEMBLE. Breast (Edinburgh, Scotland)

Study types

Randomized trial / meta-analysis 3 · Human study 22

Key concepts (papers in this area)

Diabetes Mellitus, Type 1 17 · Blood Glucose 12 · Insulin Infusion Systems 9 · Glycemic Control 7 · Continuous Glucose Monitoring 7 · Precursor Cell Lymphoblastic Leukemia-Lymphoma 4

Sub-areas (papers sharing 3+ concepts)

• 9 Insulin · Hypoglycemic Agents · Insulin Infusion Systems
  Real-World Effectiveness and Safety of a Tubeless Automated Insulin Delivery System With an Adaptive Control Algorithm (APGO) in Children and Adolescents With Type 1 Diabetes: A Multicentre Observational Study.Postprandial Glycemic Control With Automated Insulin Delivery With Control-IQ Technology: The Impact of Meal Composition.
• 6 Blood Glucose Self-Monitoring · Blood Glucose · Biomarkers
  Long-term glycemic outcomes at 24 months after switching from FreeStyle Libre to FreeStyle Libre 2: A real-world study.Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta-Cell Function in Migrant-Background Populations.

Representative papers

1. Real-World Effectiveness and Safety of a Tubeless Automated Insulin Delivery System With an Adaptive Control Algorithm (APGO) in Children and Adolescents With Type 1 Diabetes: A Multicentre Observational Study. Diabetes, obesity & metabolism
2. Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta-Cell Function in Migrant-Background Populations. Diabetes, obesity & metabolism
3. Postprandial Glycemic Control With Automated Insulin Delivery With Control-IQ Technology: The Impact of Meal Composition. Diabetes, obesity & metabolism
4. High-Dimensional Mediation Analysis With Network Mediators: Applications to Pediatric Acute Lymphoblastic Leukemia. Statistics in medicine
5. Racial and Ethnic Disparities in Treatment Cost and Utilization in Pediatric and Young Adult Acute Lymphoblastic Leukemia. Journal of pediatric hematology/oncology
6. Glycemic and safety outcomes of the insulin-only bionic pancreas in older adults and individuals with impaired awareness of Hypoglycemia: a post hoc analysis of a randomized pivotal trial. Diabetes research and clinical practice
7. Comparison of Diluted Insulin (U10) Versus Standard (U100) Insulin in Automated Insulin Delivery Systems: Reducing Time Below Range in Young Children. Diabetes, obesity & metabolism
8. A decade of insulin pump therapy in a Belgian paediatric diabetes centre: longitudinal outcomes and evolving practices. Acta clinica Belgica

Study types

Human study 23 · In vitro / preclinical 1

Key concepts (papers in this area)

Stomach Neoplasms 6 · Neoadjuvant Therapy 6 · Nutrition Assessment 4 · Disease-Free Survival 3 · Laparoscopic gastrectomy 1 · Robotic gastrectomy 1

Representative papers

1. Robotic vs laparoscopic gastrectomy after neoadjuvant chemotherapy in overweight and obese patients with gastric cancer: a propensity score-matched analysis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
2. Immune-Adjusted Nodal Risk Classification After Neoadjuvant Immunotherapy for Resectable Head and Neck Cutaneous Squamous Cell Carcinoma. Annals of surgical oncology
3. Prior Extrapulmonary Malignancy and Outcomes After Lung Cancer Resection. Anticancer research
4. Association of Pretreatment Absolute Neutrophil Count and Prognostic Nutritional Index With Completion of Neoadjuvant Gemcitabine Plus S-1 in Resectable Pancreatic Cancer. Anticancer research
5. Impact of Resection Margin Width on Local Control and Prognostic Factors in HER2-enriched and Triple-negative Breast Cancer in the Modern Systemic Treatment Era. Anticancer research
6. Preoperative Prognostic Nutritional Index Predicts Long-term Outcomes After Curative Gastrectomy for Gastric Cancer. Anticancer research
7. Epidemiology and Quality of Care for Aboriginal and Torres Strait Islander Peoples Treated by Emergency Medical Services for Stroke in Victoria, Australia: Retrospective Analysis of Linked Data. The Medical journal of Australia
8. Adjuvant immunotherapy in resectable non-small cell lung cancer with nodal downstaging. Lung cancer (Amsterdam, Netherlands)

