This month in biomedical research, distilled from PubMed. Updated 2026.09.27.

Study types

Randomized trial / meta-analysis 43 · Clinical trial 14 · Human study 295 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Double-Blind Method 28 · Body Mass Index 27 · Severity of Illness Index 26 · Hematopoietic Stem Cell Transplantation 24 · Case-Control Studies 21 · Pilot Projects 18

Sub-areas (papers sharing 3+ concepts)

• 26 T-Lymphocytes · Receptors, Chimeric Antigen · Immunotherapy, Adoptive
  Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients.Predictors of survival in adults with B-cell acute lymphoblastic leukemia treated with blinatumomab and/or inotuzumab ozogamicin in first salvage.
• 23 Overweight · Body Mass Index · Obesity
  Serum lipidomic profiles associated with Mediterranean diet in overweight and obese breast cancer survivors: an exploratory study.Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.
• 22 Biomarkers · ROC Curve · Case-Control Studies
  Leucine-rich alpha-2 glycoprotein as a predictor of primary non-response to anti-TNF-α therapy in biologic-naïve Egyptian IBD patients.Diagnostic value of lactate/albumin and lactate dehydrogenase/albumin ratios in newborns with hypoxic-ischemic encephalopathy.
• 13 Major Depressive Disorder · Area Under Curve · Depression
  Functional electrical stimulation for major depressive disorder: Protocol for a pilot randomized controlled trial.Efficacy, safety, and feasibility of youth-derived fecal microbiota transplantation among adults with type 1 diabetes mellitus: A protocol of Pilot Randomized Controlled Trial.
• 12 Heterocyclic Compounds, 3-Ring · Upadacitinib · Janus Kinase Inhibitors
  Anti-TNF, pan-JAK, and JAK1-selective inhibition differentially alter mechanisms of flow-mediated dilation in human microvessels.Efficacy and safety of duvakitug in patients with ulcerative colitis (RELIEVE UCCD): a phase 2b, randomised, placebo-controlled trial.
• 11 Venetoclax · Bridged Bicyclo Compounds, Heterocyclic · Antineoplastic Combined Chemotherapy Protocols
  Long-term outcomes of azacitidine, venetoclax, and gilteritinib in newly diagnosed FLT3-mutated AML.Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.

Elsewhere on this page

• Trial readout Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
• Trial readout Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

Representative papers

1. Feasibility and Efficacy of Lorlatinib in Japanese Patients With Relapsed/Refractory ALK-Aberrant Neuroblastoma. Pediatric blood & cancer
2. Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia. The New England journal of medicine
3. The long-term follow-up outcomes and transition rates across seven representative pediatric congenital surgical conditions: disease severity drives follow-up retention. Pediatric surgery international
4. Iodine status and thyroid function in children with multiple food allergy: a prospective cross-sectional study. Journal of pediatric endocrinology & metabolism : JPEM
5. Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients. Cancer chemotherapy and pharmacology
6. Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia. The New England journal of medicine
7. Hematopoietic Recovery and Safety Following Early Romiplostim Administration After Pediatric HSCT: A Prospective Randomized Pilot Study. Pediatric blood & cancer
8. Knowledge and practice of evidence-based mild traumatic brain injury guidelines among physicians providing emergency and trauma care in Israel. Israel journal of health policy research

Study types

Randomized trial / meta-analysis 26 · Clinical trial 25 · Human study 200 · Animal (in vivo) 10 · In vitro / preclinical 1

Key concepts (papers in this area)

Overall Survival 91 · Antineoplastic Combined Chemotherapy Protocols 72 · Biomarkers, Tumor 67 · Progression-Free Survival 61 · Lung Neoplasms 54 · Carcinoma, Non-Small-Cell Lung 43

Sub-areas (papers sharing 3+ concepts)

• 49 Breast Neoplasms · Neoadjuvant Therapy · Disease-Free Survival
  Chemotherapy type and survival in young BRCA1/2 carriers with HER2-negative early breast cancer.Efficacy of adjuvant chemotherapy for triple-negative early breast cancer with tumor size ≤ 1 cm and node-negative from the National Clinical Database-Breast Cancer Registry in Japan.
• 48 Immune Checkpoint Inhibitors · Immunotherapy · Tumor Microenvironment
  Tumor cell-expressed OX40L enhances the efficacy of PD-1 axis blockade in non-small cell lung cancer.Tumor mutational burden as a prognostic biomarker for survival and quality of life in metastatic colorectal cancer patients receiving anti-PD-1/PD-L1 immunotherapy: A retrospective cohort study.
• 33 Progression-Free Survival · Antineoplastic Combined Chemotherapy Protocols · Overall Survival
  Validation of the lung immune prognostic index in extensive-stage small cell lung cancer: Post hoc analysis of the caspian and IMpower133 phase 3 trials.Circadian timing of first-line chemoimmunotherapy is associated with survival in extensive-stage small cell lung cancer.
• 30 ErbB Receptors · Protein Kinase Inhibitors · Lung Neoplasms
  Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.Association Between EGFR Mutation Status and Out-of-field Recurrence in Locally Advanced Unresectable Non-small Cell Lung Cancer Treated With Chemoradiotherapy and Durvalumab Consolidation.
• 28 Pancreatic Neoplasms · Carcinoma, Pancreatic Ductal · pancreatic ductal adenocarcinoma
  Adjuvant oxaliplatin with S-1 (SOX) versus S-1 for stage II-III gastric cancer (CAPITAL): A randomized, open-label, phase 3 trial.Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study.
• 24 Glioma · Brain Neoplasms · Temozolomide
  Annexin A2 associated with bevacizumab resistance and infiltrative escape in glioblastoma.Impact of 5-ALA and sodium fluorescein on FLAIR volume extent of resection and survival in IDH-wildtype glioblastoma.

