This month in biomedical research, distilled from PubMed. Updated 2026.09.28.

Study types

Randomized trial / meta-analysis 41 · Clinical trial 32 · Human study 283 · Animal (in vivo) 1 · In vitro / preclinical 2

Key concepts (papers in this area)

Overall Survival 115 · Antineoplastic Combined Chemotherapy Protocols 89 · Progression-Free Survival 69 · Biomarkers, Tumor 57 · Carcinoma, Non-Small-Cell Lung 37 · Disease-Free Survival 36

Sub-areas (papers sharing 3+ concepts)

• 54 Breast Neoplasms · Neoadjuvant Therapy · Pathologic Complete Response
  E7389-LF as a first-line chemotherapy for patients with metastatic/advanced HER2-negative breast cancer: results from the phase 1 dose-expansion part of study 114.Efficacy of adjuvant chemotherapy for triple-negative early breast cancer with tumor size ≤ 1 cm and node-negative from the National Clinical Database-Breast Cancer Registry in Japan.
• 48 Progression-Free Survival · Overall Survival · Antibodies, Monoclonal, Humanized
  The addition of bevacizumab to combination chemotherapy in patients with recurrent, persistent, or metastatic cervical cancer: Aretrospective single-arm study.Real-world safety and effectiveness of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: A multicenter Japanese cohort study.
• 37 Neoplasm Recurrence, Local · Gastrectomy · Neoplasm Recurrence
  Adjuvant oxaliplatin with S-1 (SOX) versus S-1 for stage II-III gastric cancer (CAPITAL): A randomized, open-label, phase 3 trial.Preoperative RDW-Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery.
• 34 Receptors, Chimeric Antigen · Immunotherapy, Adoptive · Venetoclax
  First-line ibrutinib plus venetoclax for nonblastoid mantle cell lymphoma in patients ≥65 years old or with TP53 mutations.Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients.
• 32 Immune Checkpoint Inhibitors · Immunotherapy · Kidney Neoplasms
  Validation of the lung immune prognostic index in extensive-stage small cell lung cancer: Post hoc analysis of the caspian and IMpower133 phase 3 trials.Circadian timing of first-line chemoimmunotherapy is associated with survival in extensive-stage small cell lung cancer.
• 28 Carcinoma, Non-Small-Cell Lung · ErbB Receptors · Lung Neoplasms
  Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.SYS6010, epidermal growth factor receptor-targeting antibody-drug conjugate for advanced non-small cell lung cancer: A phase 1 trial.

Elsewhere on this page

• Trial readout Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.
• Trial readout Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
• Trial readout Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Representative papers

1. Neoadjuvant Gemcitabine Plus S-1 for Resectable Pancreatic Ductal Adenocarcinoma: A Propensity Score-matched Study. Anticancer research
2. Feasibility of Lower Neck Sparing in Postoperative Radiotherapy for Parotid Gland Cancer. In vivo (Athens, Greece)
3. Combined Pathological Response and PEPI Score Improves Long-term Prognostic Stratification in HR-positive Breast Cancer Following Neoadjuvant Endocrine Therapy. In vivo (Athens, Greece)
4. Real-world safety and effectiveness of enfortumab vedotin plus pembrolizumab in locally advanced or metastatic urothelial carcinoma: A multicenter Japanese cohort study. Urologic oncology
5. Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer - results from the phase II DETECT IVb trial. Breast cancer research and treatment
6. Contemporary therapy for small node-negative triple-negative breast cancer: a retrospective cohort study. Breast cancer research and treatment
7. Crossing the milestone: landmark-based conditional survival after first-line CDK4/6 inhibitor therapy in HR+/HER2-metastatic breast cancer. Breast cancer (Tokyo, Japan)
8. Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients. Cancer chemotherapy and pharmacology

Study types

Randomized trial / meta-analysis 12 · Human study 201 · Animal (in vivo) 3 · In vitro / preclinical 4

Key concepts (papers in this area)

Biomarkers 71 · Machine Learning 54 · Cardiovascular Diseases 37 · Heart Failure 23 · Mortality 22 · Diabetes Mellitus 22

Sub-areas (papers sharing 3+ concepts)

• 47 Biomarkers · Inflammation · Renal Insufficiency, Chronic
  The Predictive Value of The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score for One-Month Prognosis and First-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation.Depression and Long-Term HbA1c Variability Are Additively Associated With Increased Risk of Cardiovascular-Renal Outcomes, Severe Hypoglycaemia and Mortality in Type-2 Diabetes.
• 46 Cardiovascular Diseases · Risk Assessment · Triglycerides
  Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery.Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate.
• 43 Predictive Learning Models · Machine Learning · Prediction Algorithms
  Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study.Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh.
• 28 Stroke Volume · Heart Failure · Ventricular Function, Left
  Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts.Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence.
• 11 Percutaneous Coronary Intervention · Coronary Artery Disease · Coronary Angiography
  Impact of Diabetes on Outcomes of Contemporary PCI Guided by OCT vs Angiography: The ILUMIEN IV Trial.Impact of Intravascular Imaging-Guided Drug-Eluting Stent Implantation on Cardiac Death in Patients With Diabetes.
• 7 CA-125 Antigen · Ovarian Neoplasms · Mendelian Randomization
  Development and validation of a serum peptidomic signature for early detection of asymptomatic ovarian cancer: A multi-center prospective study.Multimodal profiling of atherosclerosis: Protocol and pilot data for the AtherOMICS biobank.

Representative papers

1. Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate. Cardiovascular diabetology
2. Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. Cardiovascular diabetology
3. Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery. Journal of the American Heart Association
4. Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh. PloS one
5. The role of N-terminal probrain natriuretic peptide in predicting Kawasaki disease shock syndrome: a prospective cohort study. European journal of pediatrics
6. Longitudinal phenotyping of heart failure with preserved ejection fraction identifies early- and end-stage disease states. Open heart
7. Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study. JMIR medical informatics
8. Mitochondrial Ferritin in Subclinical Anthracycline-Induced Cardiotoxicity in Humans: A Pilot Study. Journal of cardiovascular translational research

Study types

Randomized trial / meta-analysis 22 · Clinical trial 1 · Human study 179 · Animal (in vivo) 1 · In vitro / preclinical 2

Key concepts (papers in this area)

Diabetes Mellitus, Type 2 60 · Blood Glucose 48 · Diabetes Mellitus, Type 1 36 · Insulin 33 · Glycated Hemoglobin 31 · Glycemic Control 16

Sub-areas (papers sharing 3+ concepts)