Study types

Randomized trial / meta-analysis 1 · Human study 5 · Animal (in vivo) 7 · In vitro / preclinical 10

Key concepts (papers in this area)

Anti-Bacterial Agents 21 · Microbial Sensitivity Tests 16 · Escherichia coli 11 · Staphylococcus aureus 10 · Biofilms 7 · Silver Nanoparticles 3

Sub-areas (papers sharing 3+ concepts)

• 11 Staphylococcus aureus · Anti-Bacterial Agents · Escherichia coli
  Green Synthesis of Silver Nanoparticles Using the Extract of Adenosma caeruleum R.Br.: Evaluation of Antibacterial, Antifungal and Antioxidant Activity.Phytochemical Composition and Antibacterial Activity of Medicinal Plants Against Bacterial Pathogens Isolated From Livestock Wound Infections.
• 9 Drug Resistance, Multiple, Bacterial · Microbial Sensitivity Tests · Klebsiella pneumoniae
  Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram-Negative Bacterial Strains.Antimicrobial and anti-biofilm activities of Vernonia amygdalina and Senna siamea leaf extracts against pathogenic bacteria.

Elsewhere on this page

• Key finding SHEc Enhances Drug Delivery in Cancer

Representative papers

1. Phytochemical Composition and Antibacterial Activity of Medicinal Plants Against Bacterial Pathogens Isolated From Livestock Wound Infections. MicrobiologyOpen
2. Adjuvant Antibacterial Effects of Mouriri Elliptica Against Clinical Multidrug Resistant Gram-Negative Bacterial Strains. MicrobiologyOpen
3. Antibacterial activity of seawater-derived Bacillus subtilis strain SC2 and its bioactive fraction. Archives of microbiology
4. Single unscreened carrier triggered ICU outbreak of a KPC-producing Klebsiella pneumoniae which acquired in vivo resistance to ceftazidime-avibactam, and cefiderocol. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
5. Astrakurkurone targets multidrug resistant Staphylococcus aureus biofilms through ROS-mediated cell membrane damage and β-lactamase inhibition. Microbial pathogenesis
6. Novel Peptide-Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking Study. Journal of peptide science : an official publication of the European Peptide Society
7. Photodynamic anti-biofilm PHEMA/Rose Bengal hydrogels enhanced by iodide: evidence for hydrogen peroxide and triiodide formation. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
8. Synthetic mimics of antimicrobial peptides based on poly(diitaconamide): synthesis, bioactivity and stability. Journal of materials chemistry. B

Study types

Randomized trial / meta-analysis 1 · Human study 20

Key concepts (papers in this area)

Sarcopenia 8 · Frailty 5 · Renal Dialysis 5 · Kidney Failure, Chronic 4 · Dementia 3 · Malnutrition 2

Sub-areas (papers sharing 3+ concepts)

• 5 Hand Strength · Muscle Strength · Diabetes Mellitus
  Muscle strength and HbA1c in geriatric patients with and without diabetes: a retrospective observational cohort study.Identifying biomarkers of accelerated ageing in cancer patients from routine clinical data.