Elsewhere on this page

• Trial readout Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.
• Trial readout Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Representative papers

1. Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer - results from the phase II DETECT IVb trial. Breast cancer research and treatment
2. Neoadjuvant Gemcitabine Plus S-1 for Resectable Pancreatic Ductal Adenocarcinoma: A Propensity Score-matched Study. Anticancer research
3. Therapeutic management of resectable mismatch-repair deficient/microsatellite instability-high gastroesophageal adenocarcinoma: a real-world analysis from Austria. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
4. Prognostic Value of the Lung Immune Prognostic Index in Metastatic Renal Cell Carcinoma Treated With Second-Line Immunotherapy. International journal of urology : official journal of the Japanese Urological Association
5. Ovarian reserve as a measure of adjuvant chemotherapy benefit in hormone receptor positive (HR-positive), HER2-negative, node-positive breast cancer in SWOG S1007 (RxPONDER). Annals of oncology : official journal of the European Society for Medical Oncology
6. Impact of Tumor Genomic Profile on Adjuvant Chemotherapy Efficacy in Resected Pancreatic Adenocarcinoma: Results From the PRODIGE-24/CCTG PA6 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology
7. Crossing the milestone: landmark-based conditional survival after first-line CDK4/6 inhibitor therapy in HR+/HER2-metastatic breast cancer. Breast cancer (Tokyo, Japan)
8. Prognostic Value of Restaging [18F]FDG PET/CT in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [177Lu]Lu-PSMA-617 Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Study types

Randomized trial / meta-analysis 9 · Human study 235 · Animal (in vivo) 3 · In vitro / preclinical 4

Key concepts (papers in this area)

Biomarkers 61 · Machine Learning 57 · Risk Assessment 48 · Cardiovascular Diseases 35 · Heart Failure 25 · Mortality 24

Sub-areas (papers sharing 3+ concepts)

• 62 Cardiovascular Diseases · Diabetes Mellitus · Hypertension
  Haptoglobin and Immunoglobulin A2 Predict Cardiovascular Risk in Asymptomatic Subjects: The BioImage Study.Associations of Cardiovascular-Kidney-Metabolic Syndrome With All-Cause and Cardiovascular Death and the Progression of Cardiovascular-Kidney-Metabolic Syndrome Among Hong Kong Chinese People Over 2 Decades.
• 49 Predictive Learning Models · Machine Learning · Prediction Algorithms
  Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study.Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh.
• 46 Stroke Volume · Heart Failure · Natriuretic Peptide, Brain
  Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery.Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts.
• 12 tau Proteins · Alzheimer Disease · Amyloid beta-Peptides
  A multimodal model for clinically defined MCI integrating plasma biomarkers and brain microstructural features: a dual-cohort external validation study.Head-to-head comparison of plasma biomarker assays across platforms for amyloid pathology in a multicenter cohort.
• 8 Preoperative Period · Gastrectomy · Stomach Neoplasms
  Exploring the relationship between iron metabolism biomarkers and 28 day prognosis in patients with severe acute coronary syndrome: a multicenter retrospective cohort study.Dynamic potassium variability (K-CV) as an independent predictor of mortality in maintenance hemodialysis.
• 5 Osteoporosis · Bone Density Conservation Agents · Bone Density
  Nurse-Led Gastrointestinal Tolerability-Adapted Osteoporosis Care After Hip Fracture: 24-Month Implementation Outcomes.Impact of Prior Treatment and Predictive Factors in Sequential Romosozumab-Denosumab Therapy for Severe Osteoporosis.

Representative papers

1. Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate. Cardiovascular diabetology
2. Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery. Journal of the American Heart Association
3. Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. Cardiovascular diabetology
4. Neighborhood Contemporary Redlining and Racial Mortgage Lending Bias and Cardiovascular Outcomes in Women With Breast Cancer. Journal of the American Heart Association
5. The Predictive Value of The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score for One-Month Prognosis and First-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation. Brazilian journal of cardiovascular surgery
6. Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study. JMIR medical informatics
7. Comparing diagnostic tools for heart failure with preserved ejection fraction across community and clinical cohorts. Heart (British Cardiac Society)
8. Mitochondrial Ferritin in Subclinical Anthracycline-Induced Cardiotoxicity in Humans: A Pilot Study. Journal of cardiovascular translational research

Study types

Human study 23 · Animal (in vivo) 100 · In vitro / preclinical 72

Key concepts (papers in this area)

Structure-Activity Relationship 130 · Antineoplastic Agents 125 · Molecular Structure 116 · Dose-Response Relationship, Drug 114 · Cell Proliferation 110 · Apoptosis 77

Sub-areas (papers sharing 3+ concepts)

• 73 Apoptosis · Xenograft Model Antitumor Assays · Antineoplastic Agents
  Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies.New N-(isoxazol-3-yl)-4-(1,3,4-thiadiazol-3(2H)-yl)benzenesulfonamide derivatives as potent Aurora kinases inhibitors: Design, synthesis and anti-proliferative activity.
• 69 Drug Screening Assays, Antitumor · Cell Proliferation · Antineoplastic Agents
  Novel Steroidal (Thio)barbiturate Hybrids: From Design to Preclinical Assessment in Tumor Therapy.Design, synthesis, and biological evaluation of novel selenium-matrine hybrid compounds as topo I -targeted anticancer agents.
• 49 Molecular Docking Simulation · Structure-Activity Relationship · Molecular Structure
  Antineoplastic multi-targeted spiro[indoline-3,2'-pyrrolidines] incorporating urea function: Rational design, synthesis and bio-properties studies.Rational design and synthesis of pyrazole-based sulfonamides as dual carbonic anhydrase and PRAK-targeting anticancer agents.

Representative papers

1. Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies. Bioorganic chemistry
2. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry
3. Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis. Scientific reports
4. Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation. Bioorganic chemistry
5. Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazine derivatives as potent SYK inhibitors for solid tumor therapy. Bioorganic chemistry
6. A novel c-Met inhibitor containing chiral pyrrolidine side chain and its application as anti-tumor agents. European journal of medicinal chemistry
7. New N-(isoxazol-3-yl)-4-(1,3,4-thiadiazol-3(2H)-yl)benzenesulfonamide derivatives as potent Aurora kinases inhibitors: Design, synthesis and anti-proliferative activity. Bioorganic chemistry
8. Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib. European journal of medicinal chemistry

Study types

Human study 25 · Animal (in vivo) 103 · In vitro / preclinical 56

Key concepts (papers in this area)

Anti-Bacterial Agents 95 · Hydrogels 59 · Nanoparticles 41 · Wound Healing 36 · Escherichia coli 35 · Staphylococcus aureus 34

Sub-areas (papers sharing 3+ concepts)