• 52 Diabetes Mellitus, Type 2 · Diabetes Mellitus · Glycated Hemoglobin
  Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT.Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality.
• 27 Insulin Infusion Systems · Insulin · Diabetes Mellitus, Type 1
  Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1).Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study.
• 19 Insulin Resistance · Glucose Tolerance Test · Diabetes, Gestational
  Associations of the bioimpedance-derived phase angle with early and advanced stages of dysglycemia: Cross-sectional findings from a large population-based study.Serum FAM19A5 in newly diagnosed type 2 diabetes mellitus and its association with metabolic and inflammatory parameters: A case-control study.
• 17 Vaccination · Vaccine Uptake · Influenza, Human
  A Multimethod Evaluation to Assess Feasibility, Acceptability, and Preliminary Efficacy of HPVVaxFacts, a Tailored Mobile Web App, for Parents With Unvaccinated Children: Pilot 2-Arm Randomized Controlled Trial.Feasibility of an N-of-1 trial using a crossover design to evaluate music therapy in patients with breast cancer undergoing adjuvant chemotherapy: a multicentre pilot study protocol in two Italian centres (IMPACT-CASTA DIVA).
• 16 SARS-CoV-2 · COVID-19 · COVID-19 Vaccines
  Incorporating public values into public health communications: Effects of value affirmations on intentions to vaccinate and trust in the U.S.Sociodemographic and Lifestyle Factors Associated With COVID-19 Vaccine Uptake in a Mixed Urban-Rural Population in Eastern Poland.
• 14 Digital Health · Artificial Intelligence · Telemedicine
  User Engagement and Feature Preferences in an AI-Powered mHealth Intervention for Diabetes Prevention: Secondary Analysis of a Randomized Controlled Trial.Facilitators and barriers to implementing a digital health-supported, community pharmacy-based prediabetes management program (PRIME program) in Malaysia: a qualitative study of participants' and pharmacists' perspectives.

Representative papers

1. Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study. Diabetes research and clinical practice
2. U-500 regular insulin in automated insulin delivery systems for severe insulin resistance: A single-center retrospective cohort. Diabetes research and clinical practice
3. Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1). Diabetes research and clinical practice
4. Simplifying meal bolusing with Omnipod 5: real-world outcomes to support simplified user-initiated insulin dosing strategies in managing type 1 or type 2 diabetes. Diabetes research and clinical practice
5. The Digital Diabetes Patient Reminder Tool for Adults With Type 2 Diabetes: Protocol for a Proof-of-Concept Randomized Controlled Trial. JMIR research protocols
6. Variability in Intravenous Insulin Infusion Management in Italian Intensive Care Units: A National Cross-Sectional Survey of Reported Nursing Practice. Nursing in critical care
7. Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality. Diabetes research and clinical practice
8. A Multimethod Evaluation to Assess Feasibility, Acceptability, and Preliminary Efficacy of HPVVaxFacts, a Tailored Mobile Web App, for Parents With Unvaccinated Children: Pilot 2-Arm Randomized Controlled Trial. JMIR cancer

Study types

Randomized trial / meta-analysis 1 · Human study 16 · Animal (in vivo) 87 · In vitro / preclinical 82

Key concepts (papers in this area)

Drug Liberation 66 · Drug Delivery Systems 60 · Drug Carriers 54 · Nanoparticles 52 · Particle Size 52 · Liposomes 25

Sub-areas (papers sharing 3+ concepts)

• 51 Drug Carriers · Hydrogen-Ion Concentration · Chitosan
  pH-Responsive Chitosan-Coated Spanlastic Nanovesicles for Enhanced Lung-Targeted Delivery of Brilliant Blue G in Acute Lung Injury.A charge-reversible hyaluronic acid prodrug nanoplatform for synergistically enhanced tumor-targeted doxorubicin delivery.
• 48 Chemistry, Pharmaceutical · Bulk Drugs · Tablets
  A structure dosage form approach for solubility and dissolution rate enhancement.Direct Powder Extrusion of Atorvastatin 3D-Printed Tablets for Immediate-Release: Solid-State Characterization and Dissolution Performance.
• 41 Liposomes · Lipids · Nanoparticles
  Formulation, Optimization and Characterization of Acetazolamide-Loaded Solid Lipid Nanoparticles for Glaucoma Treatment: In-Vitro and In-Vivo Study.Dual-drug-loaded lipid-based formulation for colon cancer therapeutics: in vitro optimization and characterization.
• 21 Skin Absorption · Skin · Administration, Cutaneous
  Topical PEGylated azelaic acid nanohybrids: A lipid-polymer hydrogel system for sustained dermal delivery in rosacea management.Clobetasol-loaded core-active lipid nanoparticles: an enhanced therapy for inflammatory skin conditions.

Elsewhere on this page

• Key finding Intranasal Nanoparticles Reduce Glioblastoma Volume

Representative papers

1. Real-Time Monitoring of Tablet API Concentration and Bioavailability via Dissolution Kinetics in Simulated Stomach Fluid by T-Ray Transmission Technique. AAPS PharmSciTech
2. Novel Hybrid Polymer-Lipid-Based Formulations for Enhanced Dissolution Rates of Poorly Water-Soluble Drugs: A Quality by Design (QbD) Approach via Hot Melt Extrusion. AAPS PharmSciTech
3. Impact of mixing method on amorphous solid dispersions fabricated via vacuum compression molding: dissolution and degree of fusion. International journal of pharmaceutics
4. Low-temperature FDM 3D printing of immediate-release glipizide tablets: formulation optimization, solid-state characterization, and dose customization. International journal of pharmaceutics
5. Scalable generation of droplet-templated amorphous solid dispersions using continuous antisolvent extraction. International journal of pharmaceutics
6. Single-Step Solvent Evaporation Via Spray-Drying for the Production of Ph-Sensitive Polymeric Nanospheres for Dermatological Applications. AAPS PharmSciTech
7. A structure dosage form approach for solubility and dissolution rate enhancement. International journal of pharmaceutics
8. Preparation and characterization of pre-nanoemulsions encapsulating multiple oil-soluble active substances. Drug development and industrial pharmacy

Study types

Human study 19 · Animal (in vivo) 90 · In vitro / preclinical 74

Key concepts (papers in this area)

Antineoplastic Agents 129 · Structure-Activity Relationship 119 · Cell Proliferation 117 · Molecular Structure 104 · Dose-Response Relationship, Drug 102 · Apoptosis 85

Sub-areas (papers sharing 3+ concepts)

• 66 Apoptosis · Antineoplastic Agents · Cell Movement
  Biphenyl sulfonylurea Analogs as novel antiangiogenic agents: A repositioning and molecular modelling strategy.Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.
• 59 Dose-Response Relationship, Drug · Molecular Structure · Structure-Activity Relationship
  Synthesis, in vitro and in silico studies of transition metal complexes of chrysin with potent anticancer activity via GSK3β phosphorylation, modulation of p38 MAPK pathway and HDAC8 inhibition.Discovery of new thiazolyl hydrazone derivatives as anti-breast cancer agents: Synthesis, biological evaluation and in silico studies.
• 52 Drug Design · Molecular Docking Simulation · Structure-Activity Relationship
  Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies.New N-(isoxazol-3-yl)-4-(1,3,4-thiadiazol-3(2H)-yl)benzenesulfonamide derivatives as potent Aurora kinases inhibitors: Design, synthesis and anti-proliferative activity.