Representative papers

1. Prevalence and Overlap of Malnutrition, Sarcopenia and Related Nutritional Syndromes in a Large Haemodialysis Population. Journal of cachexia, sarcopenia and muscle
2. Overactive Bladder Pharmacotherapy and Long-Term Care Needs, Dementia, and Frailty in Older Women. International journal of urology : official journal of the Japanese Urological Association
3. Sarcopenic Obesity as a Key Determinant of Urinary Incontinence in Older Women. Geriatrics & gerontology international
4. Sarcopenia Is Associated With Severe Treatment Toxicity and Mortality in Older Adults With Advanced Cancer: A Secondary Analysis. Journal of cachexia, sarcopenia and muscle
5. Pulmonary function and endothelial damage in patients undergoing renal replacement therapy: a cross-sectional study. Jornal brasileiro de nefrologia
6. Persistent inflammation, immunosuppression and catabolism syndrome and malnutrition in critically ill patients with sepsis: A multi-center prospective observational study. Clinical nutrition (Edinburgh, Scotland)
7. Muscle strength and HbA1c in geriatric patients with and without diabetes: a retrospective observational cohort study. Journal of endocrinological investigation
8. Identifying biomarkers of accelerated ageing in cancer patients from routine clinical data. Mechanisms of ageing and development

Study types

Human study 21

Key concepts (papers in this area)

Liver Transplantation 10 · Graft Rejection 7 · Graft Survival 5 · Survival Rate 5 · Graft Failure 3 · Deceased Donor Liver Transplantation 2

Sub-areas (papers sharing 3+ concepts)

• 5 Graft Rejection · Graft Survival · Tissue Donors
  Impact of ABO incompatibility on adult deceased donor liver transplantation outcomes: A 20-year retrospective study using the SRTR database.Five-Year Outcomes and Clinicopathological Correlations of Kidney Transplants From Deceased Donors With Diabetes.

Elsewhere on this page

• Key finding ICIs and TKIs in Cervical Cancer

Representative papers

1. Immunocomplex capture fluorescence analysis for donor selection in HLA-haploidentical peripheral blood stem cell transplantation. Transplant immunology
2. Outcomes of a Modified Portal Venovenous Bypass Technique During Liver Transplantation in High-MELD Recipients. Clinical transplantation
3. Diagnostic Performance of Donor-derived Cell-free DNA Combined With Immune Activation Markers for Detecting Acute Rejection After Liver Transplantation. Clinical transplantation
4. Five-Year Outcomes and Clinicopathological Correlations of Kidney Transplants From Deceased Donors With Diabetes. Clinical transplantation
5. Apparentness of Unseen Rejection Episodes Post Lung rLTx Is Reliably Enabled by ddcfDNA Detection. HLA
6. Impact of ABO incompatibility on adult deceased donor liver transplantation outcomes: A 20-year retrospective study using the SRTR database. Transplant immunology
7. Risk-Stratified Surveillance for Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Comparison With the RETREAT-Guided Surveillance Protocol. Clinical transplantation
8. Significance of Nontuberculous Mycobacteria Detection in Liver Transplant Recipients: A Descriptive Epidemiology. Transplantation proceedings

Study types

Randomized trial / meta-analysis 1 · Clinical trial 3 · Human study 9 · Animal (in vivo) 6

Key concepts (papers in this area)

Multiple Myeloma 10 · Antineoplastic Combined Chemotherapy Protocols 8 · Leukemia, Myeloid, Acute 5 · Venetoclax 5 · Bortezomib 3 · Antibodies, Bispecific 3

Sub-areas (papers sharing 3+ concepts)

• 6 Venetoclax · Sulfonamides · Bridged Bicyclo Compounds, Heterocyclic
  Pharmacological blockade of rho kinase enhances venetoclax responses in translational models of acute myeloid leukemia.Bortezomib Restores Venetoclax Sensitivity in Acute Myeloid Leukemia Cell Lines with Intrinsic and Acquired Resistance.
• 5 Lenalidomide · Dexamethasone · Daratumumab
  Felzartamab plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone for relapsed or refractory multiple myeloma: an open-label, parallel-controlled, randomised, phase 3 trial.Induction and extended consolidation with daratumumab, cyclophosphamide, bortezomib, lenalidomide, and dexamethasone in patients with high-risk multiple myeloma (OPTIMUM/MUKnine): 5-year follow-up of a multicentre, externally controlled, phase 2 trial.

Elsewhere on this page

• Trial readout Felzartamab plus lenalidomide-dexamethasone versus lenalidomide-dexamethasone for relapsed or refractory multiple myeloma: an open-label, parallel-controlled, randomised, phase 3 trial.