• 47 Wound Healing · Staphylococcus aureus · Hydrogels
  A novel borneol-loaded PLGA/Chitosan nanoparticles: Synthesis, characterization and evaluation of antioxidant, antibacterial, wound healing and cytotoxic activity on A549 cells.Plasma-activated thermosensitive Pluronic F-127 hydrogel as an antimicrobial dressing for infected wound healing.
• 34 Drug Delivery Systems · Drug Carriers · Drug Liberation
  pH-Responsive Chitosan-Coated Spanlastic Nanovesicles for Enhanced Lung-Targeted Delivery of Brilliant Blue G in Acute Lung Injury.Betaine-Modified Chitosan Nanoparticles Enhance Oral Insulin Delivery via pH-Triggered Charge Switching, Mucus Penetration, and Lysosomal Escape.
• 25 beta-Lactamases · Bacterial Proteins · Klebsiella pneumoniae
  Chelate-conjugated β-lactams resensitize metallo-β-lactamase IMP-1-producing gram-negative bacteria against carbapenem antibiotics.Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy.
• 21 Structure-Activity Relationship · Dose-Response Relationship, Drug · Gram-Positive Bacteria
  Design and synthesis of novel baicalein-isoxazoles based scaffolds and their anti-microbial potential: in vitro and in silico evaluation.Novel thioether and thioester-based derivatives as promising antibacterial agents with antioxidant potential: design, synthesis, and in silico studies.
• 20 Biocompatible Materials · Materials Testing · Gelatin
  Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices.Metal Ion-Triggered Collapsed Hydrogels as Materials for Bacterial Population Control.
• 19 Plant Extracts · Metal Nanoparticles · Silver
  Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy.Combined experimental and molecular docking investigation of a cyclodextrin-myrrh oil inclusion complex: implications for solubility and antibacterial activity.

Representative papers

1. Chelate-conjugated β-lactams resensitize metallo-β-lactamase IMP-1-producing gram-negative bacteria against carbapenem antibiotics. Microbiology spectrum
2. Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices. ACS applied bio materials
3. Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype. Antimicrobial agents and chemotherapy
4. Extensively drug-resistant ESBL-producing enterobacterales and coexisting antimicrobial resistance genes are associated with mortality in critically ill patients with cancer. Scientific reports
5. Phenotypic and molecular detection of efflux pump and expression profiling genes in Klebsiella pneumoniae exposed to ciprofloxacin and amoxicillin/clavulanic acid. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
6. Essential role of the leucine-293 for the AmpC β-lactamase in the resistance to cefepime, cefiderocol, and new β-lactams/β-lactamase inhibitor combinations in Enterobacter hormaechei. International journal of antimicrobial agents
7. Antimicrobial activity of aztreonam/avibactam and molecular characterization of Enterobacterales not susceptible to ceftazidime/avibactam and/or meropenem/vaborbactam from US medical centres (2016-2024). The Journal of antimicrobial chemotherapy
8. Self-Assembling Amphiphilic Cationic Peptide-Based Nanoarchitectures for Soft Biomaterials with Potential Antimicrobial Activity against Clinically Isolated Multidrug-Resistant Bacteria. ACS applied bio materials

Study types

Randomized trial / meta-analysis 17 · Clinical trial 1 · Human study 157

Key concepts (papers in this area)

Neoplasms 58 · Quality of Life 56 · Cancer Survivors 24 · Anxiety 21 · Palliative Care 18 · Depression 17

Sub-areas (papers sharing 3+ concepts)

• 23 Palliative Care · Advanced Cancer · Depression
  Spiritual wellbeing in advanced cancer patients receiving palliative care in a tertiary cancer centre in northern Kerala, India: a qualitative study.Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer.
• 21 Cancer Survivors · Health Services Needs and Demand · Neoplasms
  A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial.International phase IV field study to validate the European Organisation for Research and Treatment of Cancer questionnaire for assessing the health-related quality of life of cancer survivors: The EORTC QLQ-SURV100.
• 19 Exercise · Exercise Therapy · Behavior Change
  A qualitative study of cancer survivors' exercise behaviour 4 months after a telerehabilitation program.Feasibility of a remote and home-based personalised exercise programme in cancer survivors with lymphoedema.
• 16 Communication · Physician-Patient Relations · Communication Barriers
  Experiences of healthcare encounters among patients using complementary and alternative medicine alongside oncology or palliative care: a qualitative interview study in Sweden.Psychosocial and supportive care in radiation therapy: a qualitative comparison of Norway and Canada.
• 13 Longitudinal Studies · Postural Balance · Fatigue
  Exploring the feasibility of exercise training during (neo)adjuvant chemotherapy in women with early-stage breast cancer: a pilot study examining immune and metabolic outcomes.Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.
• 12 Multicenter Studies as Topic · Randomized Controlled Trials as Topic · Sleep Quality
  Feasibility of an N-of-1 trial using a crossover design to evaluate music therapy in patients with breast cancer undergoing adjuvant chemotherapy: a multicentre pilot study protocol in two Italian centres (IMPACT-CASTA DIVA).Effectiveness of Tuina Therapy for Patients With Chronic Fatigue Syndrome: Protocol for a Multicenter, Randomized, Open-Label, Assessor-Blinded, Parallel-Group Clinical Trial.

Elsewhere on this page

• Trial readout Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.

Representative papers

1. Evaluating an innovative support programme for older long-term cancer survivors (IMPULS-A): protocol for a randomised controlled trial. BMJ open
2. Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer. Psycho-oncology
3. Effect of active noise-cancelling headphones combined with music therapy on postoperative recovery quality after general anaesthesia for ankle fracture ORIF: a study protocol for a single-centre, four-arm 2×2 factorial randomised controlled trial in China. BMJ open
4. Exploring the understanding and management of anxiety from cancer in Latino/a older adults and their caregivers. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
5. Children's participation in assent to paediatric oncology research: experiences of children, siblings and parents. Trials
6. Spiritual wellbeing in advanced cancer patients receiving palliative care in a tertiary cancer centre in northern Kerala, India: a qualitative study. BMJ open
7. Psychosocial and supportive care in radiation therapy: a qualitative comparison of Norway and Canada. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
8. Network analysis of head and neck symptoms and fear of cancer recurrence in postoperative laryngeal cancer patients: simulation-based intervention modeling. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Study types

Human study 6 · Animal (in vivo) 81 · In vitro / preclinical 9

Key concepts (papers in this area)

Signal Transduction 41 · Inflammation 35 · NF-kappa B 29 · Anti-Inflammatory Agents 24 · Cytokines 23 · TNF-α 19

Sub-areas (papers sharing 3+ concepts)