Representative papers

1. Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies. Bioorganic chemistry
2. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry
3. Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis. Scientific reports
4. Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazine derivatives as potent SYK inhibitors for solid tumor therapy. Bioorganic chemistry
5. A novel c-Met inhibitor containing chiral pyrrolidine side chain and its application as anti-tumor agents. European journal of medicinal chemistry
6. Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib. European journal of medicinal chemistry
7. Rational design and synthesis of pyrazole-based sulfonamides as dual carbonic anhydrase and PRAK-targeting anticancer agents. Bioorganic chemistry
8. New N-(isoxazol-3-yl)-4-(1,3,4-thiadiazol-3(2H)-yl)benzenesulfonamide derivatives as potent Aurora kinases inhibitors: Design, synthesis and anti-proliferative activity. Bioorganic chemistry

Study types

Clinical trial 3 · Human study 38 · Animal (in vivo) 130 · In vitro / preclinical 12

Key concepts (papers in this area)

Immunotherapy 74 · Tumor Microenvironment 68 · T-Lymphocytes 44 · Immune Checkpoint Inhibitors 31 · CD8-Positive T-Lymphocytes 27 · Melanoma 15

Sub-areas (papers sharing 3+ concepts)

• 44 Neoplasms · Immunotherapy · Nanoparticles
  Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization.
• 36 Immunotherapy, Adoptive · Receptors, Chimeric Antigen · CAR T cells
  CCL19-armed oncolytic adenovirus synergizes with CCR7-expressing CAR-T cells to suppress ovarian tumor growth.First CAR T-Cell Therapy Approved for Solid Tumors.
• 29 Immune Checkpoint Inhibitors · Programmed Cell Death 1 Receptor · B7-H1 Antigen
  Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer.Epigenetic plus cytokine therapy induces stem-like CD8+ T-cell reservoirs and intratumoral immune niches to overcome anti-PD-1 resistance.
• 28 Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Transcriptome
  Unveiling the immune microenvironment in sinonasal intestinal type adenocarcinoma: new arguments for immunotherapy.The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression.
• 22 cGAS-STING Signaling Pathway · STING Protein · Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
  A TIGIT nanotrapping-guided STING-activatable immunometabolic strategy overcomes innate immune silence and T cell exhaustion in breast cancer.Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation.

Representative papers

1. Scalable generation of hematopoietic stem cell-engineered off-the-shelf mono-specific cytotoxic T cells targeting solid tumors. Cell reports. Medicine
2. Azidothymidine potentiates the immunomodulatory function of interferon-α in adult T cell leukemia/lymphoma. Molecular therapy : the journal of the American Society of Gene Therapy
3. Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies. Cancer cell
4. Modular mRNA cocktail enables synergistic activation of antigen-specific T cells for cancer immunotherapy. Oncoimmunology
5. Efficacy and mechanism of topical Chinese herbal formulation JieZe-1 on female lower genital tract co-infection with HSV-2 and Candida albicans via upregulating the cGAS/STING/IFN-I pathway. Journal of ethnopharmacology
6. NKG2A-HLA-E axis contributes to an immunosuppressive checkpoint network in hepatocellular carcinoma. Journal for immunotherapy of cancer
7. Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia. Oncoimmunology
8. Engineered bacterial outer membrane vesicle vaccine prevents T cell exhaustion for antibacterial immunotherapy. Cell reports

Study types

Randomized trial / meta-analysis 9 · Clinical trial 7 · Human study 137

Key concepts (papers in this area)

Hematopoietic Stem Cell Transplantation 18 · Japan 10 · Transplantation, Homologous 8 · Emergency Service, Hospital 8 · Critical Illness 5 · Pulmonary Nodule 3

Sub-areas (papers sharing 3+ concepts)

• 5 Pulmonary Nodule · Multiple Pulmonary Nodules · Tomography, X-Ray Computed
  CT-guided Preoperative Localization of Impalpable Pulmonary Nodules: Comparison Between Two Devices.Real-Time AI-Augmented Fluoroscopic Navigation for Intraoperative Pulmonary Nodule Localization: Prospective Observational Pilot Study.
• 5 Parents · Neoplasms · Paediatric Oncology
  A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial.Children's participation in assent to paediatric oncology research: experiences of children, siblings and parents.

Representative papers

1. Coxsackievirus B Infections Are Associated With the Risk of Islet Autoimmunity in Children With Strong Genetic Susceptibility to Type 1 Diabetes-Results From the TRIGR Divia Study. Diabetes/metabolism research and reviews
2. Children's participation in assent to paediatric oncology research: experiences of children, siblings and parents. Trials
3. CT-guided Preoperative Localization of Impalpable Pulmonary Nodules: Comparison Between Two Devices. In vivo (Athens, Greece)
4. The long-term follow-up outcomes and transition rates across seven representative pediatric congenital surgical conditions: disease severity drives follow-up retention. Pediatric surgery international
5. Hematopoietic Recovery and Safety Following Early Romiplostim Administration After Pediatric HSCT: A Prospective Randomized Pilot Study. Pediatric blood & cancer
6. Efficacy and safety of multimodality therapy stratified by resection rate and molecular markers in children and adolescents with ependymoma: JCCG EPN23 protocol. Japanese journal of clinical oncology
7. Perioperative outcomes and risk stratification following pediatric arteriovenous malformation resection: an ACS NSQIP-P database analysis. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
8. Intraoperative MRI in pediatric brain tumor surgery: Optimizing surgical decision-making and extent of resection. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Study types

Human study 11 · Animal (in vivo) 113 · In vitro / preclinical 5

Key concepts (papers in this area)

Oxidative Stress 39 · Neuroinflammatory Diseases 39 · Alzheimer Disease 26 · Microglia 24 · Ferroptosis 21 · Hippocampus 21

Sub-areas (papers sharing 3+ concepts)

• 24 Ferroptosis · GPX4 · ACSL4
  Acteoside alleviates high glucose-induced ROS accumulation and ferroptosis in ARPE-19 cells by activating the NRF2 signaling pathway.MCL inhibits macrophage ferroptosis through the NRF2/HO-1/GPX4 axis to attenuate carotid atherosclerotic plaque formation.
• 23 Inflammasomes · Anticonvulsants · NLR Family, Pyrin Domain-Containing 3 Protein
  Gastrodia elata Blume and Acorus tatarinowii Schott mixtures alleviate pentylenetetrazol-induced seizures in mice: association with NLRP3 inflammasome signaling changes.Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2/NLRP3 inflammasome pathway.
• 21 Alzheimer Disease · Amyloid beta-Peptides · tau Proteins
  Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation.LPI alleviates Alzheimer's disease pathology via the GPR55 receptor.
• 16 Cognitive Dysfunction · Hippocampus · Maze Learning
  Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation.SIRT1 Activation Ameliorates Neuroinflammation and Cognitive Impairment in a Murine SAE Model and is Associated with the Nrf2/GPX4 Pathway.
• 13 Structure-Activity Relationship · Molecular Structure · Dose-Response Relationship, Drug
  Design, synthesis, and evaluation of febuxostat derivatives bearing 1,2,3-triazole: potent inhibitors of microglia-mediated neuroinflammation and oxidative stress via Nrf2-HO-1 activation.Sulfonamide-flavonoid analogue SG16 shows promise as a novel anti-inflammatory agent for ischemic stroke treatment.
• 11 Plant Extracts · Caenorhabditis elegans Proteins · Caenorhabditis elegans
  Neuroprotective Effects of Cistanoside A against Cadmium-induced Neurotoxicity via Keap1/Nrf2/NF-kB Signaling: In Vivo and In Silico approaches.Molecular Neuroprotective Responses to Achyrocline satureioides Extract in Caenorhabditis elegans: Modulation of Conserved FOXO/NRF2 Pathways and Resistance to Neurotoxic Insults.

