This month in biomedical research, distilled from PubMed. Updated 2026.09.26.

Study types

Randomized trial / meta-analysis 46 · Clinical trial 24 · Human study 269 · In vitro / preclinical 1

Key concepts (papers in this area)

Antineoplastic Combined Chemotherapy Protocols 49 · Double-Blind Method 28 · Severity of Illness Index 27 · Hematopoietic Stem Cell Transplantation 26 · Cytokine Release Syndrome 11 · Venetoclax 9

Sub-areas (papers sharing 3+ concepts)

• 38 Antineoplastic Combined Chemotherapy Protocols · Progression-Free Survival · Overall Survival
  Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial.Patterns of Response to Durvalumab Plus Tremelimumab and Atezolizumab Plus Bevacizumab in Patients With Unresectable Hepatocellular Carcinoma.
• 20 Receptors, Chimeric Antigen · Immunotherapy, Adoptive · Antigens, CD19
  Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients.Safety and efficacy of allogeneic CD19-directed CAR-T therapy CTX110 in relapsed/refractory B-cell non-Hodgkin lymphoma.
• 15 Venetoclax · Bridged Bicyclo Compounds, Heterocyclic · Sulfonamides
  First-line ibrutinib plus venetoclax for nonblastoid mantle cell lymphoma in patients ≥65 years old or with TP53 mutations.Long-term outcomes of azacitidine, venetoclax, and gilteritinib in newly diagnosed FLT3-mutated AML.
• 15 Janus Kinase Inhibitors · Upadacitinib · Severity of Illness Index
  Efficacy and safety of duvakitug in patients with ulcerative colitis (RELIEVE UCCD): a phase 2b, randomised, placebo-controlled trial.Efficacy and Safety Assessment of Upadacitinib for SAPHO Syndrome: A Retrospective Study of 35 Patients.
• 8 SARS-CoV-2 · COVID-19 Vaccines · COVID-19
  Peak Nasal SARS-CoV-2 and Influenza Viral Loads Relative to Symptom Onset, 2022-2025: Impact of Vaccination and Implications for Multiplexed Testing.Interpreting vaccine-associated survival differences in immune checkpoint inhibitor therapy.
• 8 Lupus Nephritis · Lupus Erythematosus, Systemic · Mortality
  Long-term outcomes and treatments for proliferative lupus nephritis with low-level proteinuria: a multicentre retrospective study in Japan.Efficacy and safety of telitacicept combined with standard of care in patients with proliferative lupus nephritis: a real-world retrospective study.

Elsewhere on this page

• Trial readout Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia.
• Trial readout Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival and event-free survival by pathological response in a global, randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
• Trial readout Oveporexton for Narcolepsy Type 1 - Results from Two Phase 3 Trials.

Representative papers

1. Outcomes of locally produced donor-derived anti-CD19 chimeric antigen receptor T-cells in relapsed or refractory B-cell acute lymphoblastic leukemia patients. Cancer chemotherapy and pharmacology
2. The long-term follow-up outcomes and transition rates across seven representative pediatric congenital surgical conditions: disease severity drives follow-up retention. Pediatric surgery international
3. CT-guided Preoperative Localization of Impalpable Pulmonary Nodules: Comparison Between Two Devices. In vivo (Athens, Greece)
4. Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia. The New England journal of medicine
5. A phase 2 pharmacokinetic and pharmacodynamic dose-finding study of oral NEPA for chemotherapy-induced nausea and vomiting in pediatric patients with cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
6. Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients-A Single-Institution Retrospective Review. Pediatric blood & cancer
7. Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia. Blood
8. Hematopoietic Recovery and Safety Following Early Romiplostim Administration After Pediatric HSCT: A Prospective Randomized Pilot Study. Pediatric blood & cancer

Study types

Human study 20 · Animal (in vivo) 173 · In vitro / preclinical 73

Key concepts (papers in this area)

Anti-Bacterial Agents 81 · Hydrogels 78 · Nanoparticles 75 · Drug Delivery Systems 52 · Wound Healing 49 · Reactive Oxygen Species 44

Sub-areas (papers sharing 3+ concepts)

• 80 Drug Carriers · Drug Delivery Systems · Drug Liberation
  pH-Responsive Chitosan-Coated Spanlastic Nanovesicles for Enhanced Lung-Targeted Delivery of Brilliant Blue G in Acute Lung Injury.Formulation, Optimization and Characterization of Acetazolamide-Loaded Solid Lipid Nanoparticles for Glaucoma Treatment: In-Vitro and In-Vivo Study.
• 56 Microbial Sensitivity Tests · Anti-Bacterial Agents · Structure-Activity Relationship
  Alginate-coated ZIF-8 and PCN-222 metal-organic frameworks for controlled delivery of a benzanthrone derivative: Structure-function relationships, release kinetics, and antibacterial mechanisms.Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy.
• 45 Biocompatible Materials · Neovascularization, Physiologic · Angiogenesis
  Photothermal-responsive dexmedetomidine-loaded MPDA-GelMA hydrogel promotes bone regeneration.Metal Ion-Triggered Collapsed Hydrogels as Materials for Bacterial Population Control.
• 44 Wound Healing · Staphylococcus aureus · Anti-Bacterial Agents
  A novel borneol-loaded PLGA/Chitosan nanoparticles: Synthesis, characterization and evaluation of antioxidant, antibacterial, wound healing and cytotoxic activity on A549 cells.Plasma-activated thermosensitive Pluronic F-127 hydrogel as an antimicrobial dressing for infected wound healing.
• 20 Oxidative Stress · Antifungal Agents · Antioxidants
  An injectable thiolated alginate/oxidized dextran hydrogel with curcumin-copper nanoparticles for corneal neovascularization after alkali burn.Reactive oxygen species-scavenging hydrogels loaded with tempol exert anti-oxidative effects in spinal cord injury rat models.