• 17 Toll-Like Receptor 4 · Neuroprotective Agents · NF-kappa B
  CCL5 mRNA-enriched small extracellular vesicles from renal tubular epithelial cells enhance macrophage inflammatory responses in diabetic nephropathy.Procyanidin B2 ameliorates hypoxic-ischemic brain damage in neonatal rats by inhibiting pyroptosis via the TLR4/NF-κB signaling pathway.
• 15 Interleukin-6 · Oxidative Stress · Immunotherapy
  Ellagic acid regulates astrocytic responses under inflammatory conditions in primary astrocyte cultures: effects on oxidative stress, inflammatory cytokines, and glycogen synthase kinase-3β.Mitochondrial-targeted cerium dioxide nanozymes enable the efficient regulation of oxidative stress and inflammation in acute lung injury.
• 13 Structure-Activity Relationship · Molecular Structure · Dose-Response Relationship, Drug
  Bioassay-guided discovery of anti-inflammatory sesquiterpenoids from Lindera aggregata (Sims) Kosterm.Structure-Guided Optimization of PDE9A Inhibitors Tackling Neuroinflammation: A Combined Computational and In Vitro Study.
• 12 Anti-Inflammatory Agents · Plant Extracts · RAW 264.7 Cells
  From grey relational-network pharmacology screening to mechanism elucidation: 4-methoxy-2- (3-methylethoxyethane) -phenylisobutyrate from Pimpinella diversifolia essential oil alleviates D-GalN/LPS-induced ALI by targeting the GSK-3β/NF-κB axis.Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.
• 10 Drugs, Chinese Herbal · Interleukin-17 · Neurons
  Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration.Mechanism of Qibai Pingfei Capsule in ameliorating COPD-associated inflammation via the ABCA3/PPARγ/NF-κB pathway: A serum-targeted metabolomics and lipidomics study.
• 10 TNF-α · IL-6 · IL-1β
  Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis.Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes.

Representative papers

1. Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis. Fitoterapia
2. In vivo and molecular docking studies of Micromeria imbricata var. imbricata extract reveal alleviation of the DSS-induced IBD phenotype via interaction with key inflammatory mediators. Journal of ethnopharmacology
3. Structural elucidation of an active pectin against inflammatory bowel disease from the roots of Sanguisorba officinalis and its protection effect. Carbohydrate polymers
4. Bioassay-guided discovery of anti-inflammatory sesquiterpenoids from Lindera aggregata (Sims) Kosterm. Bioorganic chemistry
5. Proteomics-based characterization of apigenin-mediated anti-inflammatory effects in TNF-α-stimulated ARPE-19 cells. International immunopharmacology
6. From grey relational-network pharmacology screening to mechanism elucidation: 4-methoxy-2- (3-methylethoxyethane) -phenylisobutyrate from Pimpinella diversifolia essential oil alleviates D-GalN/LPS-induced ALI by targeting the GSK-3β/NF-κB axis. Journal of ethnopharmacology
7. Tuihong formula attenuates DNCB-induced atopic dermatitis in mice via suppression of MAPK/NF-κB signaling and epidermal barrier restoration. Journal of ethnopharmacology
8. Jiawei Taohe Chengqi decoction improves intestinal barrier damage in sepsis by modulating Notch-mediated macrophage polarization. Cellular immunology

Study types

Randomized trial / meta-analysis 1 · Human study 10 · Animal (in vivo) 69 · In vitro / preclinical 12

Key concepts (papers in this area)

Reactive Oxygen Species 47 · Photosensitizing Agents 22 · Ferroptosis 20 · Photochemotherapy 19 · Triple Negative Breast Neoplasms 12 · Immunogenic Cell Death 11

Sub-areas (papers sharing 3+ concepts)

• 25 Photochemotherapy · Photosensitizing Agents · Anti-Bacterial Agents
  ZIF-90-PQ-based cascade nanoplatform for multimodal cooperative treatment of breast cancer.Tumor Microenvironment-Triggered Nanocrystal-to-Nanocrystal Transformation for RNA-Boosted Photo-STING Therapy.
• 18 Immunotherapy · cGAS-STING Signaling Pathway · Tumor Microenvironment
  Molecular Engineering Boosts Photon-Activated Immunotherapy for Prostate Cancer Through Concurrent Pyroptosis and cGAS-STING Pathway Activation.Triple-Microenvironment Decoding Enables Logic-Unlocked Precision Photoimmunotherapy.
• 17 Ferroptosis · GPX4 · Sorafenib
  Metabolic PANoptosis orchestrated by porous silkworm-like PtFeCoTeMn high-entropy nanozyme for synergistic cancer therapy.Folic-Acid-Modified Fe-TCPP Metal-Organic Frameworks as Sonosensitive Agents and siATAD3A Carriers for Sonodynamic Co-Gene-Ferroptosis Therapy in Triple-Negative Breast Cancer.
• 9 Prodrugs · Antineoplastic Agents · Taxoids
  Low-Density Lipoprotein-Mimetic Nanoparticles Codelivering Self-Activated Cabazitaxel Prodrug and Verteporfin for Tumor Chemophotodynamic Therapy and Immune Activation.Caged Glycan-Antibody Conjugates for Tumor-Selective Activation of Lysosome-Targeting Chimeras.

Elsewhere on this page

• Key finding NIR Photocatalyst Induces Immunogenic Cell Death

Representative papers

1. Metabolic regulation-driven nanoparticles for tumor vulnerabilization and enhanced photodynamic therapy. Journal of controlled release : official journal of the Controlled Release Society
2. Low-Density Lipoprotein-Mimetic Nanoparticles Codelivering Self-Activated Cabazitaxel Prodrug and Verteporfin for Tumor Chemophotodynamic Therapy and Immune Activation. Molecular pharmaceutics
3. Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation. Journal of hematology & oncology
4. Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy. Molecular biomedicine
5. A Minimal Hemin-Albumin Nanozyme with Peroxidase-like Activity Enabling Tyrosine-Crosslinked Hydrogel Formation. ACS applied materials & interfaces
6. A ClO--responsive porphyrin prodrug for fluorescence imaging and combined chemo-photodynamic treatment of hepatocellular carcinoma cells. Journal of photochemistry and photobiology. B, Biology
7. Near-Infrared Light Photocatalysis Enables Synergistic Cancer Therapy. Angewandte Chemie (International ed. in English)
8. Targeted catalytic eradication of antibiotic-resistant Helicobacter pylori by a pH-activated Fe-doped nanozyme. Journal of colloid and interface science

Study types

Human study 32 · Animal (in vivo) 11 · In vitro / preclinical 34

Key concepts (papers in this area)

Limit of Detection 53 · Biosensing Techniques 41 · Electrochemical Techniques 26 · Gold 23 · Gold Nanoparticles 15 · Immunoassay 11

