BioLLM Wiki β€Ί Mechanisms & Targets

Apoptosis

The papers use apoptosis as a mechanistic endpoint in studies of cancer treatment, drug resistance, tissue injury, and metabolic disease. Approaches include drug combinations and targeted inhibitors, nanocarrier systems, transcriptomic or multi-omics analyses, cell-based apoptosis assays, and rodent models.

Papers
6,822
Jan 2024 – Aug 2026
2024 share
5.69%
of the month's papers, on average
2025 share
6.00%
of the month's papers, on average
2026 share
5.62%
of the month's papers, on average
Change
β–Ό -1.2%
2024 β†’ 2026, relative

Share of papers by month

Peak 7.31% in Jan 2025. Month-by-month values and sub-terms are on Keyword Trends.

Jan 2024Aug 2026

Cancer therapy and resistance

Studies examined strategies to overcome drug resistance and induce apoptosis in cancer cells. BFL-1 inhibitor 56 overcame venetoclax resistance and, combined with venetoclax, induced stronger apoptosis in BFL-1-overexpressing AML cell lines, while APG-1252 enhanced paclitaxel’s anticancer effects in NSCLC cells by suppressing the ERK/MCL-1 pathway; in venetoclax-resistant AML cells, venetoclax induced sublethal apoptotic signaling and mitochondrial outer-membrane permeabilization, creating a vulnerability to PARP inhibition, and adding azacitidine enhanced venetoclax-induced DNA damage and sensitivity (PMIDs 38913996, 41608859, 39414773). Other studies found that DUSP1 was overexpressed in osimertinib-resistant NSCLC cells and that its silencing restored osimertinib sensitivity and enhanced apoptosis, that USP8 stabilized EIF2S1 and contributed to TKI resistance in CML, and that RAS/PI3K pathway-mutant epithelial ovarian cancer cells were sensitive to FK866 and to the olaparib–FK866 combination (PMIDs 38551790, 41147744, 41419662).

πŸ“„ Journal of medicinal chemistry β†—πŸ“„ Anti-cancer drugs β†—πŸ“„ Cell death & disease β†—πŸ“„ Molecular biotechnology β†—πŸ“„ The FEBS journal β†—πŸ“„ Communications biology β†—

Nanomedicine and phototherapy

Nanoparticles and multimodal platforms are used to concentrate cytotoxic or photoactive agents and induce apoptosis through oxidative, mitochondrial, or combined photothermal and photodynamic mechanisms. Doxorubicin-sanguinarine nanoparticles were tested in sensitive and doxorubicin-resistant MCF-7 cells, while CsxWO3 nanobubbles combined NIR photothermal and photodynamic therapy with CT and contrast-enhanced ultrasound guidance for hepatocellular carcinoma (PMIDs 38180322, 39679255). Other systems used mitochondria- and lysosome-targeted photosensitizers, engineered bacteria producing H2S together with CuS nanoparticles, or a pH-responsive gallium/manganese nanoplatform to promote tumor-cell apoptosis and immune activation (PMIDs 39967393, 40820708, 41151369).

πŸ“„ Drug development and industrial pharmacy β†—πŸ“„ International journal of nanomedicine β†—πŸ“„ Advanced healthcare materials β†—πŸ“„ Advanced healthcare materials β†—πŸ“„ Biomaterials β†—

Protecting injured tissues

Oleuropein reduced infarct area, histological damage, and white-matter injury in seven-day-old mice after hypoxia-ischemia and reduced caspase-3 overexpression, indicating modulation of apoptosis. Glycyrrhizic acid protected hippocampal neurons by inhibiting apoptosis through the PI3K/AKT pathway in oxygen-glucose deprivation/reoxygenation and middle cerebral artery occlusion models, while also reducing cerebral infarct size in MCAO rats (PMIDs 39157939, 39377899). Suppressing STING expression with shRNA or the inhibitor C176 inhibited apoptosis and senescence in LPS-induced sepsis-associated acute kidney injury models. DRAK2 inhibitors protected against palmitic-acid-induced apoptosis, enhanced mitochondrial membrane potential in INS-1E cells, and increased glucose-stimulated insulin secretion in primary mouse islets (PMIDs 38913144, 41109008).

πŸ“„ Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism β†—πŸ“„ Biochemical genetics β†—πŸ“„ Inflammation β†—πŸ“„ European journal of medicinal chemistry β†—

Apoptosis and regulated cell death

Several papers examined signaling mechanisms involving pyroptosis and PANoptosis. STING depletion in renal cell carcinoma activated the PERK/eIF2Ξ±/ATF4/CHOP pathway and caspase-8 cleavage, inducing GSDMD-mediated pyroptosis, whereas dihydromyricetin inhibited pyroptosis and oxidative stress in spinal cord injury mice and in H2O2-treated microglia through STING-associated autophagy (PMIDs 38548966, 40731204). In AGEs-primed cardiomyocytes subjected to hypoxia/reoxygenation, advanced glycation end-products caused mitochondrial oxidative damage and activated the AIM2-ZBP1 PANoptosome, with increased cleaved caspase-3, GSDMD, and phosphorylated MLKL; in glioblastoma, a quercetin/chlorogenic-acid prodrug delivered by a tumor-derived exosome-liposome nanoplatform was designed to amplify caspase-associated GSDME-mediated pyroptosis (PMIDs 42176503, 42466899).

πŸ“„ Oncogene β†—πŸ“„ Biochemical genetics β†—πŸ“„ Redox biology β†—πŸ“„ ACS nano β†—

Written by gpt-5.6-luna from 96 of this keyword's papers, a few from every whole month through Aug 2026; every paragraph was checked against the abstracts it cites. A paper counts for the keyword when its title, abstract, keywords or MeSH headings match the keyword's terms. Not medical advice; see the Disclaimer.