Elsewhere on this page

• Key finding Intranasal SLNs reduce glioblastoma tumor volume

Representative papers

1. A multi-functional microneedle patch loaded with mupirocin and L-arginine nanoparticles for enhancing antibacterial activity, anti-inflammation and diabetic wound healing. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
2. Alginate-coated ZIF-8 and PCN-222 metal-organic frameworks for controlled delivery of a benzanthrone derivative: Structure-function relationships, release kinetics, and antibacterial mechanisms. International journal of biological macromolecules
3. Gelatin-Based Coating for the Controlled and Localized Delivery of Tetrabranched Antimicrobial Peptide in Cardiac Implantable Devices. ACS applied bio materials
4. Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing. Drug delivery
5. Manganese Dioxide Nanozyme-Constituted Composite Hydrogel to Scavenge Reactive Oxygen Species for Scarless Wound Healing. ACS applied materials & interfaces
6. Efficient Antimicrobial Nanoenzymatic Functionalized Hydrogels for Diabetic Infected Wound Treatment. ACS biomaterials science & engineering
7. An injectable thiolated alginate/oxidized dextran hydrogel with curcumin-copper nanoparticles for corneal neovascularization after alkali burn. Carbohydrate polymers
8. Non-cytotoxic cellulose acetate butyrate composite membrane incorporating a WS2/ZnAl-LDH hybrid for controlled curcumin delivery toward wound dressing applications. International journal of biological macromolecules

Study types

Human study 18 · Animal (in vivo) 151 · In vitro / preclinical 88

Key concepts (papers in this area)

Antineoplastic Agents 156 · Structure-Activity Relationship 138 · Cell Proliferation 133 · Molecular Structure 123 · Dose-Response Relationship, Drug 118 · Apoptosis 94

Sub-areas (papers sharing 3+ concepts)

• 126 Apoptosis · Drug Resistance, Neoplasm · Antineoplastic Agents
  Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies.Development of dual A2AR/EGFR targeting pyrazoline-thiazole hybrids for restored apoptotic balance in colorectal cancer.
• 72 Drug Screening Assays, Antitumor · Cell Proliferation · Molecular Structure
  The design and synthesis of highly efficient FAK inhibitor for the potential treatment of colorectal cancer harboring KRAS mutation.Design, synthesis, and mechanistic study of novel isoflavone derivatives as mitochondrial complex I inhibitors for non-small cell lung cancer treatment.
• 54 Structure-Activity Relationship · Molecular Dynamics Simulation · Molecular Structure
  New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation.Discovery of new thiazolyl hydrazone derivatives as anti-breast cancer agents: Synthesis, biological evaluation and in silico studies.

Representative papers

1. Rationally designed quinazolinone derivatives incorporating acetyl pyridine and thiazole scaffolds as dual EGFR/HER-2 anticancer agents: integrated biological evaluation, molecular profiling, and advanced computational studies. Bioorganic chemistry
2. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic chemistry
3. Discovery of novel imidazo[2,1-b]thiazole-hydrazone hybrids as multi-target anticancer agents: Dual PARP-1/COX-2 inhibition and MetAP-2 modulation. Bioorganic chemistry
4. Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazine derivatives as potent SYK inhibitors for solid tumor therapy. Bioorganic chemistry
5. A novel c-Met inhibitor containing chiral pyrrolidine side chain and its application as anti-tumor agents. European journal of medicinal chemistry
6. Design, synthesis, and biological evaluation of quinolin-2-one/thiazole hybrids as multi-targeted antiproliferative agents inducing caspase-dependent apoptosis. Scientific reports
7. Antineoplastic multi-targeted spiro[indoline-3,2'-pyrrolidines] incorporating urea function: Rational design, synthesis and bio-properties studies. Bioorganic chemistry
8. Design, synthesis and biological evaluation of selective inhibitors against the L858R/T790 M/C797S mutant EGFR kinase based on the scaffold of brigatinib. European journal of medicinal chemistry

Study types

Randomized trial / meta-analysis 18 · Clinical trial 17 · Human study 206 · Animal (in vivo) 1 · In vitro / preclinical 1

Key concepts (papers in this area)

Overall Survival 78 · Biomarkers, Tumor 52 · Progression-Free Survival 44 · Neoadjuvant Therapy 29 · Disease-Free Survival 27 · Magnetic Resonance Imaging 25

Sub-areas (papers sharing 3+ concepts)