Sub-areas (papers sharing 3+ concepts)

• 22 Gold · Metal Nanoparticles · Gold Nanoparticles
  Aptakiss-guided CRISPR/Cas13a signal amplification for ultrasensitive FEN1 detection using CsPbBr3@PDA@AuNPs-based electrochemiluminescence platform.Gold-graphene based nanofiber biosensor for selective electrochemical identification of CD105-positive canine mesenchymal stem cells.
• 22 Electrochemical Techniques · Biosensing Techniques · CRISPR-Cas Systems
  An electrochemiluminescence biosensor for sulfadimethoxine detection based on enzymatic DNA walker-activated CRISPR/Cas12a cascade for signal enhancement.A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone.
• 13 Fluorescent Chemosensor Compounds · Spectrometry, Fluorescence · Carbon Quantum Dots
  Molecular-level biomimetic integration of phosphorus-doped graphene quantum dots with silver nanoparticles for highly stable and active nanozymes: Application in ultrasensitive ascorbic acid detection.A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles.

Representative papers

1. Sustainable Synthesis of N, S-Enriched Carbon Sensor from Euphorbia royleana Latex for Low-Cost Fluorescence Based Detection of Arsenic Ions. Bulletin of environmental contamination and toxicology
2. Interfacial tripedal DNA walking coupled with oxygen-depletion/ECL-RET dual quenching for femtomolar detection of Tobacco Mosaic Virus RNA in plant extracts. Mikrochimica acta
3. Aptakiss-guided CRISPR/Cas13a signal amplification for ultrasensitive FEN1 detection using CsPbBr3@PDA@AuNPs-based electrochemiluminescence platform. Biosensors & bioelectronics
4. A Dual-Mode Fluorescent and Colorimetric Biosensor Based on AuNPs@RCA Nanogel-Integrated Multipedal DNA Walker for Ultrasensitive miRNA Detection. ACS applied materials & interfaces
5. A dual colorimetric and fluorescent sensor for non-enzymatic glucose detection via catalytic reaction with o-phenylenediamine mediated by carbon dot-decorated Fe3O4 nanoparticles. Analytica chimica acta
6. A novel fluorescent sensor based on CdTe quantum dots and DTAB-modified Au nanoparticles through aggregation-induced fluorescence recovery for the detection of l-lysine. Journal of the science of food and agriculture
7. Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage. Analytica chimica acta
8. A Sm-MOF@Ag electrochemiluminescence immunosensor mediated by CuBi2O4@PDA dual-mode quenching for sensitive detection of anti-Müllerian hormone. Mikrochimica acta

Study types

Human study 7 · Animal (in vivo) 16 · In vitro / preclinical 52

Key concepts (papers in this area)

Chemistry, Pharmaceutical 47 · Solubility 32 · Drug Compounding 29 · Drug Liberation 27 · Bulk Drugs 26 · Tablets 23

Sub-areas (papers sharing 3+ concepts)

• 24 Tablets · Excipients · Drug Compounding
  Direct Powder Extrusion of Atorvastatin 3D-Printed Tablets for Immediate-Release: Solid-State Characterization and Dissolution Performance.A structure dosage form approach for solubility and dissolution rate enhancement.
• 21 Particle Size · Nanoparticles · Liposomes
  Syringic Acid-Loaded Emulsomes as a Neuroprotective Delivery System: Formulation Optimization and In-Vivo Pharmacokinetic Evaluation.Formulation, Optimization and Characterization of Acetazolamide-Loaded Solid Lipid Nanoparticles for Glaucoma Treatment: In-Vitro and In-Vivo Study.
• 11 Crystallization · Calorimetry, Differential Scanning · Bulk Drugs
  Novel Hybrid Polymer-Lipid-Based Formulations for Enhanced Dissolution Rates of Poorly Water-Soluble Drugs: A Quality by Design (QbD) Approach via Hot Melt Extrusion.Scalable generation of droplet-templated amorphous solid dispersions using continuous antisolvent extraction.
• 9 Drug Release Kinetics · Kinetics · Delayed-Action Preparations
  Formulation and assessment of long-acting pharmaceutical co-formulated crystals.Development of Carboxymethyl Cellulose-Gelatin Aerogels for Urea Delivery.

Representative papers

1. Ultrasonic evaluation of permanent moisture impact on microstructural and micro-viscoelastic properties of pharmaceutical tablets: a proof of concept study. International journal of pharmaceutics
2. Real-Time Monitoring of Tablet API Concentration and Bioavailability via Dissolution Kinetics in Simulated Stomach Fluid by T-Ray Transmission Technique. AAPS PharmSciTech
3. Impact of mixing method on amorphous solid dispersions fabricated via vacuum compression molding: dissolution and degree of fusion. International journal of pharmaceutics
4. Novel Hybrid Polymer-Lipid-Based Formulations for Enhanced Dissolution Rates of Poorly Water-Soluble Drugs: A Quality by Design (QbD) Approach via Hot Melt Extrusion. AAPS PharmSciTech
5. Low-temperature FDM 3D printing of immediate-release glipizide tablets: formulation optimization, solid-state characterization, and dose customization. International journal of pharmaceutics
6. Scalable generation of droplet-templated amorphous solid dispersions using continuous antisolvent extraction. International journal of pharmaceutics
7. A structure dosage form approach for solubility and dissolution rate enhancement. International journal of pharmaceutics
8. Dissolution Enhancement by Binding Agents: A Potential Shortcut to Improving Bioavailability? The AAPS journal

Study types

Randomized trial / meta-analysis 6 · Clinical trial 1 · Human study 64

Key concepts (papers in this area)

Robotic Surgical Procedures 30 · Postoperative Complications 26 · Length of Stay 17 · Operative Time 10 · Robot-Assisted Radical Prostatectomy 7 · Gastrectomy 6

Sub-areas (papers sharing 3+ concepts)

• 19 Laparoscopy · Robotic Surgical Procedures · Overall Survival
  Impact of Non-curative Endoscopic Submucosal Dissection on Minimally Invasive Distal Gastrectomy and on Robotic Versus Laparoscopic Approaches in pT1 Gastric Cancer.Perioperative safety and survival outcomes of robot-assisted partial nephrectomy in elderly patients with localized renal cell carcinoma: an overlap-weighted Asian cohort study.
• 14 Prostatic Neoplasms · Prostatectomy · Robot-Assisted Radical Prostatectomy
  TAPESTRY study: impact of prior transurethral resection of the prostate on outcomes after robot-assisted radical prostatectomy: a propensity score-matched cohort study.Total periurethral anatomical preservation during single-port extraperitoneal robot-assisted radical prostatectomy using a modified hood technique.
• 5 Lung Neoplasms · Pneumonectomy · Robotic Assisted Thoracic Surgery
  Clinical performance of da Vinci 5 versus Xi for robotic anatomic lung resection: a propensity-weighted analysis.Biological surgical stress after minimally invasive lung resection for non-small cell lung cancer: comparing robotic and thoracoscopic surgical platforms.