Representative papers

1. Genomic and clinical determinants of response to Azacitidine plus venetoclax in acute myeloid leukemia: Results from the HM-SCREEN-Japan 02 study. PloS one
2. αTIGIT-guided IL-15 mimetics drive potent and safe antitumor immunity by restoring tumor-infiltrating T cells. Cellular & molecular immunology
3. Refined Continuous Risk Index for Accurately Predicting Outcomes of Patients With Chronic Lymphocytic Leukemia After Limited-Duration Therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology
4. Simultaneous Population PKPD Analysis of Belantamab Mafodotin, Soluble BCMA, and Serum M-Protein in Relapsed/Refractory Multiple Myeloma. CPT: pharmacometrics & systems pharmacology
5. Pharmacological blockade of rho kinase enhances venetoclax responses in translational models of acute myeloid leukemia. Haematologica
6. Ceritinib overcomes proteasome inhibitor resistance in multiple myeloma by suppressing the protein folding response. Haematologica
7. Treatment Patterns and Clinical Outcomes Among Chinese Patients With Newly Diagnosed Multiple Myeloma: A Multicenter Retrospective Study (CHAMP-MM). Cancer medicine
8. Becotatug Vedotin Combined With Pucotenlimab in Platinum- and Immunotherapy-Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Study types

Randomized trial / meta-analysis 3 · Human study 15

Key concepts (papers in this area)

Overall Survival 16 · Progression-Free Survival 13 · Bevacizumab 5 · Carcinoma, Hepatocellular 3 · FLT3 Inhibitors 1 · Infantile Tumors 1

Sub-areas (papers sharing 3+ concepts)

• 6 Antineoplastic Combined Chemotherapy Protocols · Protein Kinase Inhibitors · Poly(ADP-ribose) Polymerase Inhibitors
  Clinical Outcomes and Prognostic Factors of ABCP Therapy in EGFR-mutated NSCLC in the Osimertinib Era.Benefits of PARP inhibitor rechallenge in patients with platinum-sensitive recurrent ovarian cancer previously treated with a PARP inhibitor: a multicenter retrospective study.

Representative papers

1. Impact of PD-1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib-Based Triple Therapy. Liver international : official journal of the International Association for the Study of the Liver
2. Prognostic factors of non-metastatic right colon adenocarcinoma: A multicentre retrospective analysis from the ATCCR database. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
3. Systemic inflammation and prognosis in patients with RAS/BRAF wild-type metastatic colorectal cancer receiving anti-EGFR therapy: A real-world cohort study. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
4. Real-world Outcomes of Trifluridine/Tipiracil With or Without Bevacizumab in Metastatic Colorectal Cancer: A Retrospective Cohort Study. Anticancer research
5. Solid Malignant Tumors in Infancy: A Single-Center Experience. Journal of pediatric hematology/oncology
6. Clinical Outcomes and Prognostic Factors of ABCP Therapy in EGFR-mutated NSCLC in the Osimertinib Era. Anticancer research
7. Impact of post-chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children's Oncology Group AREN0532, AREN0533, and AREN03B2 studies. Cancer
8. Impact of FMS-like tyrosine kinase 3 inhibitor maintenance on post-transplant outcomes in acute myeloid leukemia with FMS-like tyrosine kinase 3 mutations: a real-world German registry analysis highlighting sorafenib. Haematologica

Study types

Randomized trial / meta-analysis 2 · Clinical trial 1 · Human study 15

Key concepts (papers in this area)

HIV Infections 5 · Glomerular Filtration Rate 4 · Cholesterol, LDL 4 · Hydroxymethylglutaryl-CoA Reductase Inhibitors 4 · Dolutegravir 3 · Tenofovir Alafenamide 3

Elsewhere on this page

• Trial readout Design of VICTORION-2 Prevent: A randomized double-blind, placebo-controlled trial, assessing the impact of inclisiran on major adverse cardiovascular events in patients with established cardiovascular disease.