• 49 Antibodies, Monoclonal, Humanized · Progression-Free Survival · Lung Neoplasms
  Validation of the lung immune prognostic index in extensive-stage small cell lung cancer: Post hoc analysis of the caspian and IMpower133 phase 3 trials.The addition of bevacizumab to combination chemotherapy in patients with recurrent, persistent, or metastatic cervical cancer: Aretrospective single-arm study.
• 33 Pancreatic Neoplasms · Deep Learning · Carcinoma, Pancreatic Ductal
  Adjuvant oxaliplatin with S-1 (SOX) versus S-1 for stage II-III gastric cancer (CAPITAL): A randomized, open-label, phase 3 trial.Neoadjuvant Gemcitabine Plus S-1 for Resectable Pancreatic Ductal Adenocarcinoma: A Propensity Score-matched Study.
• 27 Breast Neoplasms · Erb-b2 Receptor Tyrosine Kinases · Receptors, Estrogen
  E7389-LF as a first-line chemotherapy for patients with metastatic/advanced HER2-negative breast cancer: results from the phase 1 dose-expansion part of study 114.Chemotherapy type and survival in young BRCA1/2 carriers with HER2-negative early breast cancer.
• 24 Colorectal Neoplasms · Neoplasm Recurrence, Local · Biomarkers, Tumor
  High Cancer Inflammation Prognostic Index Identifies Patients With Stage II Colorectal Cancer With Outcomes Comparable to Stage III.Recurrence detection in patients with triple-negative breast cancer following the current standard of care: a microsimulation model.
• 22 Lymphatic Metastasis · Lymph Nodes · Neoadjuvant Therapy
  Equivalent survival in targeted axillary dissection compared to axillary lymph node dissection in patients with node positive breast cancer receiving neoadjuvant chemotherapy.omitting neck dissection in cT3-4N0M0 oral squamous cell carcinoma with Imaging-Negative nodes after neoadjuvant chemoimmunotherapy: A retrospective cohort study.
• 19 Neutrophils · Neutrophil-to-Lymphocyte Ratio · Inflammation
  Prognostic Value of the Lung Immune Prognostic Index in Metastatic Renal Cell Carcinoma Treated With Second-Line Immunotherapy.Pan-cancer Evaluation of the Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker Across Six Major Solid Tumors.

Elsewhere on this page

• Trial readout Induction and concurrent aumolertinib with radiotherapy for EGFR-mutated stage III NSCLC: results of phase III ADVANCE trial and real-world validation.

Representative papers

1. Combined Pathological Response and PEPI Score Improves Long-term Prognostic Stratification in HR-positive Breast Cancer Following Neoadjuvant Endocrine Therapy. In vivo (Athens, Greece)
2. Metastatic phenotype and post-metastatic survival across HER2-0, HER2-low, and HER2-positive breast cancer. Breast cancer research and treatment
3. Ovarian reserve as a measure of adjuvant chemotherapy benefit in hormone receptor positive (HR-positive), HER2-negative, node-positive breast cancer in SWOG S1007 (RxPONDER). Annals of oncology : official journal of the European Society for Medical Oncology
4. Crossing the milestone: landmark-based conditional survival after first-line CDK4/6 inhibitor therapy in HR+/HER2-metastatic breast cancer. Breast cancer (Tokyo, Japan)
5. Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer - results from the phase II DETECT IVb trial. Breast cancer research and treatment
6. Feasibility of Lower Neck Sparing in Postoperative Radiotherapy for Parotid Gland Cancer. In vivo (Athens, Greece)
7. Mismatch repair deficiency or microsatellite instability in locally advanced rectal cancer patients treated with total neoadjuvant therapy. European journal of cancer (Oxford, England : 1990)
8. Contemporary therapy for small node-negative triple-negative breast cancer: a retrospective cohort study. Breast cancer research and treatment

Study types

Human study 7 · Animal (in vivo) 218 · In vitro / preclinical 12

Key concepts (papers in this area)

Signal Transduction 98 · Inflammation 45 · Oxidative Stress 44 · NF-kappa B 38 · Macrophages 34 · Neuroinflammatory Diseases 28

Sub-areas (papers sharing 3+ concepts)

• 55 Inflammation · Cytokines · Oxidative Stress
  Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes.Ellagic acid regulates astrocytic responses under inflammatory conditions in primary astrocyte cultures: effects on oxidative stress, inflammatory cytokines, and glycogen synthase kinase-3β.
• 39 Neuroinflammatory Diseases · Ferroptosis · Neuroprotective Agents
  Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation.Procyanidin B2 ameliorates hypoxic-ischemic brain damage in neonatal rats by inhibiting pyroptosis via the TLR4/NF-κB signaling pathway.
• 37 Network Pharmacology · Molecular Docking Simulation · Anti-Inflammatory Agents
  Integrated GNPS Molecular Networking and Network Pharmacology Uncover Methylophiopogonanone B as a Novel Anti-Inflammatory Agent From Polygonatum cyrtonema Hua Targeting the SRC-PI3K-Akt Pathway.Zhiwang decoction inhibits the inflammatory response and macrophage polarization in rheumatoid arthritis by mediating the PI3K/AKT phosphorylation pathway through cellular communication network factor 1.
• 23 Proto-Oncogene Proteins c-akt · Phosphatidylinositol 3-Kinases · Signal Transduction
  Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis.Proteomic regulation of anti-proliferative and anti-migratory activity by potent phytochemicals from Pistacia integerrima J.L. Steward Ex Brandis via PI3K, AKT1, and KRAS for Lung Cancer.
• 18 Kidney · RANK Ligand · STAT3 Transcription Factor
  β-carotene attenuates calcium oxalate crystal-induced renal injury through suppression of NF-κB-mediated inflammation.Extracellular vesicle-encapsulated miRNAs mediate monocyte-endothelial cell crosstalk to exacerbate renal injury in diabetic kidney disease.
• 14 Structure-Activity Relationship · Dose-Response Relationship, Drug · Molecular Structure
  Design, synthesis, and evaluation of febuxostat derivatives bearing 1,2,3-triazole: potent inhibitors of microglia-mediated neuroinflammation and oxidative stress via Nrf2-HO-1 activation.Bioassay-guided discovery of anti-inflammatory sesquiterpenoids from Lindera aggregata (Sims) Kosterm.