Representative papers

1. Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation. Molecular neurobiology
2. Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2/NLRP3 inflammasome pathway. International immunopharmacology
3. Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation. Molecular biology reports
4. Neuroprotective and cognitive-enhancing effects of γ-Oryzanol in bile duct ligation-induced hepatic encephalopathy in rats. Metabolic brain disease
5. High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence. Experimental brain research
6. Integrative transcriptomic and single-cell analyses identify CD74 as a candidate regulator of ferroptosis in renal tubular cells during nephrolithiasis. Renal failure
7. A Keap1-Nrf2 protein-protein interaction inhibitor 4-95 ameliorates cognitive dysfunction by suppressing neuronal ferroptosis. Bioorganic chemistry
8. Molecular Neuroprotective Responses to Achyrocline satureioides Extract in Caenorhabditis elegans: Modulation of Conserved FOXO/NRF2 Pathways and Resistance to Neurotoxic Insults. Molecular neurobiology

Study types

Randomized trial / meta-analysis 8 · Human study 118 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Neoplasms 51 · Quality of Life 33 · Cancer Survivors 20 · Patient-Centered Care 17 · Palliative Care 16 · Caregivers 9

Sub-areas (papers sharing 3+ concepts)

• 18 Quality of Life · Psychometrics · Cancer Survivors
  International phase IV field study to validate the European Organisation for Research and Treatment of Cancer questionnaire for assessing the health-related quality of life of cancer survivors: The EORTC QLQ-SURV100.Perception of fall risk among cancer survivors receiving Radiotherapy/Chemotherapy in China: A latent profile analysis.
• 13 Interviews as Topic · Palliative Care · Neoplasms
  Spiritual wellbeing in advanced cancer patients receiving palliative care in a tertiary cancer centre in northern Kerala, India: a qualitative study.Experiences of healthcare encounters among patients using complementary and alternative medicine alongside oncology or palliative care: a qualitative interview study in Sweden.
• 11 Exercise · Glioma · Fatigue
  Exploring the feasibility of exercise training during (neo)adjuvant chemotherapy in women with early-stage breast cancer: a pilot study examining immune and metabolic outcomes.From diagnosis to daily realities: longitudinal phenomenological exploration of symptom trajectories in glioma survivorship.
• 8 Communication Barriers · Medical Interpreting · Germany
  Evaluating an innovative support programme for older long-term cancer survivors (IMPULS-A): protocol for a randomised controlled trial.Exploring young adult cancer survivors' perspectives on generative AI chatbots for symptom support.
• 6 Delphi Technique · Consensus · Neoplasm Recurrence, Local
  PRiSM project: e-Delphi study on the role of specialist palliative care services in the care of people with stable locally advanced or metastatic cancer.Operationalizing fear of cancer recurrence care: a modified Delphi study establishing a consensus-based clinical pathway for Danish cancer survivors.
• 5 Existentialism · Psychological Distress · Stress, Psychological
  Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer.Meaning-centered psychotherapy for existential distress in advanced cancer: A culturally informed case report from Vietnam.

Elsewhere on this page

• Trial readout Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.

Representative papers

1. A conceptual model of cancer care and lived experiences in adolescents and young adults with cancer: results from the multi-national European STRONG AYA project. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
2. A head-to-head comparison of health utilities and measurement properties of the EQ-5D-5L and SF-6Dv2 among people living with HIV in China. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
3. Prescriber Practices and Barriers to Providing Prescription Medication Instructions for Patients With a Non-English Language Preference. Annals of family medicine
4. Beyond Caregiving: Recovery and Growth Among Primary Caregivers Following the Loss of a Family Member Living With Dementia. International journal of geriatric psychiatry
5. Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer. Psycho-oncology
6. Patient Experiences With a Symptom Monitoring and Self-Referral Program for Specialty Palliative Care After Lung Cancer Diagnosis: Qualitative Study. JMIR formative research
7. What makes support groups effective and sustainable? an exploratory qualitative study of people living with HIV in the ICON-3 practice-based research network, Nigeria. BMJ open
8. A qualitative exploration of information access and provision for cancer survivors experiencing chronic bowel symptoms after pelvic radiotherapy: informing a framework to guide improvements to information provision. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Study types

Randomized trial / meta-analysis 1 · Human study 38 · Animal (in vivo) 28 · In vitro / preclinical 35

Key concepts (papers in this area)

Limit of Detection 56 · Biosensing Techniques 43 · Metal Nanoparticles 36 · Electrochemical Techniques 26 · Gold Nanoparticles 17 · CRISPR/Cas12a 13

Sub-areas (papers sharing 3+ concepts)

• 27 Gold · Gold Nanoparticles · Metal Nanoparticles
  Aptakiss-guided CRISPR/Cas13a signal amplification for ultrasensitive FEN1 detection using CsPbBr3@PDA@AuNPs-based electrochemiluminescence platform.Gold-graphene based nanofiber biosensor for selective electrochemical identification of CD105-positive canine mesenchymal stem cells.
• 25 CRISPR-Cas Systems · CRISPR/Cas12a · Biosensing Techniques
  An electrochemiluminescence biosensor for sulfadimethoxine detection based on enzymatic DNA walker-activated CRISPR/Cas12a cascade for signal enhancement.Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage.
• 18 Fluorescent Dyes · Fluorescent Chemosensor Compounds · Spectrometry, Fluorescence
  Molecular-level biomimetic integration of phosphorus-doped graphene quantum dots with silver nanoparticles for highly stable and active nanozymes: Application in ultrasensitive ascorbic acid detection.A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles.
• 10 Silver Nanoparticles · Silver · Plant Extracts
  A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone.Phytochemical profiling-guided green synthesis and characterisation of silver nanoparticles using Catunaregam spinosa for biological applications.

Representative papers

1. Sustainable Synthesis of N, S-Enriched Carbon Sensor from Euphorbia royleana Latex for Low-Cost Fluorescence Based Detection of Arsenic Ions. Bulletin of environmental contamination and toxicology
2. Interfacial tripedal DNA walking coupled with oxygen-depletion/ECL-RET dual quenching for femtomolar detection of Tobacco Mosaic Virus RNA in plant extracts. Mikrochimica acta
3. A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles. Analytica chimica acta
4. ATP-triggered release of methylene blue for amplified photoelectrochemical bioanalysis: Enabling a split-type immunosensing platform for the detection of CA15-3. Biosensors & bioelectronics
5. A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone. Mikrochimica acta
6. A Dual-Mode Fluorescent and Colorimetric Biosensor Based on AuNPs@RCA Nanogel-Integrated Multipedal DNA Walker for Ultrasensitive miRNA Detection. ACS applied materials & interfaces
7. Machine learning-assisted smartphone fluorescence sensing for ultrasensitive and point-of-care testing of acid phosphatase. Analytica chimica acta
8. A novel fluorescent sensor based on CdTe quantum dots and DTAB-modified Au nanoparticles through aggregation-induced fluorescence recovery for the detection of l-lysine. Journal of the science of food and agriculture

Study types

Randomized trial / meta-analysis 20 · Clinical trial 2 · Human study 77

Key concepts (papers in this area)