Representative papers

1. Expediting a UNIVERSAL first-line regimen of a dolutegravir-emtricitabine-tenofovir alafenamide fixed-dose ratio for children living with HIV older than 4 weeks: a 24-week, open-label, single-arm, phase 1-2, pharmacokinetic, safety, and antiviral activity trial. The lancet. HIV
2. Mediation Analysis of Urine Osmolality and Response to Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Assessment. Nephrology (Carlton, Vic.)
3. Plasma dolutegravir exposure testing to identify people with HIV at highest risk for dolutegravir resistance (ITREMA-2): a two-centre, prospective implementation study in South Africa. The lancet. HIV
4. The impact of switching to tenofovir alafenamide on lipid profile and renal function in chronic hepatitis B: a retrospective cohort study. European journal of gastroenterology & hepatology
5. Determinants of prevention of mother-to-child transmission (PMTCT) service utilization among adolescent girls and young women aged 15-24 years in Migori County, Kenya. African journal of reproductive health
6. Pregnancy Outcome After First-Trimester Exposure to Statins: Study Results Based on the Embryotox Cohort. Pharmacoepidemiology and drug safety
7. Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV. CPT: pharmacometrics & systems pharmacology
8. An observational study of patients receiving delayed-release budesonide (Nefecon) for immunoglobulin A nephropathy in the United States: A case series of Asian-American patients. Clinical nephrology

Study types

Human study 16

Key concepts (papers in this area)

Predictive Value of Tests 7 · Risk Assessment 5 · Apixaban 4 · Atrial Fibrillation 4 · Venous Thromboembolism 4 · Direct Oral Anticoagulants 3

Sub-areas (papers sharing 3+ concepts)

• 6 Factor Xa Inhibitors · Anticoagulants · Apixaban
  Citrated Kaolin Reaction Time on Thromboelastography 6s Identifies Bleeding-Prone Phenotypes in Older Adults with Atrial Fibrillation Receiving Direct Oral Anticoagulant Therapy.Direct oral anticoagulant use and drug-drug interactions in transplant recipients receiving calcineurin inhibitors.
• 6 Predictive Value of Tests · ROC Curve · Risk Assessment
  Risk stratification of non-acute decompensation in alcohol-related cirrhosis using the red cell distribution width-to-platelet ratio.Can Preoperative Fibrinogen-Based Ratios and Hemogram-Derived Indices Predict Early Adverse Events, 6-Month Mortality, and Perioperative Bleeding in Liver Transplant Recipients? A Retrospective Single-Center Study.

Representative papers

1. Evaluating the Impact of Therapeutic Anticoagulation Management in Head and Neck Free Tissue Transfer: A Retrospective Study of 126 Cases. Microsurgery
2. Modified HAS-BLED score for predicting delayed intracranial hemorrhage in DOAC-treated geriatric head trauma. The American journal of emergency medicine
3. Direct oral anticoagulant use and drug-drug interactions in transplant recipients receiving calcineurin inhibitors. Journal of thrombosis and haemostasis : JTH
4. Direct oral anticoagulant resumption patterns after traumatic subdural hemorrhage in atrial fibrillation: A multicenter cohort study. Clinical neurology and neurosurgery
5. Blood urea nitrogen to serum albumin ratio (BAR) predicts mortality in septic cardiomyopathy: A retrospective cohort study with external validation. Respiratory medicine
6. Individualized perampanel response and efficacy in patients with refractory epilepsy: the need for ATP-binding cassette B1 genotyping and therapeutic drug monitoring to work in tandem. Pharmacogenetics and genomics
7. Citrated Kaolin Reaction Time on Thromboelastography 6s Identifies Bleeding-Prone Phenotypes in Older Adults with Atrial Fibrillation Receiving Direct Oral Anticoagulant Therapy. Cardiovascular drugs and therapy
8. Apixaban Use Before Kidney Transplantation: Is Reversal Necessary? Pharmacotherapy