Elsewhere on this page

• Key finding B4-39 matches crisaborole efficacy

Representative papers

1. Shi-Wei-Long-Dan-Hua capsule alleviates LPS-induced acute lung injury by suppressing pulmonary inflammation and the PI3K-Akt-NF-κB/MAPK axis. Fitoterapia
2. In vivo and molecular docking studies of Micromeria imbricata var. imbricata extract reveal alleviation of the DSS-induced IBD phenotype via interaction with key inflammatory mediators. Journal of ethnopharmacology
3. Integrated GNPS Molecular Networking and Network Pharmacology Uncover Methylophiopogonanone B as a Novel Anti-Inflammatory Agent From Polygonatum cyrtonema Hua Targeting the SRC-PI3K-Akt Pathway. Biomedical chromatography : BMC
4. SLC5A2-SRC-ERK/STAT3 signaling network in proximal tubule S1 cells mediates the renoprotective effects of dapagliflozin in obese mice. Biochemical and biophysical research communications
5. Huanglian Jiedu decoction ameliorates hypertensive nephropathy by inhibiting the AGEs-RAGE/MAPK/AP-1 axis: An integrated transcriptomics and network pharmacology study. Journal of ethnopharmacology
6. Neuroprotective Effect of Isorhapontigenin (ISO) Against LPS-Induced Neurodegenerative Condition via TLR4/RAGE-Mediated p-NF-kB Activation. Molecular neurobiology
7. Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes. Endocrinology, diabetes & metabolism
8. A defined three-compound combination from Artemisia halodendron inhibits PLA2 and 5-LOX and attenuates inflammatory pathology. Fitoterapia

Study types

Randomized trial / meta-analysis 1 · Human study 180 · Animal (in vivo) 2 · In vitro / preclinical 4

Key concepts (papers in this area)

Machine Learning 64 · Biomarkers 56 · Predictive Learning Models 49 · Risk Assessment 45 · Cardiovascular Diseases 26 · Mortality 19

Sub-areas (papers sharing 3+ concepts)

• 62 Biomarkers · Cardiovascular Diseases · Predictive Value of Tests
  Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery.Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study.
• 41 Predictive Learning Models · Machine Learning · Prediction Algorithms
  Machine learning for prediction of large-for-gestational-age neonate with adverse outcome at routine ultrasound examination at 35-37 weeks.Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh.
• 28 Risk Assessment · Machine Learning · Predictive Learning Models
  Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study.Cross-cohort Generalization for Heart Disease Prediction with Explainable AI.
• 11 Neurofilament Proteins · Alzheimer Disease · tau Proteins
  A multimodal model for clinically defined MCI integrating plasma biomarkers and brain microstructural features: a dual-cohort external validation study.The link between plasma and cognitive markers for Alzheimer's disease in Down syndrome: a longitudinal study.

Representative papers

1. Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate. Cardiovascular diabetology
2. Machine learning for prediction of large-for-gestational-age neonate with adverse outcome at routine ultrasound examination at 35-37 weeks. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
3. Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0-3: a nationwide prospective cohort study. Cardiovascular diabetology
4. Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh. PloS one
5. Comparison of High-Sensitivity Troponin T Versus N-Terminal Pro-B-Type Natriuretic Peptide for Prediction of Major Adverse Cardiovascular Events After Noncardiac Surgery. Journal of the American Heart Association
6. Cross-cohort Generalization for Heart Disease Prediction with Explainable AI. Journal of cardiovascular translational research
7. Development and Validation of a Machine Learning-Based Model for Predicting All-Cause Mortality Risk in Patients With Type 2 Diabetes Mellitus Combined With Hypertension: National Cohort Study. JMIR medical informatics
8. The Predictive Value of The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score for One-Month Prognosis and First-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation. Brazilian journal of cardiovascular surgery

Study types

Randomized trial / meta-analysis 11 · Clinical trial 1 · Human study 172

Key concepts (papers in this area)

Neoplasms 48 · HIV Infections 29 · Anxiety 17 · Depression 16 · Caregivers 14 · Cancer Survivors 11

Sub-areas (papers sharing 3+ concepts)

• 21 Anti-HIV Agents · HIV Infections · Antiretroviral Therapy
  Incidence of comorbidities, healthcare resource utilization and costs among people with HIV.Participant perspectives on a person-centred care model for mobile individuals in HIV care from the SEARCH Dynamic Choice Treatment trial in rural Kenya and Uganda.
• 21 Anxiety · Depression · Quality of Life
  Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer.Wearable-derived postdischarge mobility as a digital biomarker for 90-day readmission and mortality in metastatic cancer.
• 18 Neoplasms · Oncology · Interviews as Topic
  Spiritual wellbeing in advanced cancer patients receiving palliative care in a tertiary cancer centre in northern Kerala, India: a qualitative study.Evaluating an innovative support programme for older long-term cancer survivors (IMPULS-A): protocol for a randomised controlled trial.
• 15 Coping Skills · Longitudinal Studies · Adaptation, Psychological
  From diagnosis to daily realities: longitudinal phenomenological exploration of symptom trajectories in glioma survivorship.Multimodal Japanese-style acupuncture and moxibustion for taxane-related chemotherapy-induced peripheral neuropathy in breast cancer survivors.
• 12 COVID-19 Vaccines · Vaccination · COVID-19
  Incorporating public values into public health communications: Effects of value affirmations on intentions to vaccinate and trust in the U.S.Association between post-vaccination adverse events and subsequent COVID-19 booster uptake in the Netherlands.