Elsewhere on this page

• Trial readout A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.

Representative papers

1. Are we missing an important point? Risk factors for intraoperative complications and additional procedures when performing post-chemotherapy RPLND for testicular tumors. Japanese journal of clinical oncology
2. Clinical performance of da Vinci 5 versus Xi for robotic anatomic lung resection: a propensity-weighted analysis. Journal of robotic surgery
3. Side-specific lower detrusor apron-sparing robot-assisted radical prostatectomy: functional and oncological outcomes. World journal of urology
4. Preservation of the superior fascia of the pelvic diaphragm is associated with greater continence recovery after non-nerve-sparing robot-assisted radical prostatectomy. Journal of robotic surgery
5. Total periurethral anatomical preservation during single-port extraperitoneal robot-assisted radical prostatectomy using a modified hood technique. Journal of robotic surgery
6. Perioperative safety and survival outcomes of robot-assisted partial nephrectomy in elderly patients with localized renal cell carcinoma: an overlap-weighted Asian cohort study. Journal of robotic surgery
7. Single-port robotic prostatectomy is associated with higher same-day discharge and reduced length of stay: a NSQIP analysis. World journal of urology
8. Robot‑assisted thoracoscopic surgery for pediatric mediastinal tumors: a 5‑year experience with 168 cases. Journal of robotic surgery

Study types

Human study 4 · Animal (in vivo) 39 · In vitro / preclinical 22

Key concepts (papers in this area)

Drug Resistance, Neoplasm 26 · Breast Neoplasms 22 · Doxorubicin 13 · MCF-7 Cells 13 · Ovarian Neoplasms 10 · Cisplatin 8

Sub-areas (papers sharing 3+ concepts)

• 14 MCF-7 Cells · Breast Neoplasms · Cell Proliferation
  Harnessing light and ultrasonic vibration: efficient amphiphilic phthalocyanine-based sensitizers for combined sono-photodynamic therapy of breast cancer.The Phosphatidylinositol 3-Kinase (PI3K) Inhibitor Inavolisib Has Breast-cancer Synergy Combined With Recombinant Methioninase But Not on Normal Cells.
• 13 Platinum · Molecular Structure · Ovarian Neoplasms
  Functionalization of cyclotriveratrilene with tetrazole and phenothiazine for doxorubicin coordination and delivery.Birinapant enhances cisplatin sensitivity in epithelial ovarian cancer through modulation of apoptotic and survival signaling pathways.
• 10 Lung Neoplasms · Cell Movement · Carcinoma, Non-Small-Cell Lung
  ZUP1 contributes to cisplatin resistance and treg-related signaling in non-small cell lung cancer.Ion channel TRPML2 (MCOLN2) promotes ovarian cancer metastasis and chemoresistance.
• 7 Molecular Dynamics Simulation · Immunotherapy · Drug Resistance, Multiple
  Leveraging a Deep Learning Model and Computational Screening for the Discovery of ABCG2 Inhibitors against Drug-Resistant Breast Cancer.A clinical data- and AI-supported engineered fusion vesicle system for enhanced tumor-targeted drug delivery and immunochemotherapeutic synergy.
• 7 doxorubicin resistance · Hypoxia-Inducible Factor 1, alpha Subunit · Cyclin-Dependent Kinase 6
  P53 Competitively Binds P300 to Suppress HIF-1α/TFRC-Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer.CDK8/19 inhibition prevents adaptive resistance to CDK4/6 inhibitors in vitro and in vivo.
• 6 Drug Carriers · Vorinostat · Nanoparticles
  Vorinostat nanoformulation triggers cell cycle blockade and apoptosis for colorectal cancer therapy.Rutin-enabled improved systemic exposure of doxorubicin via nanostructured lipid carriers: a proof of concept through novel LC-MS/MS analysis.

Representative papers

1. Birinapant enhances cisplatin sensitivity in epithelial ovarian cancer through modulation of apoptotic and survival signaling pathways. Cancer chemotherapy and pharmacology
2. The Phosphatidylinositol 3-Kinase (PI3K) Inhibitor Inavolisib Has Breast-cancer Synergy Combined With Recombinant Methioninase But Not on Normal Cells. In vivo (Athens, Greece)
3. CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas. Cancer chemotherapy and pharmacology
4. Expanding the scope of platinum-NHC complexes: trans-Pt(II) and Pt(0) architectures for ovarian cancer treatment. Dalton transactions (Cambridge, England : 2003)
5. Synergy of KRAS-inhibitor Daraxonrasib Combined With Recombinant Methioninase on Pancreatic-cancer Cells But Not Normal Cells. Anticancer research
6. A Platinum(IV) Metallo-Stapling Approach to Tumor-Specific Prodrugs for Targeted Chemo-Immunometabolic Cancer Therapy. Angewandte Chemie (International ed. in English)
7. Synthesis and cytotoxicity evaluation of steroidal 17β-hydroxy-17α-methylisoxazoles. Steroids
8. Targeting ALDH2 with Alda-1 to reverse cisplatin resistance in lung adenocarcinoma. Cancer chemotherapy and pharmacology

Study types

Randomized trial / meta-analysis 12 · Human study 52 · Animal (in vivo) 1

Key concepts (papers in this area)

Ischemic Stroke 18 · Stroke 18 · Atrial Fibrillation 13 · Acute Kidney Injury 8 · Direct Oral Anticoagulants 7 · Aspirin 7

Sub-areas (papers sharing 3+ concepts)

• 13 Atrial Fibrillation · Stroke · Anticoagulants
  Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial.Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk.
• 8 Functional Outcomes · Fibrinolytic Agents · Brain
  Butylphthalide combined with tenecteplase in mild disabling acute ischaemic stroke in China (BENEFIT-2): study protocol for a multicentre, randomised, double-blind, active-controlled trial.Early-event pathways to 6-month death or dependency after ischemic stroke: Secondary analysis of the international stroke trial.
• 6 Clopidogrel · Platelet Aggregation Inhibitors · Dual Antiplatelet Therapy
  Clopidogrel Versus Dual-Antiplatelet Therapy for Long-Term Maintenance After Coronary Stenting in Ischemic and Bleeding Birisk Patients With Acute Coronary Syndromes and Diabetes: A Prespecified Subgroup Analysis of the OPT-BIRISK Trial.Clopidogrel vs Aspirin According to Diabetes Mellitus: A Prespecified Analysis of the SMART-CHOICE 3 Trial.