Research Design 21 · Randomized Controlled Trials as Topic 19 · Ischemic Stroke 18 · Stroke 16 · Direct Oral Anticoagulants 8 · Intensive Care Units 5

Sub-areas (papers sharing 3+ concepts)

• 17 Multicenter Studies as Topic · Randomized Controlled Trials as Topic · Quality of Life
  Butylphthalide combined with tenecteplase in mild disabling acute ischaemic stroke in China (BENEFIT-2): study protocol for a multicentre, randomised, double-blind, active-controlled trial.Randomised comparative effectiveness trial evaluating the efficacy and safety of acupuncture-related integrative therapy combined with celecoxib for chronic pain in patients with knee osteoarthritis: protocol.
• 11 Direct Oral Anticoagulants · Factor Xa Inhibitors · Atrial Fibrillation
  Timing to restart direct oral anticoagulants after traumatic intracranial haemorrhage (RESTART tICrH): study protocol for a randomised controlled multicentre trial.Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial.
• 11 Ischemic Stroke · Brain Ischemia · Brain
  Association of time of day at stroke onset with functional outcomes after reperfusion therapy in acute ischaemic stroke: a retrospective cohort study in China.Early-event pathways to 6-month death or dependency after ischemic stroke: Secondary analysis of the international stroke trial.
• 9 Systematic Reviews as Topic · Colorectal Surgery · Meta-Analysis as Topic
  Surgical safety of preoperative or perioperative immune checkpoint inhibitors in colorectal cancer surgery: protocol for a systematic review and meta-analysis focusing on anastomotic leakage.Health technology assessment of robotic surgery for rectal cancer in China: protocol for a nationally multicentre prospective cohort study.
• 6 Respiration, Artificial · Hospital Mortality · Wound Healing
  Proton pump inhibitors in invasively ventilated patients with SARS-CoV-2: a substudy of the re-evaluating the inhibition of stress erosions trial.Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock.

Representative papers

1. Butylphthalide combined with tenecteplase in mild disabling acute ischaemic stroke in China (BENEFIT-2): study protocol for a multicentre, randomised, double-blind, active-controlled trial. BMJ open
2. Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial. BMJ open
3. Etiologic spectrum of direct oral anticoagulant breakthrough stroke in atrial fibrillation: The role of pseudo-failure and non-cardioembolic mechanisms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
4. Clinical safety and preliminary efficacy of allogeneic human induced pluripotent stem cell-derived exosomes in patients with acute ischaemic stroke: protocol of a phase I/II clinical trial in China. BMJ open
5. Effect of periprocedural antithrombotic medication on functional outcome and symptomatic intracranial hemorrhage in patients with carotid tandem lesions. BMJ open
6. API-CAT investigators' decisions on anticoagulation following extended treatment for cancer-associated thrombosis. European heart journal. Cardiovascular pharmacotherapy
7. Apomorphine and psilocybin to improve recovery from coma in the intensive care unit: protocol for a prospective, open-label, dose-escalation study. BMJ open
8. Characteristics and Reported Practices of ICUs Participating in the Sedation, Analgesia and Delirium Management International Study: Variability in Site-Level Management of Mechanically Ventilated Patients. Critical care explorations

Study types

Human study 9 · Animal (in vivo) 67 · In vitro / preclinical 22

Key concepts (papers in this area)

Hydrogels 59 · Wound Healing 26 · Biocompatible Materials 20 · Angiogenesis 13 · Alginates 11 · Vascular Endothelial Growth Factor A 7

Sub-areas (papers sharing 3+ concepts)

• 20 Wound Healing · Anti-Bacterial Agents · Staphylococcus aureus
  A multi-functional microneedle patch loaded with mupirocin and L-arginine nanoparticles for enhancing antibacterial activity, anti-inflammation and diabetic wound healing.Photothermal and immunomodulatory chitosan composite hydrogel remodels the pathological microenvironment to accelerate infected diabetic wound healing.
• 19 Tissue Scaffolds · Bone Regeneration · Methacrylates
  Photothermal-responsive dexmedetomidine-loaded MPDA-GelMA hydrogel promotes bone regeneration.Electroconductive and biodegradable scaffold based on alginate/polyaniline hydrogel loaded with green synthesized magnesium oxide nanoparticles for bone regeneration.
• 18 Particle Size · Hexuronic Acids · Biocompatible Materials
  Engineering injectable alginate hydrogels for mesenchymal stem cell delivery: comparative evaluation of ionic crosslinking strategies and earlyin vitrooutcomes.Nanostructured Hydrogel Surface Functionalization Controls C2C12 Myoblast Adhesion and Differentiation.
• 10 Neovascularization, Physiologic · Angiogenesis · TNF-α
  Manganese Dioxide Nanozyme-Constituted Composite Hydrogel to Scavenge Reactive Oxygen Species for Scarless Wound Healing.A bilayer skin-mimicking 3D-printed/electrospun wound dressing incorporating deferoxamine and propolis for angiogenesis-associated wound healing: an in vitro, in ovo, and in vivo evaluation.
• 8 Wearable Electronic Devices · Compressive Strength · Tensile Strength
  DNA-templated synthesis of hydrogel with anchored AgNPs via C-Ag+-C coordination and in situ reduction for conductive and antibacterial joint motion monitoring.High-performance lignin-based hydrogel strain sensors for human motion monitoring.
• 8 Antioxidants · Glycyrrhizic Acid · Oxidative Stress
  An injectable thiolated alginate/oxidized dextran hydrogel with curcumin-copper nanoparticles for corneal neovascularization after alkali burn.Reactive oxygen species-scavenging hydrogels loaded with tempol exert anti-oxidative effects in spinal cord injury rat models.

Representative papers

1. Evaluation of the physical and radiological properties of different Fricke gel formulations as water-equivalent materials and biological tissues. Biomedical physics & engineering express
2. Engineering injectable alginate hydrogels for mesenchymal stem cell delivery: comparative evaluation of ionic crosslinking strategies and earlyin vitrooutcomes. Biomedical materials (Bristol, England)
3. Bioactive Ion-Doped Monetite/Chitosan Thermosensitive Hydrogels with Dual Osteogenic and Pro-Angiogenic Stimuli for Bone Regeneration. ACS biomaterials science & engineering
4. One-step calcium crosslinking of chitosan/alginate/pectin/bioactive glass scaffolds with synergistic osteogenic-angiogenic activity for bone regeneration. Biomedical materials (Bristol, England)
5. Biomechanical evaluation of a poly(vinyl alcohol) hydrogel testicular prosthesis for tissue-mimicking soft-tissue replacement. Medical engineering & physics
6. Mechanically Matched PGT Hydrogel Enables Functional Bladder Augmentation and Reconstruction without Fibrosis. ACS biomaterials science & engineering
7. Single-Helical Dopamine-g-Curdlan Hydrogels Showing High Adhesiveness and Injectability. ACS applied bio materials
8. A self-crosslinking powder based on carboxymethyl chitosan and guar gum with free radical scavenging for rapid hemostasis and promotion of wound healing. Carbohydrate polymers

Study types

Randomized trial / meta-analysis 1 · Human study 16 · Animal (in vivo) 35 · In vitro / preclinical 32

Key concepts (papers in this area)

Anti-Bacterial Agents 69 · Microbial Sensitivity Tests 57 · Escherichia coli 19 · Klebsiella pneumoniae 17 · Staphylococcus aureus 13 · Acinetobacter baumannii 10

Sub-areas (papers sharing 3+ concepts)

• 29 Structure-Activity Relationship · Molecular Structure · Dose-Response Relationship, Drug
  Design and synthesis of novel baicalein-isoxazoles based scaffolds and their anti-microbial potential: in vitro and in silico evaluation.Design, synthesis and antibacterial evaluation of novel unsaturated butenolide-fatty amine hybrids against multidrug-resistant pathogens.
• 26 beta-Lactamases · Klebsiella pneumoniae · Bacterial Proteins
  Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy.Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype.
• 21 Anti-Bacterial Agents · Biofilms · Plant Extracts
  Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug-Resistant Bacteria: Preliminary Antibiotic-Interaction Screening and Exploratory Molecular Docking.Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration.