Representative papers

1. What went wrong? A qualitative exploration of the determinants of poor adherence to antiretroviral therapy and retention in care among pregnant and postpartum women in the Uganda WiseMama trial. Global public health
2. Psychological impact of hospital admission in cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
3. A head-to-head comparison of health utilities and measurement properties of the EQ-5D-5L and SF-6Dv2 among people living with HIV in China. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
4. Exploring the understanding and management of anxiety from cancer in Latino/a older adults and their caregivers. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
5. Addressing Existential Distress Through Compassion: Feasibility and Preliminary Effects of Compassion With You (COMwithU), a Compassion-Based Intervention for Patients With Cancer. Psycho-oncology
6. What makes support groups effective and sustainable? an exploratory qualitative study of people living with HIV in the ICON-3 practice-based research network, Nigeria. BMJ open
7. Beyond Caregiving: Recovery and Growth Among Primary Caregivers Following the Loss of a Family Member Living With Dementia. International journal of geriatric psychiatry
8. Nutritional knowledge, attitudes, and practices (KAP) and GLIM-defined malnutrition in hospitalized head and neck cancer patients receiving surgical treatment: A cross-sectional study in china. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Study types

Randomized trial / meta-analysis 19 · Clinical trial 1 · Human study 117 · In vitro / preclinical 2

Key concepts (papers in this area)

Diabetes Mellitus, Type 2 69 · Blood Glucose 41 · Hypoglycemic Agents 41 · Diabetes Mellitus, Type 1 32 · Glycated Hemoglobin 31 · Insulin 29

Sub-areas (papers sharing 3+ concepts)

• 30 Diabetes Mellitus, Type 2 · Blood Glucose · Glycated Hemoglobin
  Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT.Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality.
• 24 Insulin Infusion Systems · Diabetes Mellitus, Type 1 · Insulin
  Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1).Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study.
• 23 Glucagon-Like Peptide-1 Receptor Agonists · Dipeptidyl-Peptidase IV Inhibitors · Hypoglycemic Agents
  Guideline on treatment intensification with injectable therapies beyond GLP-1 RA based therapies in type 2 diabetes.On target? Cardiovascular risk factor patterns in type 1 and type 2 diabetes: real-world attainment of cardiovascular risk factor targets and medication prescriptions.
• 21 Artificial Intelligence · Self Care · Patient Education as Topic
  The Digital Diabetes Patient Reminder Tool for Adults With Type 2 Diabetes: Protocol for a Proof-of-Concept Randomized Controlled Trial.User Engagement and Feature Preferences in an AI-Powered mHealth Intervention for Diabetes Prevention: Secondary Analysis of a Randomized Controlled Trial.
• 7 Insulin Resistance · UK Biobank · Sex Factors
  Adipose tissue insulin resistance, not muscle insulin resistance, is associated with impaired metabolic health in humans.Elevated plasma glucagon-like Peptide-1 levels are associated with enteral feeding intolerance in traumatic brain injury.

Elsewhere on this page

• Trial readout Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial.

Representative papers

1. Technology choice, glycemic control and patient-reported outcome measures in adults with type 1 diabetes: A randomized crossover trial comparing a smart insulin pen with an automated insulin delivery system (EBIACE-1). Diabetes research and clinical practice
2. Improved glycemic control with the MiniMed 780G system in latent autoimmune diabetes and type 1 diabetes: a real-world observational study. Diabetes research and clinical practice
3. U-500 regular insulin in automated insulin delivery systems for severe insulin resistance: A single-center retrospective cohort. Diabetes research and clinical practice
4. Intensive glycemic control in adults aged 80 years and older: A randomized trial evaluating diabetes complications and competing mortality. Diabetes research and clinical practice
5. Effect of a pharmacist-led mHealth app on adherence, quality of life, and glycaemic control in diabetes: A multicentre RCT. Diabetes research and clinical practice
6. Simplifying meal bolusing with Omnipod 5: real-world outcomes to support simplified user-initiated insulin dosing strategies in managing type 1 or type 2 diabetes. Diabetes research and clinical practice
7. Prescribing Trajectories in Type 2 Diabetes in the United States, 2019-2024. Diabetes, obesity & metabolism
8. The Digital Diabetes Patient Reminder Tool for Adults With Type 2 Diabetes: Protocol for a Proof-of-Concept Randomized Controlled Trial. JMIR research protocols

Study types

Clinical trial 1 · Human study 11 · Animal (in vivo) 94 · In vitro / preclinical 8

Key concepts (papers in this area)

Tumor Microenvironment 48 · Immunotherapy 45 · T-Lymphocytes 22 · Immune Checkpoint Inhibitors 18 · PD-L1 17 · Colorectal Neoplasms 13

Sub-areas (papers sharing 3+ concepts)