Representative papers

1. Timing of anticoagulation after emergency endovascular therapy for acute ischaemic stroke with atrial fibrillation (TIMERS): protocol for a randomised controlled trial. BMJ open
2. Reduced-dose direct oral anticoagulant versus antiplatelet strategies after left atrial appendage occlusion. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
3. Etiologic spectrum of direct oral anticoagulant breakthrough stroke in atrial fibrillation: The role of pseudo-failure and non-cardioembolic mechanisms. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
4. Effect of periprocedural antithrombotic medication on functional outcome and symptomatic intracranial hemorrhage in patients with carotid tandem lesions. BMJ open
5. A biomimetic nano-platelet as an antidote for dual antiplatelet therapy-induced bleeding. Journal of controlled release : official journal of the Controlled Release Society
6. Early-event pathways to 6-month death or dependency after ischemic stroke: Secondary analysis of the international stroke trial. Journal of the neurological sciences
7. API-CAT investigators' decisions on anticoagulation following extended treatment for cancer-associated thrombosis. European heart journal. Cardiovascular pharmacotherapy
8. Stroke and systemic embolism following atrial fibrillation ablation: the EMBOL-AF Global Registry. European heart journal

Study types

Randomized trial / meta-analysis 1 · Human study 10 · Animal (in vivo) 52 · In vitro / preclinical 1

Key concepts (papers in this area)

Alzheimer Disease 24 · Hippocampus 23 · Amyloid beta-Peptides 14 · Cognitive Dysfunction 13 · Microglia 13 · Proteomics 9

Sub-areas (papers sharing 3+ concepts)

• 12 Cognitive Dysfunction · Cognitive Enhancement · Maze Learning
  Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation.Triangulating the Neuroprotective Mechanisms of Pterostilbene in Hyperhomocysteinemia Induced Cognitive Impairment: Insights from In Silico, Proteomics, and Experimental Validation.
• 11 Amyloid beta-Peptides · Alzheimer Disease · Biomarkers
  CSF neuroinflammatory biomarkers are associated with amyloid-β42/40, tau pathology, and cognitive impairment across the Alzheimer's disease spectrum.Fabrication of Mesoporous Manganese Nanoparticles Incorporated Aβ-Peptide Inhibits Aβ Aggregation and Alleviates Neuroinflammation Against Alzheimer's Disease.
• 10 Alzheimer Disease · Microglia · Reactive Oxygen Species
  Human amniotic mesenchymal stromal cell-derived extracellular vesicles reprogram microglia and prevent neurodegeneration in experimental models of Alzheimer's disease.LPI alleviates Alzheimer's disease pathology via the GPR55 receptor.
• 7 Depression · Bax · Stroke
  Xiaoyaosan reactivates the muscle-brain axis via FNDC5/Irisin to ameliorate LPS-induced depression.Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects.
• 5 Seizures · Pentylenetetrazole · Epilepsy
  Gastrodia elata Blume and Acorus tatarinowii Schott mixtures alleviate pentylenetetrazol-induced seizures in mice: association with NLRP3 inflammasome signaling changes.Carbamazepine preserves systemic ionic homeostasis and hippocampal Atp1a1 expression following pentylenetetrazol-induced seizures in rats.

Representative papers

1. Triangulating the Neuroprotective Mechanisms of Pterostilbene in Hyperhomocysteinemia Induced Cognitive Impairment: Insights from In Silico, Proteomics, and Experimental Validation. Neuromolecular medicine
2. High-intensity interval training modulates APP expression and reduces neuronal apoptosis in a β-amyloid-induced model of Alzheimer's disease: hippocampal evidence. Experimental brain research
3. SVHRSP Attenuates PTZ-Induced Seizure-Like Behavior in C. elegans: Involvement of HSF-1 and Associated Changes in GABAergic Markers and Mitochondrial Homeostasis. Neurochemical research
4. Neuroprotective and cognitive-enhancing effects of γ-Oryzanol in bile duct ligation-induced hepatic encephalopathy in rats. Metabolic brain disease
5. Effects of Intravenously Administered Plasma from Exercise-Trained Donors on Mitochondrial Respiration in a Rat Model of Alzheimer's Disease. Medicine and science in sports and exercise
6. Nose-to-brain delivery of empagliflozin-loaded nanostructured lipid carriers incorporated in-situ gel: Biopharmaceutical evaluation for Alzheimer's disease. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
7. Herb pair of Eucommiae Folium and Gardeniae Fructus enhanced hippocampal PACAP-mediated neuroplasticity via the non-classic downstream PI3K/AKT signaling to exert antidepressant effects. Journal of ethnopharmacology
8. Zingerone mitigates cognitive and motor impairments in a D-galactose-induced brain aging model: Role of oxidative stress and neuroinflammation. Molecular biology reports

Study types

Clinical trial 2 · Human study 3 · Animal (in vivo) 53 · In vitro / preclinical 2

Key concepts (papers in this area)

Macrophages 28 · CD8+ T cells 12 · Dendritic Cells 9 · CD8-Positive T-Lymphocytes 8 · T-Lymphocytes, Regulatory 7 · Tumor-Associated Macrophages 5

Sub-areas (papers sharing 3+ concepts)

• 8 M1 Macrophages · M2 Macrophages · THP-1 Cells
  A Liposomal Nanovaccine Reprograms Post-Ablation Macrophages to Sustain Antitumor Immunity in Hepatocellular Carcinoma.Gastric Cancer-Derived Exosomal MATN3 Favours Immunosuppressive Tumour Microenvironment by Activating Autophagy in an EGFR/ELK1/ATG12 Signalling Dependent Manner.
• 7 RNA, Messenger · Multiple Sclerosis · Lipids
  Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte-mediated cancer immunotherapy.A tolerogenic mRNA-LNP vaccine alleviates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis.
• 7 CD8+ T cells · Thymic Stromal Lymphopoietin · Programmed Cell Death 1 Receptor
  Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer.Combined type 2 cytokine blockade enhances PD-1-mediated antitumor immunity.

Representative papers

1. Carnosic acid and carnosol promote lipid mediator class-switching toward inflammation resolution in human macrophages. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2. Dupilumab Alleviates Pulmonary Fibrosis by Interrupting Profibrotic Macrophage-Fibroblast Crosstalk and IL4R/JAK/STAT Signaling. Lung
3. Messenger RNA delivery of a dual CD25/CD122 affinity-tuned IL-2 variant prolongs exposure and potentiates antitumor T cell immunity. Science advances
4. Zhimu-Huangbo herb pair ameliorates diabetic cognitive impairment by modulating the CCL3-CCR5 axis-dependent interaction between neurons and CD8+ T cells. Phytomedicine : international journal of phytotherapy and phytopharmacology
5. AMnESTI reverses age-associated lung immune decline to drive heterosubtypic protection by inactivated influenza vaccines. Science immunology
6. The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases. Virulence
7. Treatment of multiple sclerosis with peptide-coupled red blood cells induces antigen-specific T regulatory cells. Proceedings of the National Academy of Sciences of the United States of America
8. Colitis Ameliorates Murine Autoimmune Cholangitis Through Polarization of M2 Macrophages and Inhibition of CD8+ T-Cells. In vivo (Athens, Greece)

Study types

Randomized trial / meta-analysis 2 · Clinical trial 3 · Human study 54 · Animal (in vivo) 1

Key concepts (papers in this area)

Rituximab 11 · Lupus Erythematosus, Systemic 10 · Glucocorticoids 9 · Lupus Nephritis 8 · Lymphoma, Large B-Cell, Diffuse 6 · Lymphoma, Follicular 6

Sub-areas (papers sharing 3+ concepts)

• 11 Lupus Nephritis · Lupus Erythematosus, Systemic · Immunosuppressive Agents
  Clinical and immunological outcomes of rituximab-based, mycophenolate mofetil-based and cyclophosphamide-based treatment strategies for systemic lupus erythematosus with active kidney involvement from LOOPS registry.Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan.
• 10 Lymphoma, Large B-Cell, Diffuse · Lymphoma, Follicular · Progression-Free Survival
  Epcoritamab with rituximab and lenalidomide as first-line treatment for follicular lymphoma (EPCORE NHL-2): an open-label, multicentre, phase 1/2 b trial.Patterns of care, outcomes, and prognostics for transformed follicular lymphoma in the rituximab era.
• 7 Proteinuria · Glomerulonephritis, IGA · Biopsy
  Clinical Predictors of Non-Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic-Range Proteinuria.Patient characteristics, treatment patterns and clinical outcomes of immunoglobulin a nephropathy (IgAN) in China: a retrospective cohort study.
• 5 Antirheumatic Agents · Janus Kinase Inhibitors · Arthritis, Rheumatoid
  Temporal evolution of synovial histopathology in rheumatoid arthritis across treatment periods: a large-scale analysis of 1770 surgical specimens using the Rooney score.Factors associated with the effectiveness and safety of Janus kinase inhibitors in rheumatoid arthritis: an 8-year observational study from the JAGUAR Registry.

Representative papers

1. Clinical and immunological outcomes of rituximab-based, mycophenolate mofetil-based and cyclophosphamide-based treatment strategies for systemic lupus erythematosus with active kidney involvement from LOOPS registry. RMD open
2. Clinical Predictors of Non-Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic-Range Proteinuria. Nephrology (Carlton, Vic.)
3. Patterns of care, outcomes, and prognostics for transformed follicular lymphoma in the rituximab era. Haematologica
4. Evaluating a guideline-aligned prednisone threshold within the Lupus Low Disease Activity State (LLDAS): associations with damage accrual. RMD open
5. Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan. Lupus science & medicine
6. CD19 CAR T-cell therapy (GLPG5101) for relapsed or refractory B-cell non-Hodgkin lymphoma (ATALANTA-1): phase 1 results from a single-arm, multicentre, phase 1/2 study. The Lancet. Haematology
7. Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease. Annals of medicine
8. Discomfort Avoidance and Desire for Normality Are Decision-Making Drivers of Footwear Choice in Underserved Communities at Risk of Diabetic Foot Ulcer. Journal of foot and ankle research

Study types

Animal (in vivo) 43 · In vitro / preclinical 10

Key concepts (papers in this area)

Mesenchymal Stem Cells 24 · Exosomes 18 · Osteogenesis 13 · Cell Differentiation 11 · Bone Regeneration 6 · Glycolysis 3

Sub-areas (papers sharing 3+ concepts)

• 11 Calcium · Stem Cells · Biocompatible Materials
  Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications.One-step calcium crosslinking of chitosan/alginate/pectin/bioactive glass scaffolds with synergistic osteogenic-angiogenic activity for bone regeneration.
• 6 Bone Marrow-Derived Mesenchymal Stem Cells · BMSCs · Osteogenesis
  3D-printed PCL/nHA/SA/COL loaded with M2 macrophage-derived exosomes alleviates the senescence of bone marrow mesenchymal stem cells.USP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.
• 6 Tendon Injuries · Adipose Tissue · Achilles Tendon
  Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model.Remodeling-phase wound-derived protein factors enhance mesenchymal stem cell function and improve diabetic wound healing.
• 6 Fibrosis · Fibroblasts · Signal Transduction
  Keratinocyte-derived exosomes serve as an active messenger platform for LINC01605 to amplify TGF-β1-induced fibroblasts activation.A novel tsRNA, 5'tiRNA-GluCTC, mediates cardiomyocyte-fibroblast cross-talk to promote cardiac fibrosis in restrictive cardiomyopathy.

Representative papers

1. Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications. Journal of dentistry
2. Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study. BMC oral health
3. Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
4. Mesenchymal Stem Cell-Derived Exosomes Combined With 3-Dimensional Hyaluronan-Based Scaffold Promote Tendon-to-Bone Tunnel Healing. The Journal of hand surgery
5. Chitosan nanoparticles promote TGF-Β1 release from dentin and support stem cell attachment and differentiation in vitro. Journal of dentistry
6. Leek-Derived Exosome-like Nanoparticles Inhibit Hair Growth by Controlling the Differentiation Fate of Hair Follicle Stem Cells. ACS applied bio materials
7. Endothelialized callus organoids drive rapid regeneration of critical-size segmental long bone defects. Cell stem cell
8. Gelatin Methacrylate as a Mesenchymal Stem Cell Delivery Vehicle: Experimental and Semi-Quantitative Evaluation Under Metabolic Stress. Macromolecular bioscience