Representative papers

1. Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype. Antimicrobial agents and chemotherapy
2. Chelate-conjugated β-lactams resensitize metallo-β-lactamase IMP-1-producing gram-negative bacteria against carbapenem antibiotics. Microbiology spectrum
3. Extensively drug-resistant ESBL-producing enterobacterales and coexisting antimicrobial resistance genes are associated with mortality in critically ill patients with cancer. Scientific reports
4. Phenotypic and molecular detection of efflux pump and expression profiling genes in Klebsiella pneumoniae exposed to ciprofloxacin and amoxicillin/clavulanic acid. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
5. Essential role of the leucine-293 for the AmpC β-lactamase in the resistance to cefepime, cefiderocol, and new β-lactams/β-lactamase inhibitor combinations in Enterobacter hormaechei. International journal of antimicrobial agents
6. Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy. Microbiology spectrum
7. Antimicrobial activity of aztreonam/avibactam and molecular characterization of Enterobacterales not susceptible to ceftazidime/avibactam and/or meropenem/vaborbactam from US medical centres (2016-2024). The Journal of antimicrobial chemotherapy
8. Deciphering the Role of the Nonactive Site Ancillary Residues in Maintaining the Activity and Substrate Specificity of the OXA-232 β-Lactamase. ACS infectious diseases

Study types

Clinical trial 1 · Human study 2 · Animal (in vivo) 64 · In vitro / preclinical 11

Key concepts (papers in this area)

Mesenchymal Stem Cells 25 · Exosomes 22 · Cell Differentiation 17 · Cellular Senescence 12 · Osteogenesis 11 · T-Lymphocytes, Regulatory 7

Sub-areas (papers sharing 3+ concepts)

• 11 Mesenchymal Stem Cell Transplantation · Mesenchymal Stem Cells · Cytokines
  Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model.Mesenchymal stem cells from Cerdocyon thous: in vitro characterization and therapeutic potential.
• 11 MicroRNAs · Gene Expression Regulation, Neoplastic · Cell Proliferation
  Keratinocyte-derived exosomes serve as an active messenger platform for LINC01605 to amplify TGF-β1-induced fibroblasts activation.Exosomal miR-22-3p targets p53 to regulate endometrial epithelial cell function in the pathogenesis of endometriosis.
• 10 Mesenchymal Stem Cells · Umbilical Cord · Osteogenesis
  3D-printed PCL/nHA/SA/COL loaded with M2 macrophage-derived exosomes alleviates the senescence of bone marrow mesenchymal stem cells.USP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.
• 7 Stem Cells · Calcium · Osteocalcin
  Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications.Brown and white adipocyte like cells derived exosomes differentially regulate stemness, hormone secretion, apoptosis, and lipid metabolism in model cells.

Representative papers

1. Human umbilical cord mesenchymal stem cells enhance folliculogenesis and fertility in premature ovarian failure mice via regulating steroid synthesis. Stem cells (Dayton, Ohio)
2. hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle-Activating Capacity. Aging cell
3. Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
4. Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications. Journal of dentistry
5. Shockwave-Induced Myoblast Exosome-Like Vesicles: Emerging Drivers of Muscle Regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
6. Leek-Derived Exosome-like Nanoparticles Inhibit Hair Growth by Controlling the Differentiation Fate of Hair Follicle Stem Cells. ACS applied bio materials
7. HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma. Molecular biomedicine
8. Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats. Aging cell

Study types

Randomized trial / meta-analysis 11 · Clinical trial 1 · Human study 63 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Obesity 44 · Body Mass Index 36 · Weight Loss 14 · Body Composition 13 · Glucagon-Like Peptide-1 Receptor Agonists 12 · Semaglutide 10

Sub-areas (papers sharing 3+ concepts)

• 20 Weight Loss · Overweight · Body Mass Index
  Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis.A 12-week, double-blind, quasi-randomized, placebo-controlled study to evaluate the efficacy and safety of Coleus forskohlii (Forcslim) on body weight loss.
• 8 Dipeptidyl-Peptidase IV Inhibitors · Sodium-Glucose Cotransporter-2 Inhibitors · Diabetes Mellitus, Type 2
  Prescribing Trajectories in Type 2 Diabetes in the United States, 2019-2024.Long-Term Association Between GLP-1 Receptor Agonist Use and Incident Pancreatic Cancer: A Propensity Score-Matched Retrospective Cohort Study Using the TriNetX Network.
• 8 Semaglutide · Glucagon-Like Peptides · Tirzepatide
  Weight Loss-Dependent Changes in Body Composition and Bone Health in People With Obesity and Type 1 Diabetes Treated With Liraglutide, Semaglutide, or Tirzepatide.Cancer risk of glucagon-like peptide-1 receptor agonists for obesity: comparison with bariatric surgery and other weight-loss drugs.
• 8 Postoperative Complications · Obesity, Morbid · Pulmonary Embolism
  A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.Epigenetic Signature of the Metastable Epiallele VTRNA2-1: Adipose Dysfunction and Suboptimal Bariatric Outcomes.
• 6 Pediatric Obesity · Socioeconomic Factors · BMI z-score
  The temporal relationship among socioeconomic vulnerability, dietary intake, and childhood obesity across six European countries: longitudinal results from the Feel4Diabetes-study.\"Uncontrolled Hypertension Among Medicare Beneficiaries in Rural South Carolina.\".
• 5 Bioelectrical Impedance Analysis · Body Composition · Exercise
  Within-Day Timing of Concurrent Training Affects Inflammation and Body Composition in Young Adults With Obesity.Diagnostic accuracy and reliability of equations for the calculation of body fat mass percentage in the Colombian military population: a diagnostic test study.

Elsewhere on this page

• Trial readout A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.