• 24 Immune Checkpoint Inhibitors · Programmed Cell Death 1 Receptor · B7-H1 Antigen
  Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer.Differential peripheral immune dynamics underlie therapeutic response to chemotherapy and chemoimmunotherapy in triple-negative breast cancer.
• 18 cGAS-STING Signaling Pathway · STING Protein · Reactive Oxygen Species
  Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation.On-site unlocking and local detonation: A programmed death ligand 1-targeted nanoplatform achieving precise immune activation to convert cold Tumors into hot Tumors.
• 17 Antineoplastic Agents · Triple Negative Breast Neoplasms · Drug Delivery Systems
  \"Alkaline-Hammer Strategy\" Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer.Low-Density Lipoprotein-Mimetic Nanoparticles Codelivering Self-Activated Cabazitaxel Prodrug and Verteporfin for Tumor Chemophotodynamic Therapy and Immune Activation.
• 16 Immunotherapy, Adoptive · Receptors, Chimeric Antigen · CAR T cells
  Targeting Regnase-1 in B7-H3-CAR T cells reprograms the tumor microenvironment and enhances antitumor efficacy for osteosarcoma.CAR T Cells Targeting O-Glycosylated Fibronectin Exhibit Potent Cytolytic Activity and Combine with Tumoral Toll-Like Receptor Agonism to Overcome Tumor Resistance.
• 11 Gene Expression Regulation, Neoplastic · Gene Expression Profiling · Cell Proliferation
  The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (NPC) Differs by Somatostatin Receptor 2 (SSTR2) Expression.Conserved miRNA regulators of PD-1/PD-L1 in glioblastoma and colorectal cancer.
• 11 Immunosuppression Therapy · Antigens, Neoplasm · Cancer Vaccines
  Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.The FAP × CD3 bispecific antibody OMTX305 induces T cell-mediated antitumor effects in patient-derived ex vivo models of solid tumors.

Elsewhere on this page

• Key finding Engineered probiotics induce antitumor immunity

Representative papers

1. Glutathione reductase deficiency potentiates the immunogenicity of ferroptosis and cuproptosis via amplified reactive oxygen species accumulation and cGAS-STING pathway activation. Journal of hematology & oncology
2. Discovery of natural product-derived rosavin as a programmed death-ligand 1 inhibitor for cancer immunotherapy. Phytomedicine : international journal of phytotherapy and phytopharmacology
3. Efficacy and mechanism of topical Chinese herbal formulation JieZe-1 on female lower genital tract co-infection with HSV-2 and Candida albicans via upregulating the cGAS/STING/IFN-I pathway. Journal of ethnopharmacology
4. Enfortumab vedotin induces immunogenic cell death and shows enhanced preclinical antitumor activity when combined with a PD-1 inhibitor. Cell reports. Medicine
5. Low-Density Lipoprotein-Mimetic Nanoparticles Codelivering Self-Activated Cabazitaxel Prodrug and Verteporfin for Tumor Chemophotodynamic Therapy and Immune Activation. Molecular pharmaceutics
6. Targeting the PD-L1-induced PDK4/GLS metabolic axis overcomes anti-PD-1 resistance in non-small cell lung cancer. Journal for immunotherapy of cancer
7. Conserved miRNA regulators of PD-1/PD-L1 in glioblastoma and colorectal cancer. RNA biology
8. Synergistic restoration of NK cell cytotoxicity against solid tumors via sLTA-mediated dual-action modulation. Molecular biology reports

Study types

Randomized trial / meta-analysis 17 · Human study 85 · In vitro / preclinical 1

Key concepts (papers in this area)

Obesity 42 · Body Mass Index 37 · Exercise 18 · Multiple Sclerosis 14 · Weight Loss 13 · Body Composition 12

Sub-areas (papers sharing 3+ concepts)

• 16 Body Composition · Body Mass Index · Muscle, Skeletal
  MFR, SVR and ASVR as promising biomarkers in overweight and obese population with obstructive sleep apnea syndrome: insights from an observational study.Body composition displays expected and unexpected contributions to blood pressure and glycemia in young South African women.
• 11 Lipids · Body Weight · Triglycerides
  A 12-week, double-blind, quasi-randomized, placebo-controlled study to evaluate the efficacy and safety of Coleus forskohlii (Forcslim) on body weight loss.Serum lipidomic profiles associated with Mediterranean diet in overweight and obese breast cancer survivors: an exploratory study.
• 10 Semaglutide · Glucagon-Like Peptides · Glucagon-Like Peptide-1 Receptor Agonists
  Effect of Semaglutide on the Inflammatory Biomarker High-Sensitivity CRP in Patients With Established Cardiovascular Disease and Overweight or Obesity in SELECT: A Prespecified Secondary Analysis.Cancer risk of glucagon-like peptide-1 receptor agonists for obesity: comparison with bariatric surgery and other weight-loss drugs.
• 9 Obesity, Morbid · Fasting · Post-Exercise Recovery
  Time-Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study.A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.
• 9 Cardiometabolic Risk Factors · Cardiovascular Diseases · Uric Acid
  Cardiometabolic profile and cardiorenal complications across BMI categories in type 2 diabetes: A nationwide real-world analysis of over 500,000 patients.Short Sleep Duration Is Positively Associated With Traditional and Non-Traditional Markers of Adiposity and Cardiometabolic Risk in Individuals at Secondary Healthcare: A Cross-Sectional Study.
• 6 Multiple Sclerosis, Chronic Progressive · Magnetic Resonance Imaging · Multiple Sclerosis
  Developing Interim Outcome Measures for Multi-Arm Multistage Clinical Trials in Multiple Sclerosis.Sustained Benefits of a Multidomain Lifestyle Intervention in Multiple Sclerosis in the LIMS Study: A 24-Month Follow-Up.

