BioLLM Wiki β€Ί Mechanisms & Targets

Ferroptosis

These papers examine ferroptosis as an iron-dependent, lipid-peroxidation-related cell-death process in cancer, diabetic nephropathy, renal aging, cerebral ischemic injury, and retinal degeneration. Studies use cultured cells and rodent disease models, as well as single-cell RNA sequencing, transcriptomic analyses, and BBB-targeted lipid nanoparticles. They identify regulators and mediators including GPX4, ferritin heavy chain, NRF2, ACSL4, Pcbp1, AATK, and NOX4, and investigate strategies to induce ferroptosis in tumors or suppress it in injured and diseased tissues.

Papers
1,603
Jan 2024 – Aug 2026
2024 share
1.18%
of the month's papers, on average
2025 share
1.33%
of the month's papers, on average
2026 share
1.61%
of the month's papers, on average
Change
β–² +36.4%
2024 β†’ 2026, relative

Share of papers by month

Peak 1.86% in Feb 2026. Month-by-month values and sub-terms are on Keyword Trends.

Jan 2024Aug 2026

Ferroptosis in tissue injury

Ferroptosis is implicated in myocardial, cerebral, retinal, renal, and diabetic nephropathy injury. TPP-MR reduced myocardial injury, oxidative stress, and lipid peroxidation-related changes in hemorrhagic-shock rats and hypoxic H9C2 cardiomyocytes, while blood-brain-barrier-targeted lipid nanoparticles enhanced the penetration and neuroprotective effects of Ferrostatin-1 in experimental cerebral ischemia (PMIDs 39081897, 38857748). In other disease models, restoration of PEDF expression ameliorated sodium-iodate-induced retinal dysfunction and inhibited retinal pigment epithelium ferroptosis, hUCMSCs inhibited ferroptosis in diabetic nephropathy through the JNK/KEAP1/NRF2 signaling pathway, and fullerenol nanoparticles reduced renal lipid peroxidation and ferrous iron accumulation in cisplatin-induced acute kidney injury (PMIDs 38153666, 39602247, 39509775).

πŸ“„ International journal of nanomedicine β†—πŸ“„ Experimental neurology β†—πŸ“„ GeroScience β†—πŸ“„ Antioxidants & redox signaling β†—πŸ“„ Journal of colloid and interface science β†—

Nanomedicine for tumor ferroptosis

A ROS-responsive Fe3O4-based nanoparticle released glucose oxidase and the immune-activating peptide Tuftsin in the tumor microenvironment, enhancing ferroptosis and promoting the recruitment of effector T cells in lung metastases. DMEFe nanoparticles provided pH-sensitive doxorubicin release and induced ferroptosis in OSCC cells. The photosensitizer–bufalin conjugate MB-Buf was designed for light-activated GPX4 photodegradation, generated reactive oxygen species under irradiation, and inhibited tumor growth in a 4T1-Luci xenograft mouse model. In SCLC mouse models, RGD-labeled liposomes carrying cisplatin and surufatinib enhanced ferroptosis and inhibited angiogenesis; combining them with Ξ±CD47 further promoted ferroptosis and antitumor immune responses (PMIDs 38551448, 39450626, 40449152, 41130421).

πŸ“„ Angewandte Chemie (International ed. in English) β†—πŸ“„ Bioconjugate chemistry β†—πŸ“„ Bioorganic chemistry β†—πŸ“„ Journal of controlled release : official journal of the Controlled Release Society β†—

Iron metabolism and ferritinophagy

Several studies connect ferroptosis sensitivity to intracellular iron accumulation and ferritinophagy. Pt-3 induced ferritinophagy-dependent ferroptosis and showed less toxicity and better therapeutic activity than cisplatin in vivo, whereas NCOA4-mediated ferritinophagy contributed to silica-nanoparticle lung injury and zinc-oxide-nanoparticle neurotoxicity. Ferrostatin-1 alleviated silica-nanoparticle-induced ferroptosis and lung injury, while deferoxamine and 3-methyladenine alleviated effects of zinc-oxide nanoparticles. In diabetic cognitive dysfunction, melatonin attenuated ACSL4-dependent ferroptosis and reversed NCOA4-mediated ferritinophagy. In diabetic cardiomyopathy, DNA-PKcs phosphorylated YAP1 at Thr226, promoting its nuclear retention and increasing transcription of ferroptosis-associated genes (PMIDs 38526421, 40544907, 42102950, 41418601, 40279648).

πŸ“„ Journal of medicinal chemistry β†—πŸ“„ Chemico-biological interactions β†—πŸ“„ Chemico-biological interactions β†—πŸ“„ Bioorganic chemistry β†—πŸ“„ Advanced science (Weinheim, Baden-Wurttemberg, Germany) β†—

Ferroptosis and treatment resistance

Downregulation of AATK increased susceptibility to ferroptosis in EGFR-TKI-resistant lung-cancer cells, whereas FAT4 loss in hepatocellular carcinoma promoted resistance to the ferroptosis inducers RSL3 and sorafenib and increased GPX4 and SLC7A11 levels (PMIDs 39871626, 41832339). In colorectal cancer, overexpressed xCT/SLC7A11 and SLC3A2 were investigated using CRISPR-screen data and functional assays in five primary patient-derived organoid models, and a cell-surface protein signature associated with chemotherapy resistance was identified. In osteosarcoma, cancer-associated-fibroblast-derived exosomal miR-22-3p downregulated PTEN and ferroptosis and promoted cisplatin resistance (PMIDs 40988536, 40972800).

πŸ“„ The Journal of pathology β†—πŸ“„ Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico β†—πŸ“„ Molecular oncology β†—πŸ“„ Cellular signalling β†—

Written by gpt-5.6-luna from 96 of this keyword's papers, a few from every whole month through Aug 2026; every paragraph was checked against the abstracts it cites. A paper counts for the keyword when its title, abstract, keywords or MeSH headings match the keyword's terms. Not medical advice; see the Disclaimer.