Representative papers

1. Weight Loss-Dependent Changes in Body Composition and Bone Health in People With Obesity and Type 1 Diabetes Treated With Liraglutide, Semaglutide, or Tirzepatide. Diabetes/metabolism research and reviews
2. A coherent family support model (Co-Fam) for preventing and treating childhood overweight and obesity: protocol for a randomized hybrid type 2 effectiveness-implementation trial. BMC public health
3. The temporal relationship among socioeconomic vulnerability, dietary intake, and childhood obesity across six European countries: longitudinal results from the Feel4Diabetes-study. European journal of pediatrics
4. MFR, SVR and ASVR as promising biomarkers in overweight and obese population with obstructive sleep apnea syndrome: insights from an observational study. Annals of medicine
5. Perspectives of practitioners providing weight management support for young adults with obesity in an urban setting in Sri Lanka: a qualitative study. BMJ open
6. Cancer risk of glucagon-like peptide-1 receptor agonists for obesity: comparison with bariatric surgery and other weight-loss drugs. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
7. Prescribing Trajectories in Type 2 Diabetes in the United States, 2019-2024. Diabetes, obesity & metabolism
8. Diagnostic accuracy and reliability of equations for the calculation of body fat mass percentage in the Colombian military population: a diagnostic test study. BMJ military health

Study types

Randomized trial / meta-analysis 17 · Clinical trial 1 · Human study 42

Key concepts (papers in this area)

Anxiety 9 · Sleep Quality 8 · Fatigue 8 · Pain 8 · Pain Management 6 · Opioid-Related Disorders 5

Sub-areas (papers sharing 3+ concepts)

• 9 Quality of Life · Postural Balance · Multicenter Studies as Topic
  Effectiveness of Tuina Therapy for Patients With Chronic Fatigue Syndrome: Protocol for a Multicenter, Randomized, Open-Label, Assessor-Blinded, Parallel-Group Clinical Trial.Effectiveness of Yoga and Combined Exercise in Female With Rheumatoid Arthritis: Randomized Controlled Trial.
• 6 Plant Oils · Oils, Volatile · Lavandula
  Effects of lavender oil preparation silexan on different symptoms of major depression - results from a randomized, controlled trial.Effects of inhaled lavender essential oil on sleep quality, pain, and anxiety in ICU patients after curative hepatocellular carcinoma resection: a quasi-experimental study.
• 5 Delayed-Action Preparations · Cancer Pain · Buprenorphine
  Managing Cancer-Related Pain in Patients Receiving Long-Acting Buprenorphine for Opioid Use Disorder.Extended-release buprenorphine in adults with opioid use disorder involving poppy seed tea: An 18-month retrospective case series.

Elsewhere on this page

• Trial readout Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

Representative papers

1. Improving Sleep and PTSD Outcomes in Service Members: A Randomized Controlled Trial Examining the Long-Term Effects of an Integrated Treatment. Behavior therapy
2. Ketamine assisted psychotherapy to reduce chronic neuropathic pain: A mixed-methods randomized pilot trial. Med (New York, N.Y.)
3. The role of the transdiagnostic sleep and circadian intervention in adolescent bedtime and sleep quality: a pilot study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
4. Effect of active noise-cancelling headphones combined with music therapy on postoperative recovery quality after general anaesthesia for ankle fracture ORIF: a study protocol for a single-centre, four-arm 2×2 factorial randomised controlled trial in China. BMJ open
5. Effects of transcutaneous electrical acupoint stimulation versus acupressure on the trajectories of multidimensional adverse reactions to chemotherapy in breast cancer patients: a secondary analysis of a randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
6. The Effect of Aromatherapy on Fatigue and Sleep Quality in Intensive Care Nurses: A Randomised Placebo-Controlled Trial. Nursing in critical care
7. Effectiveness and psychological mechanism of group-based IMPROVE therapy for treatment seeking college students with problematic internet use in China: study protocol for a prospective, single-blind, randomised clinical trial. BMJ open
8. Evaluating the impact of cannabinoid extracts on chronic pain and quality of life in endometriosis patients - a pilot study. PloS one

Study types

Randomized trial / meta-analysis 1 · Human study 7 · Animal (in vivo) 40 · In vitro / preclinical 10

Key concepts (papers in this area)

Reactive Oxygen Species 27 · Photosensitizing Agents 20 · Photochemotherapy 19 · Biofilms 9 · Triple Negative Breast Neoplasms 7 · Immunogenic Cell Death 7

Sub-areas (papers sharing 3+ concepts)

• 15 Photochemotherapy · Photosensitizing Agents · Reactive Oxygen Species
  ZIF-90-PQ-based cascade nanoplatform for multimodal cooperative treatment of breast cancer.Electrostatically assembled gold nanocluster-enhanced porphyrinic metal-organic framework nanozymes for oxygen-boosted photodynamic therapy of hypoxic tumors.
• 11 Neoplasms · Nanoparticles · Photothermal Therapy
  Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy.Donor-engineered and H-aggregated squaraine-nanoprobe triggering tumor NIR-II fluorescence imaging with larger Stokes shift and type I photodynamic/photothermal synergistic therapy.
• 10 Anti-Bacterial Agents · Biofilms · Wound Healing
  A glucose-triggered cascade catalytic adhesive hydrogel enables mild photothermal-biofilm eradication for infected diabetic wounds.Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing.
• 6 Ultrasonic Therapy · Tumor Microenvironment · Sonodynamic Therapy
  Enzyme-Integrated Semiconducting Polymer Nanoplatform Remodels Physical and Metabolic Tumor Barriers for Potentiated Second Near-Infrared Region Photoimmunotherapy.Complex II inhibitor-loaded hollow piezoelectric nanocarriers potentiate respiration-driven piezocatalytic therapy for malignant pleural effusion.

Elsewhere on this page

• Key finding NIR Photocatalyst Induces Immunogenic Cell Death

Representative papers

1. Investigating the Role of Phenolic Acid Coformers in Enhancing the Physicochemical Properties of Enzalutamide Coamorphous Systems. The AAPS journal
2. Near-Infrared Light Photocatalysis Enables Synergistic Cancer Therapy. Angewandte Chemie (International ed. in English)
3. Shine bright, then fight: lectin-decorated gold nanostars for cancer theranostics. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
4. Donor-engineered and H-aggregated squaraine-nanoprobe triggering tumor NIR-II fluorescence imaging with larger Stokes shift and type I photodynamic/photothermal synergistic therapy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
5. Enhancing antimicrobial photodynamic inactivation through natural alkaloid-antiseptic synergy against methicillin-resistant Staphylococcus aureus. Journal of materials chemistry. B
6. Development of novel nanoliposomes co-loaded with ROR1 inhibitor and Ce6 for the treatment of EGFR-TKIs resistant NSCLC by synergistic targeted inhibitor therapy and photodynamic therapy. Journal of photochemistry and photobiology. B, Biology
7. ZIF-90-PQ-based cascade nanoplatform for multimodal cooperative treatment of breast cancer. International journal of pharmaceutics
8. Rosa damascena-derived exosome-like nanovesicles inhibit Salmonella enterica via membrane disruption, oxidative stress, and virulence suppression. World journal of microbiology & biotechnology

Study types

Human study 58

Key concepts (papers in this area)

Lupus Erythematosus, Systemic 10 · Hospitalization 9 · Lupus Nephritis 8 · Comorbidity 7 · Hospital Mortality 6 · Proteinuria 6

Sub-areas (papers sharing 3+ concepts)

• 9 Lupus Erythematosus, Systemic · Lupus Nephritis · Immunosuppressive Agents
  Clinical and immunological outcomes of rituximab-based, mycophenolate mofetil-based and cyclophosphamide-based treatment strategies for systemic lupus erythematosus with active kidney involvement from LOOPS registry.Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan.
• 7 Biopsy · Proteinuria · Glomerulonephritis, IGA
  Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease.Clinical Predictors of Non-Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic-Range Proteinuria.
• 6 Antiretroviral Therapy · HIV · HIV Infections
  Comorbidity and polypharmacy burden among people living with HIV in the United States stratified by age, sex, and race: updated evidence from a contemporary cohort.Incidence of comorbidities, healthcare resource utilization and costs among people with HIV.