Elsewhere on this page

• Trial readout A two-center randomized clinical superiority trial of single-anastomosis sleeve ileal bypass versus sleeve gastrectomy for severe obesity: SASSY study protocol.

Representative papers

1. A coherent family support model (Co-Fam) for preventing and treating childhood overweight and obesity: protocol for a randomized hybrid type 2 effectiveness-implementation trial. BMC public health
2. MFR, SVR and ASVR as promising biomarkers in overweight and obese population with obstructive sleep apnea syndrome: insights from an observational study. Annals of medicine
3. Weight Loss-Dependent Changes in Body Composition and Bone Health in People With Obesity and Type 1 Diabetes Treated With Liraglutide, Semaglutide, or Tirzepatide. Diabetes/metabolism research and reviews
4. Remote Monitoring for Rheumatoid Arthritis Flare During Drug Tapering: Protocol for a Prospective Observational Cohort Study. JMIR research protocols
5. Short Sleep Duration Is Positively Associated With Traditional and Non-Traditional Markers of Adiposity and Cardiometabolic Risk in Individuals at Secondary Healthcare: A Cross-Sectional Study. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
6. Appointment adherence, weight reduction, and retention at 9 months in Australian clinical obesity services: a retrospective cohort study. Australian health review : a publication of the Australian Hospital Association
7. Diagnostic accuracy and reliability of equations for the calculation of body fat mass percentage in the Colombian military population: a diagnostic test study. BMJ military health
8. Immediate hemodynamic stabilization with positive airway pressure: PTT-derived nocturnal blood pressure fluctuations during split-night polysomnography. Sleep & breathing = Schlaf & Atmung

Study types

Randomized trial / meta-analysis 8 · Human study 76 · Animal (in vivo) 2 · In vitro / preclinical 1

Key concepts (papers in this area)

Heart Failure 19 · Randomized Controlled Trials as Topic 19 · Renal Insufficiency, Chronic 14 · Sodium-Glucose Transporter 2 Inhibitors 12 · Glomerular Filtration Rate 8 · Myocardial Infarction 7

Sub-areas (papers sharing 3+ concepts)

• 14 Multicenter Studies as Topic · Quality of Life · Randomized Controlled Trials as Topic
  Multicentre, 2×2 factorial, randomised, open-label trial of neuromodulators and cough control therapy for refractory or unexplained chronic cough: the FORTITUDE trial protocol.Randomised comparative effectiveness trial evaluating the efficacy and safety of acupuncture-related integrative therapy combined with celecoxib for chronic pain in patients with knee osteoarthritis: protocol.
• 11 Diabetes Mellitus, Type 2 · Sodium-Glucose Transporter 2 Inhibitors · Glomerular Filtration Rate
  Clinical Evidence of Kidney Protection Exerted by SGLT2 Inhibitors.Serum ketone body levels and risk of incident kidney and cardiovascular events among patients with type 2 diabetes: a prospective cohort study.
• 9 Heart Failure · Myocardial Infarction · Adrenergic beta-Antagonists
  Discontinuation of β-blockers in stable patients with previous myocardial infarction, preserved left ventricular ejection fraction, and no heart failure: a pooled analysis of individual patient data.Heart failure guideline-directed medical therapy in young adults with dystrophin-related cardiomyopathy: the HOPE-MD registry.
• 7 Proteinuria · Biopsy · Kidney
  Clinical Predictors of Non-Diabetic Glomerular Disease in Type 2 Diabetic Patients With Nephrotic-Range Proteinuria.Patient characteristics, treatment patterns and clinical outcomes of immunoglobulin a nephropathy (IgAN) in China: a retrospective cohort study.
• 5 Blood Pressure · Antihypertensive Agents · Diuretics
  Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial.Blood Pressure Variability and Outcomes Across Antihypertensive Regimens.

Representative papers

1. Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial. BMJ open
2. Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety. European journal of clinical pharmacology
3. Influence of Disease-Modifying Therapy on the Efficacy of Vutrisiran in Transthyretin Cardiac Amyloidosis. Journal of the American College of Cardiology
4. Molecular stability overrides size in giant pediatric pheochromocytoma. Journal of pediatric endocrinology & metabolism : JPEM
5. Intelligent pneumoperitoneum system stabilizes hemodynamics in robotic pheochromocytoma resection: a retrospective cohort study. Journal of robotic surgery
6. Effect of levothyroxine therapy on albuminuria and glomerular function in patients with type 2 diabetes and subclinical Hypothyroidism: a randomized controlled pilot trial. Diabetes research and clinical practice
7. Heart failure guideline-directed medical therapy in young adults with dystrophin-related cardiomyopathy: the HOPE-MD registry. European heart journal. Quality of care & clinical outcomes
8. Validating national registry data for randomized trials: comparison of registry-derived cardiovascular events with and without adjudication in the BETAMI-DANBLOCK trial. European heart journal. Quality of care & clinical outcomes

Study types

Randomized trial / meta-analysis 5 · Clinical trial 1 · Human study 57

Key concepts (papers in this area)

Postoperative Complications 23 · Robotic Surgical Procedures 20 · Length of Stay 13 · Laparoscopy 12 · Prostatectomy 11 · Gastrectomy 5

Sub-areas (papers sharing 3+ concepts)

