BioLLM Wiki β€Ί Delivery & Formulation

Antimicrobial Agents

Research on antimicrobial strategies in these papers spans antibiotic-resistance surveillance and treatment optimization, development of antimicrobial peptides using machine learning and de novo design, Ξ²-lactamase-inhibitor combinations, cranberry-functionalized hydrogels, and phage-inspired nanocarrier delivery systems. The studies address resistant bacterial infections, diabetic foot ulcers, chronic antibiotic-refractory pouchitis, and wound inflammation, using patient populations, clinical bacterial isolates, microbiological susceptibility assays, machine learning, animal models, and genomic and molecular analyses. Several approaches combine antimicrobial activity with biofilm control, reduced inflammation or oxidative stress, and improved wound healing or tissue recovery.

Papers
5,059
Jan 2024 – Aug 2026
2024 share
4.16%
of the month's papers, on average
2025 share
4.53%
of the month's papers, on average
2026 share
4.14%
of the month's papers, on average
Change
β–Ό -0.5%
2024 β†’ 2026, relative

Share of papers by month

Peak 5.14% in Apr 2025. Month-by-month values and sub-terms are on Keyword Trends.

Jan 2024Aug 2026

Resistance and treatment

Several studies examined antibiotic resistance in relation to infection risk, prognosis, susceptibility, and treatment. SSRI exposure was associated with a higher risk of antibiotic-resistant infection in a target-trial emulation using survival regression and causal survival forest analyses (PMID 40417572), while antibiotic exposure was examined as a prognostic factor in patients with advanced metastatic non-small-cell lung cancer receiving immune checkpoint inhibitors (PMID 39302841). Other studies evaluated sulbactam/durlobactam activity and resistance mechanisms in 1,303 carbapenem-resistant Acinetobacter baumannii isolates, and the effectiveness and safety of oral fosfomycin for multidrug-resistant Enterobacterales urinary tract infections in patients with type 2 diabetes mellitus (PMIDs 41016597, 42323170).

πŸ“„ AMIA ... Annual Symposium proceedings. AMIA Symposium β†—πŸ“„ European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) β†—πŸ“„ Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases β†—πŸ“„ Diabetes research and clinical practice β†—

Computational agent discovery

Computational methods were used to study antimicrobial peptides, DNA minor-groove binders, cyclic heptapeptides, and inhibitors of Klebsiella pneumoniae aspartate Ξ²-semialdehyde dehydrogenase. AP_Sin classified antimicrobial peptides from sequence data, while AP_Gen generated de novo tridecapeptide candidates; separate studies designed DNA minor-groove binders and cyclic heptapeptides as potential antibacterial agents against MRSA, and designed K. pneumoniae aspartate Ξ²-semialdehyde dehydrogenase inhibitors using structure-based drug design, molecular docking, molecular dynamics, virtual screening, and experimental assays (PMIDs 38416364, 38678825, 41359057, 40617981). Subtractive proteomics identified 161 essential, non-homologous proteins unique to Enterococcus faecalis V583, and highlighted alanine racemase as a potential drug target; structure-based virtual screening identified five phytochemicals with strong binding affinities toward the enzyme (PMID 41760878).

πŸ“„ Interdisciplinary sciences, computational life sciences β†—πŸ“„ European journal of medicinal chemistry β†—πŸ“„ Naunyn-Schmiedeberg's archives of pharmacology β†—πŸ“„ Molecular diversity β†—πŸ“„ Molecular biotechnology β†—

Natural and metal-based agents

Plant extracts, isolated phytochemicals, and biologically produced metal nanoparticles are investigated as antibacterial or antiviral agents. Oxypeucedanin and osthol from Prangos aricakensis, cacao pod husk extracts, Pistacia lentiscus stem extracts, and Cucurbita maxima pulp extract were chemically profiled and tested with antibacterial, antioxidant, enzyme-inhibition, or antibiofilm assays (PMIDs 38214506, 38526663, 38801327, 40538189). Green synthesis approaches produced silver nanoparticles from Citrus limon and graphene oxide-silver composites from Cucumis callosus, which showed antiviral or antibacterial activity, respectively (PMIDs 39181453, 39318246).

πŸ“„ Journal of biomolecular structure & dynamics β†—πŸ“„ Applied biochemistry and biotechnology β†—πŸ“„ International journal of environmental health research β†—πŸ“„ Food science and technology international = Ciencia y tecnologia de los alimentos internacional β†—πŸ“„ Virus research β†—πŸ“„ Microscopy research and technique β†—

Responsive wound biomaterials

Several materials respond to infection-associated or external stimuli while providing antimicrobial activity and supporting tissue repair. Examples include a graphene oxide–cranberry hydrogel for near-infrared photothermal antibiofilm treatment and wound healing in diabetic foot ulcers, an AgNC- and TNF-Ξ±-antibody DNA hydrogel for antibacterial treatment and regeneration of diabetic alveolar bone defects, and ultrasound-triggered polylactic-acid pockets for delayed local vancomycin release in the setting of instrumented spine surgery (PMIDs 39651355, 38014713, 41379814). Other systems use pH-responsive silver release or laser-triggered reactive oxygen species to combine antibacterial activity with wound healing (PMIDs 39673457, 40684643).

πŸ“„ International journal of nanomedicine β†—πŸ“„ Macromolecular rapid communications β†—πŸ“„ PloS one β†—πŸ“„ Advanced biology β†—πŸ“„ Biomaterials β†—πŸ“„ Frontiers in cellular and infection microbiology β†—

Peptide and targeted delivery

Peptides and nanocarriers have been investigated to improve antimicrobial selectivity, stability, or activity against biofilms and resistant bacteria. Exosome-loaded LL-37 inhibited Zika virus infection in vitro and in vivo, while phage-receptor-targeted polymeric micelles delivered dual antibiotics in a mouse model of Staphylococcus aureus sepsis. The untargeted nanodrug reduced MIC values two- to tenfold for vancomycin and nine- to 75-fold for oxacillin, and targeted micelles further reduced MIC values in resistant strains (PMIDs 38460762, 39965672). Anionic lipid nanoparticles delivered polymyxin B and used fractionated release to enhance binding to the outer membrane of Gram-negative bacteria, while arginine-based surfactants showed activity against bacteria, fungi, methicillin-resistant strains, and mature biofilms (PMIDs 40451556, 40344742). In periodontitis, berberine-loaded dental-pulp-stem-cell exosomes were used with antimicrobial photodynamic therapy against Porphyromonas gingivalis biofilms (PMID 41802454).

πŸ“„ Antiviral research β†—πŸ“„ Journal of controlled release : official journal of the Controlled Release Society β†—πŸ“„ Journal of controlled release : official journal of the Controlled Release Society β†—πŸ“„ Colloids and surfaces. B, Biointerfaces β†—πŸ“„ Photodiagnosis and photodynamic therapy β†—

Written by gpt-5.6-luna from 96 of this keyword's papers, a few from every whole month through Aug 2026; every paragraph was checked against the abstracts it cites. A paper counts for the keyword when its title, abstract, keywords or MeSH headings match the keyword's terms. Not medical advice; see the Disclaimer.