Representative papers

1. Clinical Predictors of Non-Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic-Range Proteinuria. Nephrology (Carlton, Vic.)
2. Ethnic disparities in mortality following hospitalization for diabetic foot ulcer. Journal of diabetes and its complications
3. Clinical and immunological outcomes of rituximab-based, mycophenolate mofetil-based and cyclophosphamide-based treatment strategies for systemic lupus erythematosus with active kidney involvement from LOOPS registry. RMD open
4. Effect of prehospital cervical spine immobilization on mortality and neurological outcome in trauma patients: an observational cohort study with propensity score matching based on the trauma registry of the German trauma society (TraumaRegister DGU®). World journal of emergency surgery : WJES
5. Role of systemic hypoxia in the progression of diabetic retinopathy: a propensity-matched retrospective cohort study. BMJ open ophthalmology
6. Therapeutic plasma exchange across multiple organ systems in an Egyptian tertiary center: A seven-year real-world cohort study. PloS one
7. Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease. Annals of medicine
8. Risk of Heart Failure Hospitalization Associated With Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors Versus Erythropoiesis-Stimulating Agents: A Nationwide Claims-Based Cohort Study. Pharmacoepidemiology and drug safety

Study types

Randomized trial / meta-analysis 1 · Human study 9 · Animal (in vivo) 45 · In vitro / preclinical 2

Key concepts (papers in this area)

Gastrointestinal Microbiome 26 · Inflammatory Bowel Diseases 7 · NF-κB 7 · Toll-Like Receptor 4 7 · Colitis, Ulcerative 6 · Bile Acids and Salts 6

Sub-areas (papers sharing 3+ concepts)

• 16 NF-kappa B · Colitis · RAW 264.7 Cells
  Innovative rhein and hydroxy fatty acid ester prodrugs for the treatment of chronic inflammation.Oral Nanoarmored Lactobacillus rhamnosus with Inflammation Targeting and Scavenging Activities for Colitis Lesion-Specific Therapy.
• 11 Obesity · Diet, High-Fat · Energy Metabolism
  Chronic administration of a calafate (Berberis microphylla) polyphenol-rich extract modulates gut microbiota and metabolic homeostasis associated with thermogenic activation in high-fat diet-fed mice.A flavonoid-rich medicinal herb extract ameliorates high-fat diet-induced obesity and insulin resistance in mice.
• 9 Feces · Bacteria · Gastrointestinal Microbiome
  Effects of liraglutide on gut bacterial community dynamics.Gut microbiota dysbiosis shapes brain T-cell immunity in accelerated aging.
• 7 Bile Acids and Salts · Liver · Receptors, Cytoplasmic and Nuclear
  Effects of Hedan Tablets Combined With Simvastatin on Hyperlipidemia: Insights From Microbiomics and Metabolomics.ACAT3 controls hepatic cholesterol metabolism and modulates systemic energy homeostasis of male mice.

Representative papers

1. Effects of liraglutide on gut bacterial community dynamics. Microbiology spectrum
2. Comparative pharmacodynamic material basis of oral and colonic administration of Baitouweng decoction in experimental ulcerative colitis. Journal of ethnopharmacology
3. Phytosterol-induced modulation of gut microbial bile salt hydrolases ameliorates hyperlipidemia via taurohyodeoxycholic acid-mediated FXR antagonism. Gut microbes
4. Bifidobacterium adolescentis attenuates brown adipose tissue whitening and improves metabolic markers in high-fat diet-induced obese rats. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
5. Heyehui attenuates diet-induced obesity via regulating LEP/AMPK/ACC axis and restoring intestinal function in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology
6. Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome. Cell host & microbe
7. Strength training induces ABHD5-ATGL axis to counteract mesenteric fat accumulation in obese Swiss mice. Life sciences
8. A probiotic Bifidobacterium pseudocatenulatum converts hesperidin to bioactive hesperetin and improves metabolic dysfunction in aging mice. Gut microbes

Study types

Human study 14 · Animal (in vivo) 7 · In vitro / preclinical 34

Key concepts (papers in this area)

Molecular Dynamics Simulation 26 · Drug Discovery 24 · Ligands 16 · Protein Binding 13 · Thermodynamics 12 · Binding Sites 10

Sub-areas (papers sharing 3+ concepts)

• 13 Structure-Activity Relationship · Molecular Structure · Dose-Response Relationship, Drug
  Structure-Based Discovery of Fumiquinazolines as Skp2-Cks1 Protein-Protein Interaction Disruptors: Mechanistic Computational Insights and Experimental Validation.Discovery of novel xanthine oxidase inhibitors using deep learning-based composite molecular fingerprint: Screening, bioactivity assessment and binding behavior analysis.
• 13 Molecular Docking Simulation · Molecular Dynamics Simulation · Alzheimer Disease
  Molecular modeling design of antitrypanosomal pyrazolone derivatives targeting Chagas disease: QSAR, docking, molecular dynamics and free energy calculations.In Silico Decoding of Nonsteroidal Mineralocorticoid Receptor Antagonist Binding: Implications for Drug Design.
• 9 Drug Design · RNA · Models, Molecular
  Discovery of novel acridine based inhibitors of Bruton's tyrosine kinase (BTK) via pharmacophore modeling and machine learning-driven virtual screening followed by molecular dynamic studies.LinkLlama: Enabling a Large Language Model for Chemically Reasonable Linker Design.
• 5 Proteins · Protein Conformation · Ligands
  UniPoseScore: A Unified Graphormer3D-Based Framework for Protein-Ligand Binding Pose Scoring and Refinement.Unlocking Scalable Ligand Residence Time Predictions with Koffee Unbinding Kinetics Simulations.

Representative papers

1. Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1. ChemMedChem
2. Structure-Based Discovery of Fumiquinazolines as Skp2-Cks1 Protein-Protein Interaction Disruptors: Mechanistic Computational Insights and Experimental Validation. ChemMedChem
3. Discovery and biological evaluation of novel TLR2 antagonists through structure-based virtual screening and molecular dynamics simulations. Bioorganic chemistry
4. Molecular modeling design of antitrypanosomal pyrazolone derivatives targeting Chagas disease: QSAR, docking, molecular dynamics and free energy calculations. Journal of molecular modeling
5. Discovery of novel acridine based inhibitors of Bruton's tyrosine kinase (BTK) via pharmacophore modeling and machine learning-driven virtual screening followed by molecular dynamic studies. Journal of computer-aided molecular design
6. Data-Driven Critical Evaluation of the General Solubility Equation. Journal of chemical information and modeling
7. Inhibition and Molecular Recognition of Lactoperoxidase by Acetohydrazide-Based Sulfonamide Derivatives. Journal of molecular recognition : JMR
8. Design, synthesis, and evaluation of 3-fluoro-2-hydroxybenzaldehyde derivatives as TLR2 small molecule antagonists. Bioorganic chemistry