• 14 Prostatic Neoplasms · Prostatectomy · Salvage Therapy
  TAPESTRY study: impact of prior transurethral resection of the prostate on outcomes after robot-assisted radical prostatectomy: a propensity score-matched cohort study.Optimal prostate-specific antigen thresholds for early salvage therapy after robotic-assisted radical prostatectomy.
• 12 Laparoscopy · Colorectal Surgical Procedures · Stomach Neoplasms
  Impact of Non-curative Endoscopic Submucosal Dissection on Minimally Invasive Distal Gastrectomy and on Robotic Versus Laparoscopic Approaches in pT1 Gastric Cancer.Staying minimally invasive: robotic versus laparoscopic colorectal cancer surgery in a propensity-weighted Italian multicentre cohort.
• 8 Lung Neoplasms · Pneumonectomy · Carcinoma, Non-Small-Cell Lung
  Clinical performance of da Vinci 5 versus Xi for robotic anatomic lung resection: a propensity-weighted analysis.Biological surgical stress after minimally invasive lung resection for non-small cell lung cancer: comparing robotic and thoracoscopic surgical platforms.
• 8 Nephrectomy · Kidney Neoplasms · Carcinoma, Renal Cell
  Perioperative safety and survival outcomes of robot-assisted partial nephrectomy in elderly patients with localized renal cell carcinoma: an overlap-weighted Asian cohort study.Impact of resection bed management on postoperative outcomes after Robot-Assisted Partial Nephrectomy : a retrospective French Nationwide Study (UroCCR 215).

Representative papers

1. Perioperative safety and survival outcomes of robot-assisted partial nephrectomy in elderly patients with localized renal cell carcinoma: an overlap-weighted Asian cohort study. Journal of robotic surgery
2. Clinical performance of da Vinci 5 versus Xi for robotic anatomic lung resection: a propensity-weighted analysis. Journal of robotic surgery
3. TAPESTRY study: impact of prior transurethral resection of the prostate on outcomes after robot-assisted radical prostatectomy: a propensity score-matched cohort study. Journal of robotic surgery
4. Side-specific lower detrusor apron-sparing robot-assisted radical prostatectomy: functional and oncological outcomes. World journal of urology
5. Association of preoperative systemic immune-inflammation index and atherogenic index of plasma with early postoperative clinical outcomes in patients undergoing isolated elective coronary artery bypass grafting with cardiopulmonary bypass. Cardiovascular journal of Africa
6. Total periurethral anatomical preservation during single-port extraperitoneal robot-assisted radical prostatectomy using a modified hood technique. Journal of robotic surgery
7. Single-port robotic prostatectomy is associated with higher same-day discharge and reduced length of stay: a NSQIP analysis. World journal of urology
8. Through-the-scope twin clip for closure of gastric endoscopic full-thickness resection defects: a retrospective comparative study. Annals of medicine

Study types

Human study 3 · Animal (in vivo) 38 · In vitro / preclinical 11

Key concepts (papers in this area)

Exosomes 16 · Mesenchymal Stem Cells 15 · Cell Differentiation 10 · Osteogenesis 9 · Extracellular Vesicles 5 · Glycolysis 5

Sub-areas (papers sharing 3+ concepts)

• 7 Cell Movement · Signal Transduction · Gene Expression Regulation, Neoplastic
  Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells.Keratinocyte-derived exosomes serve as an active messenger platform for LINC01605 to amplify TGF-β1-induced fibroblasts activation.
• 7 Tendon Injuries · Regeneration · Muscle, Skeletal
  Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model.Remodeling-phase wound-derived protein factors enhance mesenchymal stem cell function and improve diabetic wound healing.
• 5 Stem Cells · Microscopy, Electron, Scanning · Human Dental Pulp Stem Cells
  Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications.Chitosan nanoparticles promote TGF-Β1 release from dentin and support stem cell attachment and differentiation in vitro.
• 5 BMSCs · Aging · Osteogenesis
  3D-printed PCL/nHA/SA/COL loaded with M2 macrophage-derived exosomes alleviates the senescence of bone marrow mesenchymal stem cells.USP22 alleviates oxidative stress-induced BMSCs senescence by stabilizing SPI1 protein.

Representative papers

1. Porous phosphate glass microspheres loaded with dental pulp stem cell-derived exosomes for potential osteogenic applications. Journal of dentistry
2. Shockwave-Induced Myoblast Exosome-Like Vesicles: Emerging Drivers of Muscle Regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology
3. The PROM1+SMAD5+ Tumor-Initiating Subpopulation Shapes Premetastatic Niches through Spatial Multi-Omics Landscapes in HER2-Positive Breast Cancer. Cancer communications (London, England)
4. Leek-Derived Exosome-like Nanoparticles Inhibit Hair Growth by Controlling the Differentiation Fate of Hair Follicle Stem Cells. ACS applied bio materials
5. HDCA suppresses exosomal lncRNA MSTRG171708 release to inhibit Treg-mediated immunometabolism in hepatocellular carcinoma. Molecular biomedicine
6. ALY688 Protects Against Myocardial Ischemia-Reperfusion Injury via Direct Effects and Rab8a-Dependent Extracellular Vesicles. Journal of extracellular vesicles
7. Macropa-Based 225Ac-Labeled RGD Peptides for Targeted Alpha Therapy. Molecular pharmaceutics
8. Decellularized tendon scaffold seeded with adipose-derived MSCs and supplemented with G-CSF injection promotes tendon repair in a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie