BioLLM Wiki β€Ί Metabolic & Endocrine

Obesity

The papers examine associations of obesity and metabolic health with cancer, COVID-19 severity and mortality, progression from prediabetes to diabetes among people with HIV, pediatric dyspnea, and idiopathic intracranial hypertension, using cohort analyses, administrative claims data, a federated research database, phase 1 randomized studies, and retrospective medical records. They also evaluate the oral GLP-1 receptor agonist lotiglipron in participants with type 2 diabetes or obesity and bariatric surgery as a treatment for idiopathic intracranial hypertension.

Papers
7,957
Jan 2024 – Aug 2026
2024 share
7.11%
of the month's papers, on average
2025 share
7.29%
of the month's papers, on average
2026 share
5.76%
of the month's papers, on average
Change
β–Ό -19.0%
2024 β†’ 2026, relative

Share of papers by month

Peak 8.12% in Feb 2024. Month-by-month values and sub-terms are on Keyword Trends.

Jan 2024Aug 2026

Obesity and disease risk

Population studies examined associations of obesity measures and metabolic health with cancer and mortality, COVID-19 severity and mortality, progression from prediabetes to diabetes, and outcomes among patients undergoing cardiac resynchronization therapy. In the Kailuan cohort, BMI, waist circumference, and metabolic health were combined into six obesity phenotypes and analyzed with Cox models for cancer risk and all-cause mortality. In Japanese hospitalized patients with COVID-19, critical illness increased monotonically with BMI, while mortality followed a J-shaped association. Among people with HIV aged 40 years or older who had prediabetes, higher BMI and waist circumference were associated with increased risk of progression to diabetes. Among patients undergoing cardiac resynchronization therapy, BMI-defined obesity was examined in relation to all-cause mortality, heart transplantation, left ventricular assist device implantation, periprocedural complications, and echocardiographic response (PMIDs 39479267, 38636933, 38923420, 39031161).

πŸ“„ Frontiers in endocrinology β†—πŸ“„ Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy β†—πŸ“„ AIDS (London, England) β†—πŸ“„ ESC heart failure β†—

Drug-based weight management

These studies evaluated GLP-1–pathway drugs in populations including type 1 diabetes, type 2 diabetes, and obesity. In adults with type 1 diabetes and a mean BMI of 36.7 kg/mΒ², observational tirzepatide treatment was associated with HbA1c reductions of 0.45% at 3 months and 0.59% at 8 months. A phase 1 program evaluated the safety, pharmacokinetics, and pharmacodynamics of oral GLP-1 receptor agonist lotiglipron in participants with type 2 diabetes and/or obesity, with nausea the most frequently reported adverse event. A randomized trial of exenatide in overweight or obese adults treated with olanzapine found mean weight changes of βˆ’0.5 kg with exenatide versus +2.6 kg with placebo over 16 weeks (PMIDs 38317405, 38751362, 40203970).

πŸ“„ Journal of diabetes science and technology β†—πŸ“„ Diabetes, obesity & metabolism β†—πŸ“„ Journal of affective disorders β†—

Bariatric surgery outcomes

Clinical studies evaluated perioperative management, behavioral response, comorbidity outcomes, and long-term procedure performance in people with obesity. A 206-case study tested a systematic preoperative bariatric-surgery protocol for consultation efficiency, hospital stay, surgical duration, and costs; a prospective sleeve-gastrectomy cohort used control-of-eating questionnaires at baseline and 3, 6, and 12 months to compare patients achieving at least 25% total weight loss with those who did not. Other cohorts examined symptom and intracranial-pressure outcomes after bariatric surgery in idiopathic intracranial hypertension and 10-year weight-loss, remission, and complication outcomes after biliopancreatic diversion with duodenal switch or single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (PMIDs 39444955, 38502520, 39365468, 40962919).

πŸ“„ Frontiers in public health β†—πŸ“„ Obesity surgery β†—πŸ“„ Surgical endoscopy β†—πŸ“„ Surgical endoscopy β†—

Adipose and gut mechanisms

Preclinical studies examined a yellow leaf green tea extract, a hyaluronic-acid microneedle delivery system, and signaling mechanisms related to adiposity, inflammation, lipid synthesis, and thermogenesis. Yellow leaf green tea extract reduced body weight, hepatic inflammation, fat accumulation, and hyperlipidemia in high-fat-diet C57BL/6J mice while activating AMPK/CPT-1Ξ± and inhibiting FAS/ACC/SREBP-1c; fecal microbiota transplantation was used to investigate the contribution of altered gut microbiota. A fast-soluble hyaluronic-acid microneedle matrix containing a weak acid-degradable oleanolic acid dimer of rosiglitazone released rosiglitazone in obese mice; oleanolic acid improved the inflammatory status of obese adipose tissue, and the treatment promoted white-adipocyte browning. Hyperforin promoted adipose thermogenesis through a Dlat–Trpv3–AMPK pathway, whereas the MIF tautomerase inhibitor 4-IPP promoted mitochondrial thermogenesis and adipocyte browning through mechanisms involving CD137 and PI3K/AKT signaling (PMIDs 38407390, 38941683, 39631519, 41741765).

πŸ“„ Journal of the science of food and agriculture β†—πŸ“„ Biomaterials β†—πŸ“„ Journal of advanced research β†—πŸ“„ Acta pharmacologica Sinica β†—

Predicting obesity treatment response

Several studies evaluated biological or functional markers related to monogenic obesity diagnosis or weight-loss outcomes. Monogenic-obesity testing in children and adolescents reassessed variants in genes including LEPR, POMC, MC4R, and PCSK1 using updated software interpretation and literature review, improving classification certainty. A pilot sleeve-gastrectomy cohort analyzed gut microbiome and genetic profiles in relation to 12-month excess-weight-loss success and identified an association between the genus Akkermansia and weight loss, while another study evaluated preoperative six-minute-walk-test measures as predictors of early nonresponse after metabolic and bariatric surgery (PMIDs 39462520, 40533342, 41657084).

πŸ“„ Pediatric obesity β†—πŸ“„ Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery β†—πŸ“„ Physiotherapy theory and practice β†—

Written by gpt-5.6-luna from 96 of this keyword's papers, a few from every whole month through Aug 2026; every paragraph was checked against the abstracts it cites. A paper counts for the keyword when its title, abstract, keywords or MeSH headings match the keyword's terms. Not medical advice; see the Disclaimer.